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• W3119783035 abstract "Despite early childhood weight gain being a key indicator of obesity risk, we do not have a good understanding of the different patterns that exist.To identify and characterise distinct groups of children displaying similar early-life weight trajectories.A growth mixture model captured heterogeneity in weight trajectories between 0 and 60 months in 1390 children in the Avon Longitudinal Study of Parents and Children. Differences between the classes in characteristics and body size/composition at 9 years were investigated.The best model had five classes. The Normal (45%) and Normal after initial catch-down (24%) classes were close to the 50th centile of a growth standard between 24 and 60 months. The High-decreasing (21%) and Stable-high (7%) classes peaked at the ~91st centile at 12-18 months, but while the former declined to the ~75th centile and comprised constitutionally big children, the latter did not. The Rapidly increasing (3%) class gained weight from below the 50th centile at 4 months to above the 91st centile at 60 months. By 9 years, their mean body mass index (BMI) placed them at the 98th centile. This class was characterised by the highest maternal BMI; highest parity; highest levels of gestational hypertension and diabetes; and the lowest socio-economic position. At 9 years, the Rapidly increasing class was estimated to have 68.2% (95% confidence interval [CI] 48.3, 88.1) more fat mass than the Normal class, but only 14.0% (95% CI 9.1, 18.9) more lean mass.Criteria used in growth monitoring practice are unlikely to consistently distinguish between the different patterns of weight gain reported here." @default.
• W3119783035 created "2021-01-18" @default.
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• W3119783035 date "2021-05-07" @default.
• W3119783035 modified "2023-09-27" @default.
• W3119783035 title "Early childhood weight gain: Latent patterns and body composition outcomes" @default.
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• W3119783035 doi "https://doi.org/10.1111/ppe.12754" @default.
• W3119783035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33960515" @default.
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