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- W3119731844 endingPage "111241" @default.
- W3119731844 startingPage "111241" @default.
- W3119731844 abstract "Considerable researches implicate that the circadian clock regulates the responsive rhythms of organs and sets the orderly aging process of cells indirectly. It influences an array of diverse biological process including intestinal flora, peripheral inflammatory responses, and redox homeostasis. People with sleep disoders and other kinds of circadian disruptions are prone to have vascular aging earlier. Meanwhile, those people are always faced with chronic vascular inflammation. It has not been elucidated that the specific mechanism of the interaction between the circadian system and early vascular aging. To explore the biphasic relationship between vascular aging and the circadian system, we summarize what is linking circadian clock with early vascular aging through four major prospect: inflammatory process, oxidative stress response, intestinal flora, and cellular senescence. Meanwhile, we discuss the hypothesis that the deterioration of circadian rhythms may exacerbate the process of early vascular aging, leading to the cardiovascular diseases. It will help us to provide new ideas for understanding the process of vascular aging and exploring the possible ways to design personalized chronotherapies." @default.
- W3119731844 created "2021-01-18" @default.
- W3119731844 creator A5026295742 @default.
- W3119731844 creator A5031191384 @default.
- W3119731844 creator A5080615813 @default.
- W3119731844 date "2021-04-01" @default.
- W3119731844 modified "2023-09-24" @default.
- W3119731844 title "Research progress on the interaction between circadian clock and early vascular aging" @default.
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