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• W3119489762 abstract "ABSTRACT Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in catalysis or binding display remarkable tolerance to mutation. An exception is a glutamine residue in the AAA+ module (Gln 118) that is not located at a catalytic or interfacial site. Gln 118 forms a hydrogen-bonded junction in a helical unit that we term the central coupler, because it connects the catalytic centers to DNA and the sliding clamp. A suppressor mutation indicates that hydrogen bonding in the junction is important, and molecular dynamics simulations reveal that it maintains rigidity in the central coupler. The glutamine-mediated junction is preserved in diverse AAA+ ATPases, suggesting that a connected network of hydrogen bonds that links ATP molecules is an essential aspect of allosteric communication in these proteins." @default.
• W3119489762 created "2021-01-18" @default.
• W3119489762 creator A5003400828 @default.
• W3119489762 creator A5013005754 @default.
• W3119489762 creator A5027071808 @default.
• W3119489762 creator A5038330393 @default.
• W3119489762 creator A5051770888 @default.
• W3119489762 creator A5062664948 @default.
• W3119489762 creator A5072467973 @default.
• W3119489762 creator A5078047508 @default.
• W3119489762 date "2021-01-02" @default.
• W3119489762 modified "2023-09-27" @default.
• W3119489762 title "Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction" @default.
• W3119489762 cites W1758089766 @default.
• W3119489762 cites W1875835053 @default.
• W3119489762 cites W1956993305 @default.
• W3119489762 cites W1969836007 @default.
• W3119489762 cites W1970663985 @default.
• W3119489762 cites W1970858396 @default.
• W3119489762 cites W1972028650 @default.
• W3119489762 cites W1977131457 @default.
• W3119489762 cites W1980225897 @default.
• W3119489762 cites W1988597925 @default.
• W3119489762 cites W2001138638 @default.
• W3119489762 cites W2001258946 @default.
• W3119489762 cites W2005937630 @default.
• W3119489762 cites W2008166029 @default.
• W3119489762 cites W2010958487 @default.
• W3119489762 cites W2014082836 @default.
• W3119489762 cites W2023012416 @default.
• W3119489762 cites W202706838 @default.
• W3119489762 cites W2028904598 @default.
• W3119489762 cites W2040838256 @default.
• W3119489762 cites W2043542498 @default.
• W3119489762 cites W2046200242 @default.
• W3119489762 cites W2051274733 @default.
• W3119489762 cites W2052065853 @default.
• W3119489762 cites W2053431227 @default.
• W3119489762 cites W2053937911 @default.
• W3119489762 cites W2060588922 @default.
• W3119489762 cites W2061628677 @default.
• W3119489762 cites W2065709249 @default.
• W3119489762 cites W2072747624 @default.
• W3119489762 cites W2077167882 @default.
• W3119489762 cites W2083238898 @default.
• W3119489762 cites W2087318188 @default.
• W3119489762 cites W2088303736 @default.
• W3119489762 cites W2089240028 @default.
• W3119489762 cites W2090695231 @default.
• W3119489762 cites W2093072087 @default.
• W3119489762 cites W2098865666 @default.
• W3119489762 cites W2116537286 @default.
• W3119489762 cites W2120002506 @default.
• W3119489762 cites W2121431496 @default.
• W3119489762 cites W2121992995 @default.
• W3119489762 cites W2123182960 @default.
• W3119489762 cites W2125312640 @default.
• W3119489762 cites W2127886165 @default.
• W3119489762 cites W2138028295 @default.
• W3119489762 cites W2147988069 @default.
• W3119489762 cites W2158266834 @default.
• W3119489762 cites W2160844977 @default.
• W3119489762 cites W2166903547 @default.
• W3119489762 cites W2168240189 @default.
• W3119489762 cites W2196646621 @default.
• W3119489762 cites W2204959575 @default.
• W3119489762 cites W2283974241 @default.
• W3119489762 cites W2293120041 @default.
• W3119489762 cites W2331911623 @default.
• W3119489762 cites W2332712348 @default.
• W3119489762 cites W2335520030 @default.
• W3119489762 cites W2404280981 @default.
• W3119489762 cites W2409777496 @default.
• W3119489762 cites W2423210081 @default.
• W3119489762 cites W2468882414 @default.
• W3119489762 cites W2568452855 @default.
• W3119489762 cites W2574806330 @default.
• W3119489762 cites W2725462383 @default.
• W3119489762 cites W2738359913 @default.
• W3119489762 cites W2747545869 @default.
• W3119489762 cites W2762768319 @default.
• W3119489762 cites W2775204276 @default.
• W3119489762 cites W2801376357 @default.
• W3119489762 cites W2883984694 @default.
• W3119489762 cites W2906494960 @default.
• W3119489762 cites W2921674955 @default.
• W3119489762 cites W2926621447 @default.
• W3119489762 cites W2947574057 @default.
• W3119489762 cites W2950372509 @default.
• W3119489762 cites W2979976361 @default.
• W3119489762 cites W2987740792 @default.
• W3119489762 cites W2998781879 @default.
• W3119489762 cites W3004107745 @default.
• W3119489762 cites W3008938277 @default.
• W3119489762 cites W3084122349 @default.
• W3119489762 cites W3087407932 @default.
• W3119489762 cites W3094223723 @default.
• W3119489762 cites W3094232626 @default.
• W3119489762 cites W3113219874 @default.
• W3119489762 cites W47123523 @default.

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