Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119729950> ?p ?o ?g. }
- W3119729950 abstract "Abstract IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii , but its role in innate resistance to this infection is unclear. T. gondii infection promotes increased stromal cell expression of IL-33 and levels of parasite replication correlate with IL-33 release. In response to infection, a subset of innate lymphoid cells (ILC) emerges composed of IL-33R + NK cells and ILC1s. In Rag -/- mice, where NK cells and ILC1 provide an innate mechanism of resistance to T. gondii , the loss of IL-33R reduced ILC responses and increased parasite replication. Furthermore, administration of IL-33 to Rag -/- mice resulted in a marked decrease in parasite burden, increased production of IFN-γ and the recruitment and expansion of inflammatory monocytes associated with parasite control. These protective effects of exogenous IL-33 were dependent on endogenous IL-12p40 and the ability of IL-33 to enhance ILC production of IFN-γ. These results highlight that IL-33 synergizes with IL-12 to promote ILC-mediated resistance to T. gondii ." @default.
- W3119729950 created "2021-01-18" @default.
- W3119729950 creator A5000328837 @default.
- W3119729950 creator A5016391982 @default.
- W3119729950 creator A5027909456 @default.
- W3119729950 creator A5031329520 @default.
- W3119729950 creator A5046669174 @default.
- W3119729950 creator A5061442255 @default.
- W3119729950 creator A5063252123 @default.
- W3119729950 creator A5064693777 @default.
- W3119729950 creator A5083200122 @default.
- W3119729950 creator A5090891575 @default.
- W3119729950 date "2021-01-11" @default.
- W3119729950 modified "2023-09-23" @default.
- W3119729950 title "IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity toToxoplasma gondii" @default.
- W3119729950 cites W1481752884 @default.
- W3119729950 cites W1490258901 @default.
- W3119729950 cites W1525644154 @default.
- W3119729950 cites W1793115003 @default.
- W3119729950 cites W1822954797 @default.
- W3119729950 cites W1910209415 @default.
- W3119729950 cites W1913844335 @default.
- W3119729950 cites W1914210250 @default.
- W3119729950 cites W1925420621 @default.
- W3119729950 cites W1944675847 @default.
- W3119729950 cites W1947939079 @default.
- W3119729950 cites W1964323924 @default.
- W3119729950 cites W1965733902 @default.
- W3119729950 cites W1967448179 @default.
- W3119729950 cites W1967840133 @default.
- W3119729950 cites W1983430686 @default.
- W3119729950 cites W1990083653 @default.
- W3119729950 cites W2000571142 @default.
- W3119729950 cites W2001316686 @default.
- W3119729950 cites W2005410446 @default.
- W3119729950 cites W2010708956 @default.
- W3119729950 cites W2013669259 @default.
- W3119729950 cites W2014133727 @default.
- W3119729950 cites W2028057905 @default.
- W3119729950 cites W2037749979 @default.
- W3119729950 cites W2042622445 @default.
- W3119729950 cites W2064742122 @default.
- W3119729950 cites W2065150051 @default.
- W3119729950 cites W2067873629 @default.
- W3119729950 cites W2074218528 @default.
- W3119729950 cites W2080449595 @default.
- W3119729950 cites W2083206813 @default.
- W3119729950 cites W2084575069 @default.
- W3119729950 cites W2089025478 @default.
- W3119729950 cites W2089208233 @default.
- W3119729950 cites W2096349085 @default.
- W3119729950 cites W2099708557 @default.
- W3119729950 cites W2100091884 @default.
- W3119729950 cites W2102655366 @default.
- W3119729950 cites W2111085423 @default.
- W3119729950 cites W2111200149 @default.
- W3119729950 cites W2117079340 @default.
- W3119729950 cites W2118261210 @default.
- W3119729950 cites W2126901258 @default.
- W3119729950 cites W2127826178 @default.
- W3119729950 cites W2131425187 @default.
- W3119729950 cites W2132709753 @default.
- W3119729950 cites W2134457270 @default.
- W3119729950 cites W2138698993 @default.
- W3119729950 cites W2140590600 @default.
- W3119729950 cites W2145149316 @default.
- W3119729950 cites W2146042377 @default.
- W3119729950 cites W2148079779 @default.
- W3119729950 cites W2152283755 @default.
- W3119729950 cites W2157710399 @default.
- W3119729950 cites W2163824052 @default.
- W3119729950 cites W2170091723 @default.
- W3119729950 cites W2268907643 @default.
- W3119729950 cites W2271642981 @default.
- W3119729950 cites W2342539172 @default.
- W3119729950 cites W2344776862 @default.
- W3119729950 cites W2422818699 @default.
- W3119729950 cites W2470104588 @default.
- W3119729950 cites W2471110308 @default.
- W3119729950 cites W2491168016 @default.
- W3119729950 cites W2513111034 @default.
- W3119729950 cites W2521483984 @default.
- W3119729950 cites W2526684592 @default.
- W3119729950 cites W2609227898 @default.
- W3119729950 cites W2765470992 @default.
- W3119729950 cites W2766380081 @default.
- W3119729950 cites W2780273806 @default.
- W3119729950 cites W2792817623 @default.
- W3119729950 cites W2800666787 @default.
- W3119729950 cites W2889489368 @default.
- W3119729950 cites W2890689561 @default.
- W3119729950 cites W2906480617 @default.
- W3119729950 cites W2919485321 @default.
- W3119729950 cites W2939418291 @default.
- W3119729950 cites W2943399314 @default.
- W3119729950 cites W2945343147 @default.
- W3119729950 cites W2947763143 @default.
- W3119729950 cites W2964955072 @default.
- W3119729950 cites W2965935957 @default.
- W3119729950 cites W3000748576 @default.