FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119841569> ?p ?o ?g. }

• W3119841569 endingPage "282" @default.
• W3119841569 startingPage "282" @default.
• W3119841569 abstract "Malignant pleural mesothelioma (MPM) is an aggressive cancer that is causally associated with previous asbestos exposure in most afflicted patients. The prognosis of patients remains dismal, with a median overall survival of only 9–12 months, due to the limited effectiveness of any conventional anti-cancer treatment. New therapeutic strategies are needed to complement the limited armamentarium against MPM. We decided to focus on the combination of different immune checkpoint (IC) blocking antibodies (Abs). Programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), T-cell immunoglobulin mucin-3 (TIM-3), and lymphocyte activation gene-3 (LAG-3) blocking Abs were tested as monotherapies, and as part of a combination strategy with a second IC inhibitor. We investigated their effect in vitro by examining the changes in the immune-related cytokine secretion profile of supernatant collected from treated allogeneic MPM-peripheral blood mononuclear cell (PBMC) co-cultures. Based on our in vitro results of cytokine secretion, and flow cytometry data that showed a significant upregulation of PD-L1 on PBMC after co-culture, we chose to further investigate the combinations of anti PD-L1 + anti TIM-3 versus anti PD-L1 + anti LAG-3 therapies in vivo in the AB1-HA BALB/cJ mesothelioma mouse model. PD-L1 monotherapy, as well as its combination with LAG-3 blockade, resulted in in-vivo delayed tumor growth and significant survival benefit." @default.
• W3119841569 created "2021-01-18" @default.
• W3119841569 creator A5010292675 @default.
• W3119841569 creator A5013881555 @default.
• W3119841569 creator A5026684098 @default.
• W3119841569 creator A5032025948 @default.
• W3119841569 creator A5035019670 @default.
• W3119841569 creator A5056727791 @default.
• W3119841569 creator A5069580321 @default.
• W3119841569 creator A5085722313 @default.
• W3119841569 date "2021-01-14" @default.
• W3119841569 modified "2023-09-24" @default.
• W3119841569 title "The Search for an Interesting Partner to Combine with PD-L1 Blockade in Mesothelioma: Focus on TIM-3 and LAG-3" @default.
• W3119841569 cites W1863626134 @default.
• W3119841569 cites W1959662613 @default.
• W3119841569 cites W1992444203 @default.
• W3119841569 cites W2007890844 @default.
• W3119841569 cites W2016789384 @default.
• W3119841569 cites W2028763115 @default.
• W3119841569 cites W2031301510 @default.
• W3119841569 cites W2040333460 @default.
• W3119841569 cites W2066671159 @default.
• W3119841569 cites W2094366129 @default.
• W3119841569 cites W2102627969 @default.
• W3119841569 cites W2112601576 @default.
• W3119841569 cites W2129967236 @default.
• W3119841569 cites W2139591061 @default.
• W3119841569 cites W2143163879 @default.
• W3119841569 cites W2149121521 @default.
• W3119841569 cites W2166662937 @default.
• W3119841569 cites W2418354692 @default.
• W3119841569 cites W2527905628 @default.
• W3119841569 cites W2529904548 @default.
• W3119841569 cites W2546670928 @default.
• W3119841569 cites W2768133017 @default.
• W3119841569 cites W2779658193 @default.
• W3119841569 cites W2794163856 @default.
• W3119841569 cites W2803061034 @default.
• W3119841569 cites W2886921565 @default.
• W3119841569 cites W2908887190 @default.
• W3119841569 cites W2909198142 @default.
• W3119841569 cites W2939240280 @default.
• W3119841569 cites W2951153979 @default.
• W3119841569 cites W2961828421 @default.
• W3119841569 cites W2967093625 @default.
• W3119841569 cites W2969325454 @default.
• W3119841569 cites W3049151577 @default.
• W3119841569 doi "https://doi.org/10.3390/cancers13020282" @default.
• W3119841569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7838786" @default.
• W3119841569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33466653" @default.
• W3119841569 hasPublicationYear "2021" @default.
• W3119841569 type Work @default.
• W3119841569 sameAs 3119841569 @default.
• W3119841569 citedByCount "17" @default.
• W3119841569 countsByYear W31198415692021 @default.
• W3119841569 countsByYear W31198415692022 @default.
• W3119841569 countsByYear W31198415692023 @default.
• W3119841569 crossrefType "journal-article" @default.
• W3119841569 hasAuthorship W3119841569A5010292675 @default.
• W3119841569 hasAuthorship W3119841569A5013881555 @default.
• W3119841569 hasAuthorship W3119841569A5026684098 @default.
• W3119841569 hasAuthorship W3119841569A5032025948 @default.
• W3119841569 hasAuthorship W3119841569A5035019670 @default.
• W3119841569 hasAuthorship W3119841569A5056727791 @default.
• W3119841569 hasAuthorship W3119841569A5069580321 @default.
• W3119841569 hasAuthorship W3119841569A5085722313 @default.
• W3119841569 hasBestOaLocation W31198415691 @default.
• W3119841569 hasConcept C121608353 @default.
• W3119841569 hasConcept C126322002 @default.
• W3119841569 hasConcept C137061746 @default.
• W3119841569 hasConcept C142724271 @default.
• W3119841569 hasConcept C150903083 @default.
• W3119841569 hasConcept C159654299 @default.
• W3119841569 hasConcept C170493617 @default.
• W3119841569 hasConcept C202751555 @default.
• W3119841569 hasConcept C203014093 @default.
• W3119841569 hasConcept C207001950 @default.
• W3119841569 hasConcept C2777407522 @default.
• W3119841569 hasConcept C2777701055 @default.
• W3119841569 hasConcept C2778326572 @default.
• W3119841569 hasConcept C2778468042 @default.
• W3119841569 hasConcept C2778690821 @default.
• W3119841569 hasConcept C2780851360 @default.
• W3119841569 hasConcept C2781053074 @default.
• W3119841569 hasConcept C45121317 @default.
• W3119841569 hasConcept C502942594 @default.
• W3119841569 hasConcept C553184892 @default.
• W3119841569 hasConcept C55493867 @default.
• W3119841569 hasConcept C71924100 @default.
• W3119841569 hasConcept C86803240 @default.
• W3119841569 hasConcept C8891405 @default.
• W3119841569 hasConceptScore W3119841569C121608353 @default.
• W3119841569 hasConceptScore W3119841569C126322002 @default.
• W3119841569 hasConceptScore W3119841569C137061746 @default.
• W3119841569 hasConceptScore W3119841569C142724271 @default.
• W3119841569 hasConceptScore W3119841569C150903083 @default.
• W3119841569 hasConceptScore W3119841569C159654299 @default.
• W3119841569 hasConceptScore W3119841569C170493617 @default.

• next