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- W3119818159 abstract "Diabetes mellitus affects the heart through various mechanisms such as microvascular defects, metabolic abnormalities, autonomic dysfunction and incompatible immune response. Furthermore, it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy (DCM) in the absence of coronary artery disease. As DCM progresses it causes electrical remodeling of the heart, left ventricular dysfunction and heart failure. Electrophysiological changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus patients. In recent studies, significant changes in repolarizing K+ currents, Na+ currents and L-type Ca2+ currents along with impaired Ca2+ homeostasis and defective contractile function have been identified in the diabetic heart. In addition, insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic patients. There are many diagnostic tools and management options for DCM, but it is difficult to detect its development and to effectively prevent its progress. In this review, diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM." @default.
- W3119818159 created "2021-01-18" @default.
- W3119818159 creator A5004837092 @default.
- W3119818159 creator A5041732249 @default.
- W3119818159 creator A5043517487 @default.
- W3119818159 date "2021-01-15" @default.
- W3119818159 modified "2023-10-09" @default.
- W3119818159 title "Diabetes-induced changes in cardiac voltage-gated ion channels" @default.
- W3119818159 cites W1524340510 @default.
- W3119818159 cites W1538422979 @default.
- W3119818159 cites W1558473063 @default.
- W3119818159 cites W1944789111 @default.
- W3119818159 cites W1965151982 @default.
- W3119818159 cites W1965910654 @default.
- W3119818159 cites W1967088741 @default.
- W3119818159 cites W1969650462 @default.
- W3119818159 cites W1970464723 @default.
- W3119818159 cites W1971964036 @default.
- W3119818159 cites W1973576889 @default.
- W3119818159 cites W1978078974 @default.
- W3119818159 cites W1983339409 @default.
- W3119818159 cites W1984482933 @default.
- W3119818159 cites W1989433049 @default.
- W3119818159 cites W1989737975 @default.
- W3119818159 cites W1991514105 @default.
- W3119818159 cites W1991515811 @default.
- W3119818159 cites W1991812659 @default.
- W3119818159 cites W1992467460 @default.
- W3119818159 cites W1994064741 @default.
- W3119818159 cites W1996970038 @default.
- W3119818159 cites W1997883766 @default.
- W3119818159 cites W2006499762 @default.
- W3119818159 cites W2007727324 @default.
- W3119818159 cites W2013495405 @default.
- W3119818159 cites W2017163269 @default.
- W3119818159 cites W2017596484 @default.
- W3119818159 cites W2018681140 @default.
- W3119818159 cites W2020512380 @default.
- W3119818159 cites W2020986777 @default.
- W3119818159 cites W2021206866 @default.
- W3119818159 cites W2021341468 @default.
- W3119818159 cites W2021704663 @default.
- W3119818159 cites W2022669266 @default.
- W3119818159 cites W2025787384 @default.
- W3119818159 cites W2030125206 @default.
- W3119818159 cites W2031604154 @default.
- W3119818159 cites W2033330341 @default.
- W3119818159 cites W2042422714 @default.
- W3119818159 cites W2044919076 @default.
- W3119818159 cites W2046300949 @default.
- W3119818159 cites W2046337843 @default.
- W3119818159 cites W2048243122 @default.
- W3119818159 cites W2048996984 @default.
- W3119818159 cites W2049705063 @default.
- W3119818159 cites W2049860104 @default.
- W3119818159 cites W2051768470 @default.
- W3119818159 cites W2051997552 @default.
- W3119818159 cites W2052143010 @default.
- W3119818159 cites W2053959834 @default.
- W3119818159 cites W2055038470 @default.
- W3119818159 cites W2057406399 @default.
- W3119818159 cites W2058700307 @default.
- W3119818159 cites W2063482843 @default.
- W3119818159 cites W2065288202 @default.
- W3119818159 cites W2066742955 @default.
- W3119818159 cites W2069918300 @default.
- W3119818159 cites W2071704687 @default.
- W3119818159 cites W2071759256 @default.
- W3119818159 cites W2073873832 @default.
- W3119818159 cites W2074860959 @default.
- W3119818159 cites W2075834102 @default.
- W3119818159 cites W2079740539 @default.
- W3119818159 cites W2079747757 @default.
- W3119818159 cites W2080997556 @default.
- W3119818159 cites W2086723643 @default.
- W3119818159 cites W2089723015 @default.
- W3119818159 cites W2092933077 @default.
- W3119818159 cites W2094750001 @default.
- W3119818159 cites W2096056146 @default.
- W3119818159 cites W2098612318 @default.
- W3119818159 cites W2099275093 @default.
- W3119818159 cites W2099587101 @default.
- W3119818159 cites W2101475038 @default.
- W3119818159 cites W2102730253 @default.
- W3119818159 cites W2105230499 @default.
- W3119818159 cites W2110331338 @default.
- W3119818159 cites W2115053151 @default.
- W3119818159 cites W2116644528 @default.
- W3119818159 cites W2117287580 @default.
- W3119818159 cites W2120235933 @default.
- W3119818159 cites W2121912757 @default.
- W3119818159 cites W2122508506 @default.
- W3119818159 cites W2123522154 @default.
- W3119818159 cites W2124492882 @default.
- W3119818159 cites W2126193231 @default.
- W3119818159 cites W2127321192 @default.
- W3119818159 cites W2129912741 @default.
- W3119818159 cites W2130968993 @default.