Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119954850> ?p ?o ?g. }
- W3119954850 endingPage "111566" @default.
- W3119954850 startingPage "111566" @default.
- W3119954850 abstract "Multidrug resistance (MDR) is a major clinical issue leading to substantial reductions in the intracellular levels of anticancer drugs. To overcome MDR, stimulus-responsive polymeric nanotherapeutics that facilitate drug release and cellular uptake at target sites have emerged as promising tools for safe and effective cancer treatment. Among these nanotherapeutics, reactive oxygen species (ROS)-responsive nanocapsules are ideal carriers, as abnormally increased ROS levels can drive controlled drug release at target sites. In this study, we developed novel, high ROS-responsive carboxylated ferrocene nanocapsules (CFNCs) using solvents of different polarities for effective multidrug-resistant cancer therapy. The CFNCs were prepared via the self-assembly of an amphiphilic carboxylated ferrocene polymer composed of a hydrophilic COOH segment and a hydrophobic ferrocenylmethyl methacrylate segment possessing a ROS-responsive group. The size and ROS sensitivity of self-assembled CFNCs could be controlled by using solvents of different polarities during the simple nanoprecipitation process. The CFNCs showed a high loading content (approximately 30 wt%) and on-demand release of paclitaxel under both normal and tumor-mimicking conditions, and exhibited synergistic anticancer effects in multidrug-resistant colorectal cancer cells (HCT-15). Our findings suggest that CFNCs can be applied as carriers for effective cancer therapy." @default.
- W3119954850 created "2021-01-18" @default.
- W3119954850 creator A5031430569 @default.
- W3119954850 creator A5048115781 @default.
- W3119954850 creator A5048200527 @default.
- W3119954850 creator A5048857079 @default.
- W3119954850 date "2021-04-01" @default.
- W3119954850 modified "2023-10-15" @default.
- W3119954850 title "Novel carboxylated ferrocene polymer nanocapsule with high reactive oxygen species sensitivity and on-demand drug release for effective cancer therapy" @default.
- W3119954850 cites W1884243320 @default.
- W3119954850 cites W1993059855 @default.
- W3119954850 cites W2011984934 @default.
- W3119954850 cites W2025221196 @default.
- W3119954850 cites W2028236823 @default.
- W3119954850 cites W2035092706 @default.
- W3119954850 cites W2035253718 @default.
- W3119954850 cites W2038375609 @default.
- W3119954850 cites W2038636572 @default.
- W3119954850 cites W2043296016 @default.
- W3119954850 cites W2044286655 @default.
- W3119954850 cites W2051024356 @default.
- W3119954850 cites W2066411725 @default.
- W3119954850 cites W2073055302 @default.
- W3119954850 cites W2083870878 @default.
- W3119954850 cites W2083887808 @default.
- W3119954850 cites W2108094585 @default.
- W3119954850 cites W2161431747 @default.
- W3119954850 cites W2164841185 @default.
- W3119954850 cites W2166285205 @default.
- W3119954850 cites W2169829820 @default.
- W3119954850 cites W2190837461 @default.
- W3119954850 cites W2321828396 @default.
- W3119954850 cites W2324033578 @default.
- W3119954850 cites W2345376818 @default.
- W3119954850 cites W2410933689 @default.
- W3119954850 cites W2438292910 @default.
- W3119954850 cites W2520215770 @default.
- W3119954850 cites W2557837281 @default.
- W3119954850 cites W2566865170 @default.
- W3119954850 cites W2576633329 @default.
- W3119954850 cites W2584129734 @default.
- W3119954850 cites W2586637063 @default.
- W3119954850 cites W2748405917 @default.
- W3119954850 cites W2785462855 @default.
- W3119954850 cites W2794040960 @default.
- W3119954850 cites W2803250325 @default.
- W3119954850 cites W2885428696 @default.
- W3119954850 cites W2888418938 @default.
- W3119954850 cites W2937680163 @default.
- W3119954850 cites W2981002433 @default.
- W3119954850 cites W2985562150 @default.
- W3119954850 cites W3004233217 @default.
- W3119954850 doi "https://doi.org/10.1016/j.colsurfb.2021.111566" @default.
- W3119954850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33485085" @default.
- W3119954850 hasPublicationYear "2021" @default.
- W3119954850 type Work @default.
- W3119954850 sameAs 3119954850 @default.
- W3119954850 citedByCount "7" @default.
- W3119954850 countsByYear W31199548502021 @default.
- W3119954850 countsByYear W31199548502022 @default.
- W3119954850 countsByYear W31199548502023 @default.
- W3119954850 crossrefType "journal-article" @default.
- W3119954850 hasAuthorship W3119954850A5031430569 @default.
- W3119954850 hasAuthorship W3119954850A5048115781 @default.
- W3119954850 hasAuthorship W3119954850A5048200527 @default.
- W3119954850 hasAuthorship W3119954850A5048857079 @default.
- W3119954850 hasConcept C121608353 @default.
- W3119954850 hasConcept C12554922 @default.
- W3119954850 hasConcept C126322002 @default.
- W3119954850 hasConcept C13245373 @default.
- W3119954850 hasConcept C133936738 @default.
- W3119954850 hasConcept C147789679 @default.
- W3119954850 hasConcept C155672457 @default.
- W3119954850 hasConcept C15920480 @default.
- W3119954850 hasConcept C171250308 @default.
- W3119954850 hasConcept C17525397 @default.
- W3119954850 hasConcept C178790620 @default.
- W3119954850 hasConcept C182606246 @default.
- W3119954850 hasConcept C185592680 @default.
- W3119954850 hasConcept C192562407 @default.
- W3119954850 hasConcept C204399865 @default.
- W3119954850 hasConcept C21951064 @default.
- W3119954850 hasConcept C2777237805 @default.
- W3119954850 hasConcept C2777292972 @default.
- W3119954850 hasConcept C2779820397 @default.
- W3119954850 hasConcept C2780035454 @default.
- W3119954850 hasConcept C48349386 @default.
- W3119954850 hasConcept C501593827 @default.
- W3119954850 hasConcept C521977710 @default.
- W3119954850 hasConcept C52859227 @default.
- W3119954850 hasConcept C55493867 @default.
- W3119954850 hasConcept C67407626 @default.
- W3119954850 hasConcept C71924100 @default.
- W3119954850 hasConcept C79879829 @default.
- W3119954850 hasConcept C86803240 @default.
- W3119954850 hasConcept C96232424 @default.
- W3119954850 hasConcept C98274493 @default.
- W3119954850 hasConceptScore W3119954850C121608353 @default.