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• W3119493402 abstract "Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the preservation of bone properties in an exceptionally old black bear that was physically inactive for about 6 months annually for 31 years. The biological mechanisms that preserve bone during prolonged disuse during hibernation are also reviewed." @default.
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• W3119493402 date "2021-04-01" @default.
• W3119493402 modified "2023-10-16" @default.
• W3119493402 title "Osteoporosis prevention in an extraordinary hibernating bear" @default.
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• W3119493402 doi "https://doi.org/10.1016/j.bone.2021.115845" @default.
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