Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119647162> ?p ?o ?g. }
- W3119647162 endingPage "163" @default.
- W3119647162 startingPage "146" @default.
- W3119647162 abstract "The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer mitochondrial membrane. TSPO binding, as measured with positron emission tomography (PET), is considered an in vivo marker of neuroinflammation. Indeed, TSPO expression is altered in neurodegenerative, neuroinflammatory, and neuropsychiatric diseases. In PET studies, the TSPO signal is often viewed as a marker of microglial cell activity. However, there is little evidence in support of a microglia-specific TSPO expression. This review describes the cellular sources and functions of TSPO in animal models of disease and human studies, in health, and in central nervous system diseases. A discussion of methods of analysis and of quantification of TSPO is also presented. Overall, it appears that the alterations of TSPO binding, their cellular underpinnings, and the functional significance of such alterations depend on many factors, notably the pathology or the animal model under study, the disease stage, and the involved brain regions. Thus, further studies are needed to fully determine how changes in TSPO binding occur at the cellular level with the ultimate goal of revealing potential therapeutic pathways." @default.
- W3119647162 created "2021-01-18" @default.
- W3119647162 creator A5005548202 @default.
- W3119647162 creator A5032427076 @default.
- W3119647162 creator A5033448398 @default.
- W3119647162 creator A5054158530 @default.
- W3119647162 creator A5056424425 @default.
- W3119647162 creator A5058801218 @default.
- W3119647162 creator A5080983116 @default.
- W3119647162 creator A5082397800 @default.
- W3119647162 date "2021-01-12" @default.
- W3119647162 modified "2023-10-09" @default.
- W3119647162 title "Cellular sources of TSPO expression in healthy and diseased brain" @default.
- W3119647162 cites W1024608467 @default.
- W3119647162 cites W12859958 @default.
- W3119647162 cites W140452898 @default.
- W3119647162 cites W1482554720 @default.
- W3119647162 cites W1507576786 @default.
- W3119647162 cites W1537418123 @default.
- W3119647162 cites W1574200406 @default.
- W3119647162 cites W1592609177 @default.
- W3119647162 cites W1604272930 @default.
- W3119647162 cites W1607206274 @default.
- W3119647162 cites W1640714826 @default.
- W3119647162 cites W1702029570 @default.
- W3119647162 cites W1838986638 @default.
- W3119647162 cites W1859830958 @default.
- W3119647162 cites W1887098316 @default.
- W3119647162 cites W1900110634 @default.
- W3119647162 cites W1964888681 @default.
- W3119647162 cites W1966541444 @default.
- W3119647162 cites W1968531979 @default.
- W3119647162 cites W1969526330 @default.
- W3119647162 cites W1976274224 @default.
- W3119647162 cites W1979263239 @default.
- W3119647162 cites W1980818494 @default.
- W3119647162 cites W1982494368 @default.
- W3119647162 cites W1986304241 @default.
- W3119647162 cites W1988659923 @default.
- W3119647162 cites W1990064835 @default.
- W3119647162 cites W1990912256 @default.
- W3119647162 cites W1994562650 @default.
- W3119647162 cites W1995445966 @default.
- W3119647162 cites W1995458780 @default.
- W3119647162 cites W1996151739 @default.
- W3119647162 cites W1997343602 @default.
- W3119647162 cites W1999924432 @default.
- W3119647162 cites W2004017919 @default.
- W3119647162 cites W2011239875 @default.
- W3119647162 cites W2011577075 @default.
- W3119647162 cites W2014452733 @default.
- W3119647162 cites W2015130097 @default.
- W3119647162 cites W2015228000 @default.
- W3119647162 cites W2018154007 @default.
- W3119647162 cites W2019910837 @default.
- W3119647162 cites W2020426672 @default.
- W3119647162 cites W2022211348 @default.
- W3119647162 cites W2025862036 @default.
- W3119647162 cites W2026245262 @default.
- W3119647162 cites W2029678222 @default.
- W3119647162 cites W2030029215 @default.
- W3119647162 cites W2031094958 @default.
- W3119647162 cites W2031648971 @default.
- W3119647162 cites W2033859172 @default.
- W3119647162 cites W2034450620 @default.
- W3119647162 cites W2035413062 @default.
- W3119647162 cites W2040157249 @default.
- W3119647162 cites W2040500491 @default.
- W3119647162 cites W2043864366 @default.
- W3119647162 cites W2045225121 @default.
- W3119647162 cites W2045231355 @default.
- W3119647162 cites W2045347306 @default.
- W3119647162 cites W2048659521 @default.
- W3119647162 cites W2049736771 @default.
- W3119647162 cites W2050252984 @default.
- W3119647162 cites W2050764050 @default.
- W3119647162 cites W2051325433 @default.
- W3119647162 cites W2053860443 @default.
- W3119647162 cites W2055699536 @default.
- W3119647162 cites W2056472076 @default.
- W3119647162 cites W2057034004 @default.
- W3119647162 cites W2058489218 @default.
- W3119647162 cites W2069121275 @default.
- W3119647162 cites W2069587564 @default.
- W3119647162 cites W2074095731 @default.
- W3119647162 cites W2075819003 @default.
- W3119647162 cites W2076945625 @default.
- W3119647162 cites W2077541192 @default.
- W3119647162 cites W2077628685 @default.
- W3119647162 cites W2079198405 @default.
- W3119647162 cites W2081606553 @default.
- W3119647162 cites W2082822881 @default.
- W3119647162 cites W2083528019 @default.
- W3119647162 cites W2083602732 @default.
- W3119647162 cites W2085492035 @default.
- W3119647162 cites W2086774306 @default.
- W3119647162 cites W2087384563 @default.
- W3119647162 cites W2092411410 @default.