Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119876647> ?p ?o ?g. }
- W3119876647 endingPage "108425" @default.
- W3119876647 startingPage "108425" @default.
- W3119876647 abstract "The aim of this study was to monitor inflammatory, proliferative and progressive effects of proliferative vitreoretinopathy (PVR) and aflibercept treatment in dispase induced PVR rat model by proteomic analysis. A total of 35 male Long Evans pigmented rats were divided into three groups, namely, PVR (dispase+saline), PVR+aflibercept (dispase+aflibercept) and control. The PVR group received 2 μl of 0.03 IU/μl dispase and 2 μl saline, the PVR+aflibercept group received 2 μl of 0.03 IU/μl and 2 μl of 40 mg/ml aflibercept at the first day of the experiment. At the end of the 6th week all retina and vitreous specimens were collected by evisceration and transferred to the proteomics laboratory for analysis. Proteomic analysis by 2D gel electrophoresis coupled with MALDI-TOF/TOF was performed. In the PVR and PVR+aflibercept group 16 different proteins that were identified to be differentially regulated in comparison to the control group. In the PVR+aflibercept group, ENO1, ENO2, LDH-B, PEBP-1 and GS levels were higher than the PVR group. In addition, the association of proteins such as UCHL, PEBP1, PDHB and ENO1 with PVR has been demonstrated for the first time. STRING analysis elucidated the functional protein-protein interaction among the differentially regulated proteins and highlighted that those proteins mainly played roles in carbon and nucleotide metabolisms. Functional analysis of the differentially regulated proteins indicated the presence of inflammation, gliosis and retinal damage in the PVR group. Aflibercept treatment had pronounced effect on prevention of inflammation and retinal damage while causing a slight increase in gliosis. However, aflibercept treatment was not effective enough to normalize the levels of differentially regulated proteins of the PVR group. Therefore, we predict that the treatment dose of aflibercept used in this study was below of its ideal concentration and should be increased in the future studies. The differential regulation of these structural proteins in this study should shed some light to the mechanism of glial wound formation in the retina and guide future treatment modalities." @default.
- W3119876647 created "2021-01-18" @default.
- W3119876647 creator A5006316350 @default.
- W3119876647 creator A5035328929 @default.
- W3119876647 creator A5040890946 @default.
- W3119876647 creator A5050376668 @default.
- W3119876647 creator A5077597772 @default.
- W3119876647 date "2021-02-01" @default.
- W3119876647 modified "2023-09-30" @default.
- W3119876647 title "Effect of aflibercept on proliferative vitreoretinopathy: Proteomic analysis in an experimental animal model" @default.
- W3119876647 cites W1171995885 @default.
- W3119876647 cites W1861582625 @default.
- W3119876647 cites W1965097080 @default.
- W3119876647 cites W1967206508 @default.
- W3119876647 cites W1968889541 @default.
- W3119876647 cites W1969411640 @default.
- W3119876647 cites W1974693157 @default.
- W3119876647 cites W1983861137 @default.
- W3119876647 cites W1986827812 @default.
- W3119876647 cites W1987489169 @default.
- W3119876647 cites W1988962517 @default.
- W3119876647 cites W1989318272 @default.
- W3119876647 cites W1989889286 @default.
- W3119876647 cites W1999213916 @default.
- W3119876647 cites W2005751496 @default.
- W3119876647 cites W2006751212 @default.
- W3119876647 cites W2010394020 @default.
- W3119876647 cites W2015447367 @default.
- W3119876647 cites W2016007619 @default.
- W3119876647 cites W2016750928 @default.
- W3119876647 cites W2032402152 @default.
- W3119876647 cites W2040963109 @default.
- W3119876647 cites W2044151597 @default.
- W3119876647 cites W2047858191 @default.
- W3119876647 cites W2063466136 @default.
- W3119876647 cites W2064391449 @default.
- W3119876647 cites W2072162133 @default.
- W3119876647 cites W2073980565 @default.
- W3119876647 cites W2074140561 @default.
- W3119876647 cites W2080786018 @default.
- W3119876647 cites W2083008063 @default.
- W3119876647 cites W2084728729 @default.
- W3119876647 cites W2087422168 @default.
- W3119876647 cites W2093044616 @default.
- W3119876647 cites W2095098250 @default.
- W3119876647 cites W2096173332 @default.
- W3119876647 cites W2101540446 @default.
- W3119876647 cites W2102463203 @default.
- W3119876647 cites W2114232337 @default.
- W3119876647 cites W2127191482 @default.
- W3119876647 cites W2140538253 @default.
- W3119876647 cites W2142982212 @default.
- W3119876647 cites W2145885621 @default.
- W3119876647 cites W2145951786 @default.
- W3119876647 cites W2164518567 @default.
- W3119876647 cites W2197312515 @default.
- W3119876647 cites W2264321694 @default.
- W3119876647 cites W2331023963 @default.
- W3119876647 cites W2460910380 @default.
- W3119876647 cites W2524122176 @default.
- W3119876647 cites W2535939126 @default.
- W3119876647 cites W2552491411 @default.
- W3119876647 cites W2588427561 @default.
- W3119876647 cites W2608011009 @default.
- W3119876647 cites W2615646156 @default.
- W3119876647 cites W2624286428 @default.
- W3119876647 cites W2981768728 @default.
- W3119876647 cites W3024351878 @default.
- W3119876647 cites W4256281895 @default.
- W3119876647 cites W984462502 @default.
- W3119876647 doi "https://doi.org/10.1016/j.exer.2020.108425" @default.
- W3119876647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33417914" @default.
- W3119876647 hasPublicationYear "2021" @default.
- W3119876647 type Work @default.
- W3119876647 sameAs 3119876647 @default.
- W3119876647 citedByCount "5" @default.
- W3119876647 countsByYear W31198766472022 @default.
- W3119876647 countsByYear W31198766472023 @default.
- W3119876647 crossrefType "journal-article" @default.
- W3119876647 hasAuthorship W3119876647A5006316350 @default.
- W3119876647 hasAuthorship W3119876647A5035328929 @default.
- W3119876647 hasAuthorship W3119876647A5040890946 @default.
- W3119876647 hasAuthorship W3119876647A5050376668 @default.
- W3119876647 hasAuthorship W3119876647A5077597772 @default.
- W3119876647 hasConcept C126322002 @default.
- W3119876647 hasConcept C153911025 @default.
- W3119876647 hasConcept C181199279 @default.
- W3119876647 hasConcept C2776694085 @default.
- W3119876647 hasConcept C2777802072 @default.
- W3119876647 hasConcept C2778394429 @default.
- W3119876647 hasConcept C2778749236 @default.
- W3119876647 hasConcept C2779059073 @default.
- W3119876647 hasConcept C2780374859 @default.
- W3119876647 hasConcept C2780428090 @default.
- W3119876647 hasConcept C2780827179 @default.
- W3119876647 hasConcept C55493867 @default.
- W3119876647 hasConcept C71924100 @default.
- W3119876647 hasConcept C86803240 @default.