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- W3119480892 endingPage "113149" @default.
- W3119480892 startingPage "113149" @default.
- W3119480892 abstract "Colorectal cancer (CRC) is one of the major causes of carcinogenic mortality in numbers only after lung and breast cancers. The mutations in adenomatous polyposis coli (APC) gene leads to formation of colorectal polyps in the colonic region and which develop as a malignant tumour upon coalition with patient related risk factors. The protein-protein interaction (PPI) of APC with Asef (A Rac specific guanine nucleotide exchange factor) overwhelms the patient’s conditions by rapidly spreading in the entire colorectal region. Most mutations in APC gene occur in mutated cluster region (MCR), where it specifically binds with the cytosolic β-catenin to regulate the Wnt signalling pathway required for CRC cell adhesion, invasion, progression, differentiation and stemness in initial cell cycle phages. The current broad spectrum perspective is attempted to elaborate the sources of identification, development of selective APC inhibitors by targeting emopamil-binding protein (EBP) & dehydrocholesterol reductase-7 & 24 (DHCR-7 & 24); APC-Asef, β-catenin/APC, Wnt/β-catenin, β-catenin/TCF4 PPI inhibitors with other vital Wnt signal cellular proteins and APC/Pol-β interface of colorectal cancer. In this context, this perspective would serve as a platform for design of new medicinal agents by targeting cellular essential components which could accelerate anti-colorectal potential candidates." @default.
- W3119480892 created "2021-01-18" @default.
- W3119480892 creator A5023193536 @default.
- W3119480892 creator A5070305207 @default.
- W3119480892 creator A5071359319 @default.
- W3119480892 creator A5084854319 @default.
- W3119480892 date "2021-02-01" @default.
- W3119480892 modified "2023-10-18" @default.
- W3119480892 title "A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors" @default.
- W3119480892 cites W1489084607 @default.
- W3119480892 cites W1499895161 @default.
- W3119480892 cites W1588334150 @default.
- W3119480892 cites W1591858261 @default.
- W3119480892 cites W1821666761 @default.
- W3119480892 cites W1904120886 @default.
- W3119480892 cites W1951102280 @default.
- W3119480892 cites W1963607807 @default.
- W3119480892 cites W1966109603 @default.
- W3119480892 cites W1967596683 @default.
- W3119480892 cites W1967711052 @default.
- W3119480892 cites W1971458298 @default.
- W3119480892 cites W1972576177 @default.
- W3119480892 cites W1984374880 @default.
- W3119480892 cites W1986197876 @default.
- W3119480892 cites W1988845690 @default.
- W3119480892 cites W1993543264 @default.
- W3119480892 cites W1993921134 @default.
- W3119480892 cites W1994684236 @default.
- W3119480892 cites W1994947876 @default.
- W3119480892 cites W1994951109 @default.
- W3119480892 cites W2001985240 @default.
- W3119480892 cites W2004405471 @default.
- W3119480892 cites W2005364473 @default.
- W3119480892 cites W2018516624 @default.
- W3119480892 cites W2025625354 @default.
- W3119480892 cites W2026254108 @default.
- W3119480892 cites W2029857102 @default.
- W3119480892 cites W2030787848 @default.
- W3119480892 cites W2032118946 @default.
- W3119480892 cites W2033131290 @default.
- W3119480892 cites W2034373020 @default.
- W3119480892 cites W2035192365 @default.
- W3119480892 cites W2035780143 @default.
- W3119480892 cites W2036571456 @default.
- W3119480892 cites W2037345578 @default.
- W3119480892 cites W2037481552 @default.
- W3119480892 cites W2039797518 @default.
- W3119480892 cites W2041183520 @default.
- W3119480892 cites W2041469012 @default.
- W3119480892 cites W2041827225 @default.
- W3119480892 cites W2042063184 @default.
- W3119480892 cites W2044199226 @default.
- W3119480892 cites W2049346003 @default.
- W3119480892 cites W2051433581 @default.
- W3119480892 cites W2060421182 @default.
- W3119480892 cites W2063197030 @default.
- W3119480892 cites W2064027874 @default.
- W3119480892 cites W2065244533 @default.
- W3119480892 cites W2069505779 @default.
- W3119480892 cites W2069561533 @default.
- W3119480892 cites W2072335762 @default.
- W3119480892 cites W2080480789 @default.
- W3119480892 cites W2081012321 @default.
- W3119480892 cites W2092104384 @default.
- W3119480892 cites W2095086052 @default.
- W3119480892 cites W2095249623 @default.
- W3119480892 cites W2096214657 @default.
- W3119480892 cites W2101889783 @default.
- W3119480892 cites W2104774845 @default.
- W3119480892 cites W2105240743 @default.
- W3119480892 cites W2107987302 @default.
- W3119480892 cites W2111567865 @default.
- W3119480892 cites W2115001053 @default.
- W3119480892 cites W2118625918 @default.
- W3119480892 cites W2120991696 @default.
- W3119480892 cites W2127396827 @default.
- W3119480892 cites W2127860417 @default.
- W3119480892 cites W2128079945 @default.
- W3119480892 cites W2128246136 @default.
- W3119480892 cites W2129555025 @default.
- W3119480892 cites W2131007764 @default.
- W3119480892 cites W2135773027 @default.
- W3119480892 cites W2140177588 @default.
- W3119480892 cites W2144311146 @default.
- W3119480892 cites W2146839729 @default.
- W3119480892 cites W2148018436 @default.
- W3119480892 cites W2148811818 @default.
- W3119480892 cites W2149716131 @default.
- W3119480892 cites W2149987834 @default.
- W3119480892 cites W2150475359 @default.
- W3119480892 cites W2151463502 @default.
- W3119480892 cites W2156780879 @default.
- W3119480892 cites W2169800047 @default.
- W3119480892 cites W2171621406 @default.
- W3119480892 cites W2179115815 @default.
- W3119480892 cites W2196342307 @default.
- W3119480892 cites W2253992326 @default.
- W3119480892 cites W2261100060 @default.