Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119487035> ?p ?o ?g. }
- W3119487035 abstract "Retinal detachment (RD) causes damage, including disjunction, of the rod photoreceptor-bipolar synapse, which disrupts vision and may contribute to the poor visual recovery observed after retinal reattachment surgery. We created a model of iatrogenic RD in adult female pigs to study damage to the rod-bipolar synapse after injury and the ability of a highly specific Rho-kinase (ROCK) inhibitor to preserve synaptic structure and function. This model mimics procedures used in humans when viral vectors or cells are injected subretinally for treatment of retinal disease. Synaptic disjunction by retraction of rod spherules, quantified by image analysis of confocal sections, was present 2 h after detachment and remained 2 days later even though the retina had spontaneously reattached by then. Moreover, spherule retraction occurred in attached retina 1-2 cms from detached retina. Synaptic damage was significantly reduced by ROCK inhibition in detached retina whether injected subretinally or intravitreally. Dark-adapted full-field electroretinograms were recorded in reattached retinas to assess rod-specific function. Reduction in synaptic injury correlated with increases in rod-driven responses in drug-treated eyes. Thus, ROCK inhibition helps prevent synaptic damage and improves functional outcomes after retinal injury and may be a useful adjunctive treatment in iatrogenic RD and other retinal degenerative diseases." @default.
- W3119487035 created "2021-01-18" @default.
- W3119487035 creator A5024623344 @default.
- W3119487035 creator A5038228952 @default.
- W3119487035 creator A5065085849 @default.
- W3119487035 creator A5074824430 @default.
- W3119487035 creator A5076960257 @default.
- W3119487035 creator A5090654043 @default.
- W3119487035 date "2021-01-12" @default.
- W3119487035 modified "2023-09-27" @default.
- W3119487035 title "ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury" @default.
- W3119487035 cites W1524495606 @default.
- W3119487035 cites W1527592097 @default.
- W3119487035 cites W1631556437 @default.
- W3119487035 cites W163911440 @default.
- W3119487035 cites W1868644528 @default.
- W3119487035 cites W1964005024 @default.
- W3119487035 cites W1964169664 @default.
- W3119487035 cites W1967799738 @default.
- W3119487035 cites W1969341357 @default.
- W3119487035 cites W1977627547 @default.
- W3119487035 cites W1978585388 @default.
- W3119487035 cites W1981660619 @default.
- W3119487035 cites W1991851279 @default.
- W3119487035 cites W1993329436 @default.
- W3119487035 cites W1997257234 @default.
- W3119487035 cites W2002304262 @default.
- W3119487035 cites W2003996544 @default.
- W3119487035 cites W2004035553 @default.
- W3119487035 cites W2005226793 @default.
- W3119487035 cites W2005474543 @default.
- W3119487035 cites W2006769576 @default.
- W3119487035 cites W2013854760 @default.
- W3119487035 cites W2024007754 @default.
- W3119487035 cites W2025187912 @default.
- W3119487035 cites W2025928828 @default.
- W3119487035 cites W2026693637 @default.
- W3119487035 cites W2030930681 @default.
- W3119487035 cites W2032554493 @default.
- W3119487035 cites W2034596569 @default.
- W3119487035 cites W2039211870 @default.
- W3119487035 cites W2044844412 @default.
- W3119487035 cites W2051212121 @default.
- W3119487035 cites W2058611989 @default.
- W3119487035 cites W2059313543 @default.
- W3119487035 cites W2060320925 @default.
- W3119487035 cites W2062564048 @default.
- W3119487035 cites W2069093369 @default.
- W3119487035 cites W2070538167 @default.
- W3119487035 cites W2073835675 @default.
- W3119487035 cites W2075195539 @default.
- W3119487035 cites W2075811835 @default.
- W3119487035 cites W2077570009 @default.
- W3119487035 cites W2082775864 @default.
- W3119487035 cites W2085039801 @default.
- W3119487035 cites W2087890288 @default.
- W3119487035 cites W2090777728 @default.
- W3119487035 cites W2090816237 @default.
- W3119487035 cites W2095636909 @default.
- W3119487035 cites W2126605806 @default.
- W3119487035 cites W2128418445 @default.
- W3119487035 cites W2137222303 @default.
- W3119487035 cites W2138507504 @default.
- W3119487035 cites W2144437022 @default.
- W3119487035 cites W2149860264 @default.
- W3119487035 cites W2149884610 @default.
- W3119487035 cites W2151828629 @default.
- W3119487035 cites W2156103849 @default.
- W3119487035 cites W2156128879 @default.
- W3119487035 cites W2161467739 @default.
- W3119487035 cites W2162371883 @default.
- W3119487035 cites W2167772395 @default.
- W3119487035 cites W2167809348 @default.
- W3119487035 cites W2208389916 @default.
- W3119487035 cites W2316257867 @default.
- W3119487035 cites W2426584396 @default.
- W3119487035 cites W2462994663 @default.
- W3119487035 cites W2463338601 @default.
- W3119487035 cites W2518899983 @default.
- W3119487035 cites W2585871472 @default.
- W3119487035 cites W2610328993 @default.
- W3119487035 cites W2624866195 @default.
- W3119487035 cites W2680505683 @default.
- W3119487035 cites W2752641978 @default.
- W3119487035 cites W2791013442 @default.
- W3119487035 cites W2793223065 @default.
- W3119487035 cites W2794763796 @default.
- W3119487035 cites W2795818410 @default.
- W3119487035 cites W2795836363 @default.
- W3119487035 cites W2905588940 @default.
- W3119487035 cites W2908602993 @default.
- W3119487035 cites W2943724291 @default.
- W3119487035 cites W2967637402 @default.
- W3119487035 cites W3004643344 @default.
- W3119487035 doi "https://doi.org/10.1038/s41598-020-80267-4" @default.
- W3119487035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7804129" @default.
- W3119487035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33436892" @default.
- W3119487035 hasPublicationYear "2021" @default.
- W3119487035 type Work @default.
- W3119487035 sameAs 3119487035 @default.