FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119624508> ?p ?o ?g. }

• W3119624508 abstract "Abstract Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response to cell perturbation. Activation of T cells, which triggers extensive changes in transcriptional programs, serves as an instructive model to elucidate how changes in chromatin architecture orchestrate gene expression in response to cell perturbation. To characterize coordinate changes at different levels of chromatin architecture, we analyzed chromatin accessibility, chromosome conformation and gene expression in activated human T cells. T cell activation was characterized by widespread changes in chromatin accessibility and interactions that were shared between activated CD4 + and CD8 + T cells, and with the formation of active regulatory regions associated with transcription factors relevant to T cell biology. Chromatin interactions that increased and decreased were coupled, respectively, with up- and down-regulation of corresponding target genes. Furthermore, activation was associated with disruption of long-range chromatin interactions and with partitioning of topologically associating domains (TADs) and remodelling of their TAD boundaries. Newly formed/strengthened TAD boundaries were associated with higher nucleosome occupancy and lower accessibility, linking changes in lower and higher order chromatin architecture. T cell activation exemplifies coordinate multi-level remodelling of chromatin underlying gene transcription." @default.
• W3119624508 created "2021-01-18" @default.
• W3119624508 creator A5003796244 @default.
• W3119624508 creator A5017015446 @default.
• W3119624508 creator A5029645117 @default.
• W3119624508 creator A5044821326 @default.
• W3119624508 creator A5049193991 @default.
• W3119624508 creator A5054647246 @default.
• W3119624508 creator A5054704071 @default.
• W3119624508 creator A5060561576 @default.
• W3119624508 creator A5071725155 @default.
• W3119624508 creator A5081287556 @default.
• W3119624508 creator A5086938314 @default.
• W3119624508 date "2021-01-12" @default.
• W3119624508 modified "2023-09-26" @default.
• W3119624508 title "Multi-level remodelling of chromatin underlying activation of human T cells" @default.
• W3119624508 cites W1490261451 @default.
• W3119624508 cites W1632979552 @default.
• W3119624508 cites W1859117663 @default.
• W3119624508 cites W1862913282 @default.
• W3119624508 cites W1937291806 @default.
• W3119624508 cites W1973062929 @default.
• W3119624508 cites W1979594866 @default.
• W3119624508 cites W1988924112 @default.
• W3119624508 cites W2001042507 @default.
• W3119624508 cites W2014677321 @default.
• W3119624508 cites W2015845481 @default.
• W3119624508 cites W2018363492 @default.
• W3119624508 cites W2047604395 @default.
• W3119624508 cites W2055082742 @default.
• W3119624508 cites W2056198580 @default.
• W3119624508 cites W2061111901 @default.
• W3119624508 cites W2070021921 @default.
• W3119624508 cites W2078059415 @default.
• W3119624508 cites W2080477348 @default.
• W3119624508 cites W2082912595 @default.
• W3119624508 cites W2090037139 @default.
• W3119624508 cites W2095900642 @default.
• W3119624508 cites W2102619694 @default.
• W3119624508 cites W2107018762 @default.
• W3119624508 cites W2108234281 @default.
• W3119624508 cites W2108744961 @default.
• W3119624508 cites W2112541034 @default.
• W3119624508 cites W2114104545 @default.
• W3119624508 cites W2117757143 @default.
• W3119624508 cites W2126551936 @default.
• W3119624508 cites W2130116522 @default.
• W3119624508 cites W2137526110 @default.
• W3119624508 cites W2137929457 @default.
• W3119624508 cites W2138207763 @default.
• W3119624508 cites W2146512944 @default.
• W3119624508 cites W2152325859 @default.
• W3119624508 cites W2161212572 @default.
• W3119624508 cites W2170551349 @default.
• W3119624508 cites W2171808845 @default.
• W3119624508 cites W2259938310 @default.
• W3119624508 cites W2261235911 @default.
• W3119624508 cites W2295297857 @default.
• W3119624508 cites W2323056845 @default.
• W3119624508 cites W2401568148 @default.
• W3119624508 cites W2406250479 @default.
• W3119624508 cites W2466314544 @default.
• W3119624508 cites W2553838260 @default.
• W3119624508 cites W2560265676 @default.
• W3119624508 cites W2584773227 @default.
• W3119624508 cites W2606372763 @default.
• W3119624508 cites W2767110090 @default.
• W3119624508 cites W2770138124 @default.
• W3119624508 cites W2797313452 @default.
• W3119624508 cites W2807301917 @default.
• W3119624508 cites W2837542075 @default.
• W3119624508 cites W2898215009 @default.
• W3119624508 cites W2911510951 @default.
• W3119624508 cites W2949341516 @default.
• W3119624508 cites W2950464315 @default.
• W3119624508 cites W2950801021 @default.
• W3119624508 cites W2952203741 @default.
• W3119624508 cites W2973326578 @default.
• W3119624508 cites W2977079874 @default.
• W3119624508 cites W3099018540 @default.
• W3119624508 doi "https://doi.org/10.1038/s41598-020-80165-9" @default.
• W3119624508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7804404" @default.
• W3119624508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33436846" @default.
• W3119624508 hasPublicationYear "2021" @default.
• W3119624508 type Work @default.
• W3119624508 sameAs 3119624508 @default.
• W3119624508 citedByCount "23" @default.
• W3119624508 countsByYear W31196245082021 @default.
• W3119624508 countsByYear W31196245082022 @default.
• W3119624508 countsByYear W31196245082023 @default.
• W3119624508 crossrefType "journal-article" @default.
• W3119624508 hasAuthorship W3119624508A5003796244 @default.
• W3119624508 hasAuthorship W3119624508A5017015446 @default.
• W3119624508 hasAuthorship W3119624508A5029645117 @default.
• W3119624508 hasAuthorship W3119624508A5044821326 @default.
• W3119624508 hasAuthorship W3119624508A5049193991 @default.
• W3119624508 hasAuthorship W3119624508A5054647246 @default.
• W3119624508 hasAuthorship W3119624508A5054704071 @default.
• W3119624508 hasAuthorship W3119624508A5060561576 @default.
• W3119624508 hasAuthorship W3119624508A5071725155 @default.

• next