FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119637579> ?p ?o ?g. }

• W3119637579 endingPage "123" @default.
• W3119637579 startingPage "116" @default.
• W3119637579 abstract "INTRODUCTION AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional AGXT gene polymorphism in NSCLC progression, considering as primary and secondary endpoint, progression free survival (PFS) and overall survival (OS), respectively. METHODS Genotyping of theAGXT rs34116584 genetic polymorphism was performed by mass spectrometry on 168 DNA samples from patients with NSCLC (stages IIIA-IVB). Univariate survival analysis included the study of Kaplan-Meier curves with the Log-Rank test, while Cox regression was used as a multivariate analysis. RESULTS Multivariate analysis showed shorter PFS for T carriers [HR=2.0, 95% CI, 1.4-3.0, p<0.0001] and shorter OS [HR=1.8, 95% CI, 1.1-3.0, p=0.017] globally, as well as in a subgroup of patients (n=144) treated with first line platinum-based chemotherapy [HR=2.0, 95% CI, 1.3-3.1, p=0.001] and [HR=1.8, 95% CI, 1.1-3.1, p=0.026], respectively. CONCLUSION This polymorphism seems to have an impact on NSCLC progression, opening new perspectives for its inclusion as a pharmacogenetic predictor of response to platinum-based chemotherapy." @default.
• W3119637579 created "2021-01-18" @default.
• W3119637579 creator A5002507025 @default.
• W3119637579 creator A5006305376 @default.
• W3119637579 creator A5025544676 @default.
• W3119637579 creator A5044319140 @default.
• W3119637579 creator A5061444991 @default.
• W3119637579 creator A5061509108 @default.
• W3119637579 creator A5073916274 @default.
• W3119637579 creator A5088120224 @default.
• W3119637579 date "2021-03-01" @default.
• W3119637579 modified "2023-10-17" @default.
• W3119637579 title "Pharmacogenetics of advanced lung cancer: Predictive value of functional genetic polymorphism AGXT Pro11Leu in clinical outcome?" @default.
• W3119637579 cites W1972340856 @default.
• W3119637579 cites W1998634450 @default.
• W3119637579 cites W2050115187 @default.
• W3119637579 cites W2051978340 @default.
• W3119637579 cites W2057707250 @default.
• W3119637579 cites W2057977761 @default.
• W3119637579 cites W2077863592 @default.
• W3119637579 cites W2100434822 @default.
• W3119637579 cites W210176314 @default.
• W3119637579 cites W2109644074 @default.
• W3119637579 cites W2131463822 @default.
• W3119637579 cites W2261766689 @default.
• W3119637579 cites W2270714875 @default.
• W3119637579 cites W2320995203 @default.
• W3119637579 cites W2735708159 @default.
• W3119637579 cites W2762557975 @default.
• W3119637579 cites W2765108097 @default.
• W3119637579 cites W2802659363 @default.
• W3119637579 cites W2807800408 @default.
• W3119637579 cites W2888031957 @default.
• W3119637579 cites W2910873889 @default.
• W3119637579 cites W2967873149 @default.
• W3119637579 cites W2997761377 @default.
• W3119637579 cites W3003499321 @default.
• W3119637579 cites W3010845033 @default.
• W3119637579 cites W74350690 @default.
• W3119637579 doi "https://doi.org/10.1016/j.pulmoe.2020.11.007" @default.
• W3119637579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33408043" @default.
• W3119637579 hasPublicationYear "2021" @default.
• W3119637579 type Work @default.
• W3119637579 sameAs 3119637579 @default.
• W3119637579 citedByCount "5" @default.
• W3119637579 countsByYear W31196375792022 @default.
• W3119637579 countsByYear W31196375792023 @default.
• W3119637579 crossrefType "journal-article" @default.
• W3119637579 hasAuthorship W3119637579A5002507025 @default.
• W3119637579 hasAuthorship W3119637579A5006305376 @default.
• W3119637579 hasAuthorship W3119637579A5025544676 @default.
• W3119637579 hasAuthorship W3119637579A5044319140 @default.
• W3119637579 hasAuthorship W3119637579A5061444991 @default.
• W3119637579 hasAuthorship W3119637579A5061509108 @default.
• W3119637579 hasAuthorship W3119637579A5073916274 @default.
• W3119637579 hasAuthorship W3119637579A5088120224 @default.
• W3119637579 hasBestOaLocation W31196375791 @default.
• W3119637579 hasConcept C104317684 @default.
• W3119637579 hasConcept C126322002 @default.
• W3119637579 hasConcept C135763542 @default.
• W3119637579 hasConcept C143998085 @default.
• W3119637579 hasConcept C149737253 @default.
• W3119637579 hasConcept C2776256026 @default.
• W3119637579 hasConcept C3019719930 @default.
• W3119637579 hasConcept C54355233 @default.
• W3119637579 hasConcept C55775858 @default.
• W3119637579 hasConcept C60644358 @default.
• W3119637579 hasConcept C71924100 @default.
• W3119637579 hasConcept C86803240 @default.
• W3119637579 hasConceptScore W3119637579C104317684 @default.
• W3119637579 hasConceptScore W3119637579C126322002 @default.
• W3119637579 hasConceptScore W3119637579C135763542 @default.
• W3119637579 hasConceptScore W3119637579C143998085 @default.
• W3119637579 hasConceptScore W3119637579C149737253 @default.
• W3119637579 hasConceptScore W3119637579C2776256026 @default.
• W3119637579 hasConceptScore W3119637579C3019719930 @default.
• W3119637579 hasConceptScore W3119637579C54355233 @default.
• W3119637579 hasConceptScore W3119637579C55775858 @default.
• W3119637579 hasConceptScore W3119637579C60644358 @default.
• W3119637579 hasConceptScore W3119637579C71924100 @default.
• W3119637579 hasConceptScore W3119637579C86803240 @default.
• W3119637579 hasIssue "2" @default.
• W3119637579 hasLocation W31196375791 @default.
• W3119637579 hasLocation W31196375792 @default.
• W3119637579 hasOpenAccess W3119637579 @default.
• W3119637579 hasPrimaryLocation W31196375791 @default.
• W3119637579 hasRelatedWork W2062096219 @default.
• W3119637579 hasRelatedWork W2365632055 @default.
• W3119637579 hasRelatedWork W2372561159 @default.
• W3119637579 hasRelatedWork W2375344515 @default.
• W3119637579 hasRelatedWork W2375392632 @default.
• W3119637579 hasRelatedWork W2380382254 @default.
• W3119637579 hasRelatedWork W2390152934 @default.
• W3119637579 hasRelatedWork W2412727163 @default.
• W3119637579 hasRelatedWork W2603922820 @default.
• W3119637579 hasRelatedWork W2735708159 @default.
• W3119637579 hasVolume "27" @default.
• W3119637579 isParatext "false" @default.

• next