Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119793314> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3119793314 abstract "Docosahexaenoic acid (DHA) is the predominant omega-3 fatty acid in the brain and has been shown to have neuroprotective effects in Parkinson’s disease, but the underlying mechanism has not been fully elucidated. DHA is metabolized to DHA epoxides (EDPs) and hydroxides by cytochrome P450s (P450s), and EDPs are further hydroxylated to the corresponding diols (DHDPs) by soluble epoxide hydrolase (sEH). In the present study, we investigated the roles of these DHA metabolites in the beneficial effects of DHA supplementation on a rotenone-induced rat model of Parkinson’s disease. Metabolite analysis by LC-MS revealed that CYP2A1, 2C11, 2C13, 2C23, and 2E1 contributed to the formation of EDPs, and these P450s and sEH were expressed in the rat brain. We found that DHA supplementation in rats improved the motor dysfunction induced by rotenone. In addition, DHA reversed the decrease in tyrosine hydroxylase and the increase in lipid peroxidation generated by rotenone in the striatum. DHA supplementation also induced mRNA expression of antioxidant genes and Nrf2 protein expression in the striatum. However, these effects of DHA supplementation were eliminated by cosupplementation with the sEH inhibitor TPPU. DHA metabolites, including EDPs and DHDPs, in the rat brain were analyzed by LC-MS/MS. Supplementation with DHA increased the amount of DHA-diols (DHDPs) in the rat brain, while the amount of EDPs was not significantly increased. In addition, TPPU suppressed the increase in DHDPs and increased EDPs in the brain. These results indicate that DHDPs are important in the beneficial effects of DHA supplementation. The addition of DHDPs to PC12 cells increased the mRNA levels of antioxidant genes along with Nrf2 induction. This study suggests that DHA metabolites—DHDPs generated by P450s and sEH—have an important role in improving rotenone-induced Parkinson’s disease." @default.
- W3119793314 created "2021-01-18" @default.
- W3119793314 creator A5010566917 @default.
- W3119793314 creator A5023699051 @default.
- W3119793314 date "2020-11-30" @default.
- W3119793314 modified "2023-09-25" @default.
- W3119793314 title "Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson’s disease" @default.
- W3119793314 doi "https://doi.org/10.3390/iecbm2020-08583" @default.
- W3119793314 hasPublicationYear "2020" @default.
- W3119793314 type Work @default.
- W3119793314 sameAs 3119793314 @default.
- W3119793314 citedByCount "0" @default.
- W3119793314 crossrefType "proceedings-article" @default.
- W3119793314 hasAuthorship W3119793314A5010566917 @default.
- W3119793314 hasAuthorship W3119793314A5023699051 @default.
- W3119793314 hasBestOaLocation W31197933141 @default.
- W3119793314 hasConcept C126322002 @default.
- W3119793314 hasConcept C134018914 @default.
- W3119793314 hasConcept C185592680 @default.
- W3119793314 hasConcept C19038510 @default.
- W3119793314 hasConcept C25498285 @default.
- W3119793314 hasConcept C2776151105 @default.
- W3119793314 hasConcept C2776925932 @default.
- W3119793314 hasConcept C2777171753 @default.
- W3119793314 hasConcept C2777477808 @default.
- W3119793314 hasConcept C2778004101 @default.
- W3119793314 hasConcept C2778389096 @default.
- W3119793314 hasConcept C2779134260 @default.
- W3119793314 hasConcept C2779734285 @default.
- W3119793314 hasConcept C2780062018 @default.
- W3119793314 hasConcept C28859421 @default.
- W3119793314 hasConcept C513476851 @default.
- W3119793314 hasConcept C543025807 @default.
- W3119793314 hasConcept C55493867 @default.
- W3119793314 hasConcept C71924100 @default.
- W3119793314 hasConcept C86803240 @default.
- W3119793314 hasConcept C98274493 @default.
- W3119793314 hasConceptScore W3119793314C126322002 @default.
- W3119793314 hasConceptScore W3119793314C134018914 @default.
- W3119793314 hasConceptScore W3119793314C185592680 @default.
- W3119793314 hasConceptScore W3119793314C19038510 @default.
- W3119793314 hasConceptScore W3119793314C25498285 @default.
- W3119793314 hasConceptScore W3119793314C2776151105 @default.
- W3119793314 hasConceptScore W3119793314C2776925932 @default.
- W3119793314 hasConceptScore W3119793314C2777171753 @default.
- W3119793314 hasConceptScore W3119793314C2777477808 @default.
- W3119793314 hasConceptScore W3119793314C2778004101 @default.
- W3119793314 hasConceptScore W3119793314C2778389096 @default.
- W3119793314 hasConceptScore W3119793314C2779134260 @default.
- W3119793314 hasConceptScore W3119793314C2779734285 @default.
- W3119793314 hasConceptScore W3119793314C2780062018 @default.
- W3119793314 hasConceptScore W3119793314C28859421 @default.
- W3119793314 hasConceptScore W3119793314C513476851 @default.
- W3119793314 hasConceptScore W3119793314C543025807 @default.
- W3119793314 hasConceptScore W3119793314C55493867 @default.
- W3119793314 hasConceptScore W3119793314C71924100 @default.
- W3119793314 hasConceptScore W3119793314C86803240 @default.
- W3119793314 hasConceptScore W3119793314C98274493 @default.
- W3119793314 hasLocation W31197933141 @default.
- W3119793314 hasOpenAccess W3119793314 @default.
- W3119793314 hasPrimaryLocation W31197933141 @default.
- W3119793314 hasRelatedWork W2007908680 @default.
- W3119793314 hasRelatedWork W2070066327 @default.
- W3119793314 hasRelatedWork W2077035886 @default.
- W3119793314 hasRelatedWork W2146008698 @default.
- W3119793314 hasRelatedWork W2776263972 @default.
- W3119793314 hasRelatedWork W2800143701 @default.
- W3119793314 hasRelatedWork W2892600174 @default.
- W3119793314 hasRelatedWork W2925258395 @default.
- W3119793314 hasRelatedWork W3046417874 @default.
- W3119793314 hasRelatedWork W4308729015 @default.
- W3119793314 isParatext "false" @default.
- W3119793314 isRetracted "false" @default.
- W3119793314 magId "3119793314" @default.
- W3119793314 workType "article" @default.