Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119780048> ?p ?o ?g. }
- W3119780048 endingPage "991" @default.
- W3119780048 startingPage "982" @default.
- W3119780048 abstract "Lipopolysaccharide (LPS)-induced liver injury is the main factor in acute liver failure. The current study aims to investigate the protection of limonin, an antioxidant compound from citrus fruit, against LPS-induced liver toxicity and elucidate the potential mechanisms. We found that limonin elevated cell viability and reduced LDH release in LPS-treated HepG2 cells. Limonin also inhibited LPS-induced pyroptosis by inhibiting membrane rupture, reducing ROS generation, and decreasing gasdermin D activation. Moreover, limonin inhibited the formation of a NOD-like receptor protein 3 (NLRP3)/Apoptosis-associated speck-like protein containing a CARD (ASC) complex by reducing the related protein expression and the colocalization cytosolic of NLRP3 and caspase-1 and then suppressed IL-1β maturation. Ultimately, we established LPS-induced hepatotoxicity in vivo by using C57BL/6 mice administrated LPS (10 mg/kg) intraperitoneally and limonin (50 and 100 mg/kg) orally. We found that limonin dereased the serum ALT and AST activity and LDH release and increased the hepatic GSH amount in LPS-treated mice. Additionally, the liver histological evaluation revealed that limonin protects against LPS-induced liver damage. We further demonstrated that limonin ameliorated LPS-induced hepatotoxicity by inhibiting pyroptosis via the NLRP3/gasdermin D signaling pathway. In summary, this study uncovered the mechanism whereby limonin mitigated LPS-induced hepatotoxicity and documented that limonin might be a promising candidate drug for LPS-induced hepatotoxicity." @default.
- W3119780048 created "2021-01-18" @default.
- W3119780048 creator A5022692678 @default.
- W3119780048 creator A5024235005 @default.
- W3119780048 creator A5026984704 @default.
- W3119780048 creator A5035315901 @default.
- W3119780048 creator A5042036900 @default.
- W3119780048 creator A5070060968 @default.
- W3119780048 creator A5071040306 @default.
- W3119780048 creator A5088973635 @default.
- W3119780048 date "2021-01-11" @default.
- W3119780048 modified "2023-10-09" @default.
- W3119780048 title "Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis <i>via</i> NLRP3/Gasdermin D Signaling Pathway" @default.
- W3119780048 cites W1416364033 @default.
- W3119780048 cites W1605844554 @default.
- W3119780048 cites W1847463453 @default.
- W3119780048 cites W1864325817 @default.
- W3119780048 cites W1882905539 @default.
- W3119780048 cites W1927491384 @default.
- W3119780048 cites W1966606100 @default.
- W3119780048 cites W1966625479 @default.
- W3119780048 cites W1982023582 @default.
- W3119780048 cites W1984520240 @default.
- W3119780048 cites W1985538633 @default.
- W3119780048 cites W1985970823 @default.
- W3119780048 cites W1986857805 @default.
- W3119780048 cites W1993976394 @default.
- W3119780048 cites W1999224782 @default.
- W3119780048 cites W2003605139 @default.
- W3119780048 cites W2013481774 @default.
- W3119780048 cites W2014662110 @default.
- W3119780048 cites W2015078052 @default.
- W3119780048 cites W2017007805 @default.
- W3119780048 cites W2040098015 @default.
- W3119780048 cites W2044838232 @default.
- W3119780048 cites W2047166567 @default.
- W3119780048 cites W2067615993 @default.
- W3119780048 cites W2068619092 @default.
- W3119780048 cites W2068970193 @default.
- W3119780048 cites W2073031675 @default.
- W3119780048 cites W2079893663 @default.
- W3119780048 cites W2080827095 @default.
- W3119780048 cites W2089503694 @default.
- W3119780048 cites W2097714951 @default.
- W3119780048 cites W2118403357 @default.
- W3119780048 cites W2118918019 @default.
- W3119780048 cites W2127108097 @default.
- W3119780048 cites W2130843367 @default.
- W3119780048 cites W2135791851 @default.
- W3119780048 cites W2137211177 @default.
- W3119780048 cites W2137573856 @default.
- W3119780048 cites W2138914940 @default.
- W3119780048 cites W2142459639 @default.
- W3119780048 cites W2152034538 @default.
- W3119780048 cites W2155738620 @default.
- W3119780048 cites W2156072340 @default.
- W3119780048 cites W2157551652 @default.
- W3119780048 cites W2171212614 @default.
- W3119780048 cites W2171546468 @default.
- W3119780048 cites W2345872969 @default.
- W3119780048 cites W2380127284 @default.
- W3119780048 cites W2418806051 @default.
- W3119780048 cites W2466539945 @default.
- W3119780048 cites W2561876393 @default.
- W3119780048 cites W2567040191 @default.
- W3119780048 cites W2608687752 @default.
- W3119780048 cites W2732818861 @default.
- W3119780048 cites W2891344942 @default.
- W3119780048 cites W2909653888 @default.
- W3119780048 cites W2966777041 @default.
- W3119780048 cites W3011086993 @default.
- W3119780048 cites W3016555942 @default.
- W3119780048 cites W4211193493 @default.
- W3119780048 cites W4237441880 @default.
- W3119780048 cites W569773320 @default.
- W3119780048 doi "https://doi.org/10.1021/acs.jafc.0c06775" @default.
- W3119780048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33427450" @default.
- W3119780048 hasPublicationYear "2021" @default.
- W3119780048 type Work @default.
- W3119780048 sameAs 3119780048 @default.
- W3119780048 citedByCount "21" @default.
- W3119780048 countsByYear W31197800482021 @default.
- W3119780048 countsByYear W31197800482022 @default.
- W3119780048 countsByYear W31197800482023 @default.
- W3119780048 crossrefType "journal-article" @default.
- W3119780048 hasAuthorship W3119780048A5022692678 @default.
- W3119780048 hasAuthorship W3119780048A5024235005 @default.
- W3119780048 hasAuthorship W3119780048A5026984704 @default.
- W3119780048 hasAuthorship W3119780048A5035315901 @default.
- W3119780048 hasAuthorship W3119780048A5042036900 @default.
- W3119780048 hasAuthorship W3119780048A5070060968 @default.
- W3119780048 hasAuthorship W3119780048A5071040306 @default.
- W3119780048 hasAuthorship W3119780048A5088973635 @default.
- W3119780048 hasConcept C17172800 @default.
- W3119780048 hasConcept C185592680 @default.
- W3119780048 hasConcept C190283241 @default.
- W3119780048 hasConcept C203014093 @default.
- W3119780048 hasConcept C2776137196 @default.