FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119782034> ?p ?o ?g. }

• W3119782034 abstract "Neoadjuvant trials for early breast cancer have accelerated the identification of novel active agents, enabling streamlined conduct of registration trials with fewer subjects. Measurement of neoadjuvant drug effects has also enabled the identification of patients with high risk of distant recurrence and has justified development of additional adjuvant approaches to improve outcomes. Neoadjuvant evaluation of new drugs was significantly improved by the introduction of pathologic complete response (pCR) rate as a quantitative surrogate endpoint for distant disease-free survival (DDFS) and event free survival (EFS). The neoadjuvant phase 2 platform trial I-SPY 2 simultaneously tests multiple drugs across multiple breast cancer subtypes using Bayesian methods of adaptive randomization for assessment of drug efficacy. In addition to the pCR endpoint, the I-SPY 2 trial has demonstrated that the residual cancer burden (RCB) score measures gradations of tumor response that correlate with DDFS and EFS across treatments and subtypes. For HER2-positive and triple-negative breast cancers that have failed to attain pCR with neoadjuvant chemotherapy (NAC), effective modifications of adjuvant treatment have improved outcomes and changed the standard of care for these subtypes. Neoadjuvant therapy is therefore preferred for stage II and III, as well as some stage I, HER2-positive and triple-negative tumors. Neoadjuvant endocrine therapy (NET) strategies have also emerged from innovative trials for stage II and III estrogen receptor (ER)-positive/HER2-negative tumors, as in the ALTERNATE trial. From neoadjuvant trials, opportunities have emerged to de-escalate therapy on the basis of metrics of response to chemotherapy or hormonal therapy. Neoadjuvant therapy for early breast cancer is therefore emerging as a promising approach to accelerate new drug development, optimize treatment strategies, and (where appropriate) de-escalate neoadjuvant therapy." @default.
• W3119782034 created "2021-01-18" @default.
• W3119782034 creator A5033949023 @default.
• W3119782034 creator A5033966004 @default.
• W3119782034 creator A5044258042 @default.
• W3119782034 creator A5047441507 @default.
• W3119782034 creator A5054173606 @default.
• W3119782034 creator A5068040820 @default.
• W3119782034 creator A5074065701 @default.
• W3119782034 creator A5080385299 @default.
• W3119782034 date "2021-01-04" @default.
• W3119782034 modified "2023-10-09" @default.
• W3119782034 title "Recent advances in neoadjuvant therapy for breast cancer" @default.
• W3119782034 cites W1955397179 @default.
• W3119782034 cites W1966804628 @default.
• W3119782034 cites W1979174372 @default.
• W3119782034 cites W1989340541 @default.
• W3119782034 cites W2005494948 @default.
• W3119782034 cites W2021800802 @default.
• W3119782034 cites W2031739694 @default.
• W3119782034 cites W2034505940 @default.
• W3119782034 cites W2038833688 @default.
• W3119782034 cites W2051191349 @default.
• W3119782034 cites W2064086133 @default.
• W3119782034 cites W2075894019 @default.
• W3119782034 cites W2087179076 @default.
• W3119782034 cites W2095633632 @default.
• W3119782034 cites W2095861620 @default.
• W3119782034 cites W2095865154 @default.
• W3119782034 cites W2096145980 @default.
• W3119782034 cites W2097960989 @default.
• W3119782034 cites W2098775844 @default.
• W3119782034 cites W2104919541 @default.
• W3119782034 cites W2111253826 @default.
• W3119782034 cites W2111578514 @default.
• W3119782034 cites W2113435829 @default.
• W3119782034 cites W2114167623 @default.
• W3119782034 cites W2115961074 @default.
• W3119782034 cites W2119549339 @default.
• W3119782034 cites W2123591186 @default.
• W3119782034 cites W2123945948 @default.
• W3119782034 cites W2125589899 @default.
• W3119782034 cites W2128319598 @default.
• W3119782034 cites W2128985829 @default.
• W3119782034 cites W2131267314 @default.
• W3119782034 cites W2134444110 @default.
• W3119782034 cites W2139510434 @default.
• W3119782034 cites W2143346655 @default.
• W3119782034 cites W2144090846 @default.
• W3119782034 cites W2147908679 @default.
• W3119782034 cites W2151262170 @default.
• W3119782034 cites W2153158488 @default.
• W3119782034 cites W2155560234 @default.
• W3119782034 cites W2156556190 @default.
• W3119782034 cites W2159315361 @default.
• W3119782034 cites W2162760540 @default.
• W3119782034 cites W2164774797 @default.
• W3119782034 cites W2165037690 @default.
• W3119782034 cites W2175026167 @default.
• W3119782034 cites W2182711918 @default.
• W3119782034 cites W2263907628 @default.
• W3119782034 cites W2286510717 @default.
• W3119782034 cites W2467606258 @default.
• W3119782034 cites W2471493685 @default.
• W3119782034 cites W2474664935 @default.
• W3119782034 cites W2517421365 @default.
• W3119782034 cites W2536384041 @default.
• W3119782034 cites W2574190322 @default.
• W3119782034 cites W2585697071 @default.
• W3119782034 cites W2587365770 @default.
• W3119782034 cites W2592406193 @default.
• W3119782034 cites W2618058692 @default.
• W3119782034 cites W2620769019 @default.
• W3119782034 cites W2626019450 @default.
• W3119782034 cites W2728674371 @default.
• W3119782034 cites W2772615438 @default.
• W3119782034 cites W2774227900 @default.
• W3119782034 cites W2774580734 @default.
• W3119782034 cites W2788106879 @default.
• W3119782034 cites W2805734855 @default.
• W3119782034 cites W2805968856 @default.
• W3119782034 cites W2887764459 @default.
• W3119782034 cites W2890317046 @default.
• W3119782034 cites W2891728587 @default.
• W3119782034 cites W2899659781 @default.
• W3119782034 cites W2902218997 @default.
• W3119782034 cites W2902672529 @default.
• W3119782034 cites W2912648593 @default.
• W3119782034 cites W2914243257 @default.
• W3119782034 cites W2928807055 @default.
• W3119782034 cites W2941116324 @default.
• W3119782034 cites W2946550606 @default.
• W3119782034 cites W2948923376 @default.
• W3119782034 cites W2954662492 @default.
• W3119782034 cites W2966923691 @default.
• W3119782034 cites W2967434552 @default.
• W3119782034 cites W2992628266 @default.
• W3119782034 cites W2993532690 @default.
• W3119782034 cites W3004461112 @default.
• W3119782034 cites W3005738019 @default.

• next