FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119593168> ?p ?o ?g. }

• W3119593168 endingPage "e0245210" @default.
• W3119593168 startingPage "e0245210" @default.
• W3119593168 abstract "Background Neuron-specific enolase (NSE) and S-100b have been used to assess neurological damage following out-of-hospital cardiac arrest (OHCA). Cut-offs were derived from small normothermic cohorts. Whether similar cut-offs apply to patients treated with hypothermia remained undetermined. Methods We investigated 251 patients with OHCA treated with hypothermia but without routine prognostication. Neuromarkers were determined at day 3, neurological outcome was assessed after hospital discharge by cerebral performance category (CPC). Results Good neurological outcome (CPC≤2) was achieved in 41%. Elevated neuromarkers, older age and absence of ST-segment elevation after ROSC were associated with increased mortality. Poor neurological outcome in survivors was additionally associated with history of cerebrovascular events, sepsis and higher admission lactate. Mean NSE was 33μg/l [16–94] vs. 119μg/l [25–406]; p<0.001, for survivors vs. non-survivors, and 21μg/l [16–29] vs. 40μg/l [23–98], p<0.001 for good vs. poor neurological outcome. S-100b was 0.127μg/l [0.063–0.360] vs. 0.772μg/l [0.121–2.710], p<0.001 and 0.086μg/l [0.061–0.122] vs. 0.138μg/l [0.090–0.271], p = 0.009, respectively. For mortality, thresholds of 36μg/l for NSE and 0.128μg/l for S-100b could be determined; for poor neurological outcome 33μg/l (NSE) and 0.123μg/l (S-100b), respectively. Positive predictive value for NSE was 81% (74–88) and 79% (71–85) for S-100b. Conclusions Thresholds for NSE and S-100b predicting mortality and poor neurological outcome are similar in OHCA patients receiving therapeutic hypothermia as in those reported before the era of hypothermia. However, both biomarkers do not have enough specificity to predict mortality or poor neurological outcome on their own and should only be additively used in clinical decision making." @default.
• W3119593168 created "2021-01-18" @default.
• W3119593168 creator A5002199346 @default.
• W3119593168 creator A5012244560 @default.
• W3119593168 creator A5016118935 @default.
• W3119593168 creator A5038820023 @default.
• W3119593168 creator A5054373408 @default.
• W3119593168 creator A5061885364 @default.
• W3119593168 creator A5071045213 @default.
• W3119593168 date "2021-01-07" @default.
• W3119593168 modified "2023-09-27" @default.
• W3119593168 title "Neuromarkers and neurological outcome in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia–experience from the HAnnover COoling REgistry (HACORE)" @default.
• W3119593168 cites W1740216334 @default.
• W3119593168 cites W1773198732 @default.
• W3119593168 cites W1970612718 @default.
• W3119593168 cites W1983477232 @default.
• W3119593168 cites W2062642814 @default.
• W3119593168 cites W2066679089 @default.
• W3119593168 cites W2081878176 @default.
• W3119593168 cites W2104869294 @default.
• W3119593168 cites W2105397247 @default.
• W3119593168 cites W2153433387 @default.
• W3119593168 cites W2171886225 @default.
• W3119593168 cites W2172418087 @default.
• W3119593168 cites W2574275238 @default.
• W3119593168 cites W2585252480 @default.
• W3119593168 cites W2626946155 @default.
• W3119593168 cites W2738669913 @default.
• W3119593168 cites W2769636059 @default.
• W3119593168 cites W2890802503 @default.
• W3119593168 cites W2891303349 @default.
• W3119593168 cites W2945822374 @default.
• W3119593168 cites W2958510524 @default.
• W3119593168 cites W2982522962 @default.
• W3119593168 cites W3025840238 @default.
• W3119593168 cites W4241203406 @default.
• W3119593168 cites W81660439 @default.
• W3119593168 doi "https://doi.org/10.1371/journal.pone.0245210" @default.
• W3119593168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7790428" @default.
• W3119593168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33411836" @default.
• W3119593168 hasPublicationYear "2021" @default.
• W3119593168 type Work @default.
• W3119593168 sameAs 3119593168 @default.
• W3119593168 citedByCount "9" @default.
• W3119593168 countsByYear W31195931682021 @default.
• W3119593168 countsByYear W31195931682022 @default.
• W3119593168 countsByYear W31195931682023 @default.
• W3119593168 crossrefType "journal-article" @default.
• W3119593168 hasAuthorship W3119593168A5002199346 @default.
• W3119593168 hasAuthorship W3119593168A5012244560 @default.
• W3119593168 hasAuthorship W3119593168A5016118935 @default.
• W3119593168 hasAuthorship W3119593168A5038820023 @default.
• W3119593168 hasAuthorship W3119593168A5054373408 @default.
• W3119593168 hasAuthorship W3119593168A5061885364 @default.
• W3119593168 hasAuthorship W3119593168A5071045213 @default.
• W3119593168 hasBestOaLocation W31195931681 @default.
• W3119593168 hasConcept C126322002 @default.
• W3119593168 hasConcept C188618488 @default.
• W3119593168 hasConcept C204232928 @default.
• W3119593168 hasConcept C2777390192 @default.
• W3119593168 hasConcept C2778384902 @default.
• W3119593168 hasConcept C2993523616 @default.
• W3119593168 hasConcept C42219234 @default.
• W3119593168 hasConcept C71924100 @default.
• W3119593168 hasConceptScore W3119593168C126322002 @default.
• W3119593168 hasConceptScore W3119593168C188618488 @default.
• W3119593168 hasConceptScore W3119593168C204232928 @default.
• W3119593168 hasConceptScore W3119593168C2777390192 @default.
• W3119593168 hasConceptScore W3119593168C2778384902 @default.
• W3119593168 hasConceptScore W3119593168C2993523616 @default.
• W3119593168 hasConceptScore W3119593168C42219234 @default.
• W3119593168 hasConceptScore W3119593168C71924100 @default.
• W3119593168 hasFunder F4320320879 @default.
• W3119593168 hasIssue "1" @default.
• W3119593168 hasLocation W31195931681 @default.
• W3119593168 hasLocation W31195931682 @default.
• W3119593168 hasLocation W31195931683 @default.
• W3119593168 hasOpenAccess W3119593168 @default.
• W3119593168 hasPrimaryLocation W31195931681 @default.
• W3119593168 hasRelatedWork W1534609067 @default.
• W3119593168 hasRelatedWork W1589198926 @default.
• W3119593168 hasRelatedWork W1971846669 @default.
• W3119593168 hasRelatedWork W2050076791 @default.
• W3119593168 hasRelatedWork W2129701354 @default.
• W3119593168 hasRelatedWork W2267190369 @default.
• W3119593168 hasRelatedWork W2370660782 @default.
• W3119593168 hasRelatedWork W2386825874 @default.
• W3119593168 hasRelatedWork W2408010109 @default.
• W3119593168 hasRelatedWork W3119593168 @default.
• W3119593168 hasVolume "16" @default.
• W3119593168 isParatext "false" @default.
• W3119593168 isRetracted "false" @default.
• W3119593168 magId "3119593168" @default.
• W3119593168 workType "article" @default.