FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119925059> ?p ?o ?g. }

• W3119925059 endingPage "707" @default.
• W3119925059 startingPage "681" @default.
• W3119925059 abstract "Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4,5-bisphosphate [PI(4,5)P2] composes only 1-2 mol% of total PM lipids. With its synthesis and turnover both spatially and temporally regulated, PI(4,5)P2 recruits and interacts with hundreds of cellular proteins to support a broad spectrum of cellular functions. Several factors contribute to the versatile and dynamic distribution of PI(4,5)P2 in membranes. Physiological multivalent cations such as Ca2+ and Mg2+ can bridge between PI(4,5)P2 headgroups, forming nanoscopic PI(4,5)P2-cation clusters. The distinct lipid environment surrounding PI(4,5)P2 affects the degree of PI(4,5)P2 clustering. In addition, diverse cellular proteins interacting with PI(4,5)P2 can further regulate PI(4,5)P2 lateral distribution and accessibility. This review summarizes the current understanding of PI(4,5)P2 behavior in both cells and model membranes, with emphasis on both multivalent cation- and protein-induced PI(4,5)P2 clustering. Understanding the nature of spatially separated pools of PI(4,5)P2 is fundamental to cell biology." @default.
• W3119925059 created "2021-01-18" @default.
• W3119925059 creator A5018878185 @default.
• W3119925059 creator A5063759089 @default.
• W3119925059 creator A5088660634 @default.
• W3119925059 date "2021-06-20" @default.
• W3119925059 modified "2023-10-16" @default.
• W3119925059 title "PI(4,5)P₂ Clustering and Its Impact on Biological Functions" @default.
• W3119925059 cites W1502324353 @default.
• W3119925059 cites W1520164098 @default.
• W3119925059 cites W1538989554 @default.
• W3119925059 cites W1553348486 @default.
• W3119925059 cites W1585602885 @default.
• W3119925059 cites W1588803833 @default.
• W3119925059 cites W1592924504 @default.
• W3119925059 cites W1595351795 @default.
• W3119925059 cites W1625094297 @default.
• W3119925059 cites W1643436907 @default.
• W3119925059 cites W1658011747 @default.
• W3119925059 cites W16821239 @default.
• W3119925059 cites W1896660650 @default.
• W3119925059 cites W1939198418 @default.
• W3119925059 cites W1968976298 @default.
• W3119925059 cites W1970039699 @default.
• W3119925059 cites W1971712225 @default.
• W3119925059 cites W1971803548 @default.
• W3119925059 cites W1972005066 @default.
• W3119925059 cites W1974098805 @default.
• W3119925059 cites W1974925709 @default.
• W3119925059 cites W1977412572 @default.
• W3119925059 cites W1977951612 @default.
• W3119925059 cites W1978302530 @default.
• W3119925059 cites W1979148327 @default.
• W3119925059 cites W1983769291 @default.
• W3119925059 cites W1985764146 @default.
• W3119925059 cites W1987246337 @default.
• W3119925059 cites W1988472239 @default.
• W3119925059 cites W1989262163 @default.
• W3119925059 cites W1991212867 @default.
• W3119925059 cites W1991496878 @default.
• W3119925059 cites W1991898819 @default.
• W3119925059 cites W1992036259 @default.
• W3119925059 cites W1996576521 @default.
• W3119925059 cites W1997133275 @default.
• W3119925059 cites W1997784032 @default.
• W3119925059 cites W1998176459 @default.
• W3119925059 cites W1998624086 @default.
• W3119925059 cites W1998846966 @default.
• W3119925059 cites W2002243207 @default.
• W3119925059 cites W2007426142 @default.
• W3119925059 cites W2008680889 @default.
• W3119925059 cites W2009924094 @default.
• W3119925059 cites W2012462364 @default.
• W3119925059 cites W2013233930 @default.
• W3119925059 cites W2019759867 @default.
• W3119925059 cites W2020046630 @default.
• W3119925059 cites W2022964566 @default.
• W3119925059 cites W2023839513 @default.
• W3119925059 cites W2026463319 @default.
• W3119925059 cites W2027231986 @default.
• W3119925059 cites W2031361243 @default.
• W3119925059 cites W2032372404 @default.
• W3119925059 cites W2032582749 @default.
• W3119925059 cites W2033303282 @default.
• W3119925059 cites W2033607105 @default.
• W3119925059 cites W2034263106 @default.
• W3119925059 cites W2035095021 @default.
• W3119925059 cites W2036539000 @default.
• W3119925059 cites W2041519837 @default.
• W3119925059 cites W2042015318 @default.
• W3119925059 cites W2043312574 @default.
• W3119925059 cites W2047768215 @default.
• W3119925059 cites W2047989785 @default.
• W3119925059 cites W2050984420 @default.
• W3119925059 cites W2052823811 @default.
• W3119925059 cites W2054418156 @default.
• W3119925059 cites W2054530444 @default.
• W3119925059 cites W2057712924 @default.
• W3119925059 cites W2058366779 @default.
• W3119925059 cites W2059053859 @default.
• W3119925059 cites W2059591462 @default.
• W3119925059 cites W2061831882 @default.
• W3119925059 cites W2062627843 @default.
• W3119925059 cites W2063613016 @default.
• W3119925059 cites W2067216245 @default.
• W3119925059 cites W2067265041 @default.
• W3119925059 cites W2067729473 @default.
• W3119925059 cites W2068877244 @default.
• W3119925059 cites W2070750255 @default.
• W3119925059 cites W2072698183 @default.
• W3119925059 cites W2074070818 @default.
• W3119925059 cites W2076607425 @default.
• W3119925059 cites W2078748790 @default.
• W3119925059 cites W2081618928 @default.
• W3119925059 cites W2082688327 @default.
• W3119925059 cites W2085369522 @default.
• W3119925059 cites W2087613179 @default.
• W3119925059 cites W2088307357 @default.

• next