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- W3119575220 abstract "Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which has α-glucosidase inhibitory activity, was approved and used in the clinical treatment of diabetes. This study focused on l-iminofuranose derivatives to develop new anti-diabetic drug. As a result, it was found that l-iminofuranose having an alkyl group at C1 position show potent α-glucosidase inhibitory activity. Further structural-activity relationship studies were conducted, and interesting findings were obtained. This paper describes the details of those research developments." @default.
- W3119575220 created "2021-01-18" @default.
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- W3119575220 date "2021-01-01" @default.
- W3119575220 modified "2023-10-16" @default.
- W3119575220 title "Synthesis of L-Iminofuranoses and Their Biological Evaluations" @default.
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- W3119575220 doi "https://doi.org/10.1248/yakushi.20-00194" @default.
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