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• W3119519477 abstract "Abstract Background Colorectal adenomatous polyps (CAPs) are considered precancerous lesions of colorectal cancer (CRC). The gut microbiota participates in the process of digestion and, in the process, produces metabolites, mainly short-chain fatty acids (SCFAs), secondary bile acids and conjugated linoleic acid (CLA). This study aimed to investigate the gut microbiota constituents and metabolites in the faeces of CAP patients to identify microbiota or metabolites that can be used as sensitive biological predictors and to provide a theoretical basis for the clinical treatment of CAPs. Methods 16S rRNA sequence analysis was used to detect microbial changes in the faeces of CAP patients. qPCR analysis was used to evaluate the ability of the microbiota to produce metabolites, and the contents of metabolites in faeces were detected by ion chromatography and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Based on the detection of the gut microbiota, patients with CAPs had increased abundances of Bacteroides and Citrobacter , and the abundances of Weissella and Lactobacillus were decreased. We also explored gene expression, and the abundance of butyrate-producing bacterial genes was significantly increased in the faeces of CAP patients, but those of secondary bile acid-producing and CLA-producing bacterial genes showed no differences in faecal samples. The acetic acid and butyric acid contents were increased in the faeces of the CAP group, and the healthy control group had higher t10,c12-CLA contents . Conclusion The gut microbiota analysis results, assessed in faeces, showed that Bacteroides and Citrobacter were positively correlated with CAPs, which indicated that changes in specific genera might be detrimental to intestinal health. In addition, t10,c12-CLA played an important role in protecting the intestine." @default.
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• W3119519477 date "2021-01-12" @default.
• W3119519477 modified "2023-10-18" @default.
• W3119519477 title "Bacteroides, butyric acid and t10,c12-CLA changes in colorectal adenomatous polyp patients" @default.
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• W3119519477 doi "https://doi.org/10.1186/s13099-020-00395-0" @default.
• W3119519477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7805033" @default.
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