FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119961199> ?p ?o ?g. }

• W3119961199 endingPage "1802" @default.
• W3119961199 startingPage "1792" @default.
• W3119961199 abstract "The aim of this study was the comprehensive characterisation of longitudinal clinical, electrophysiological and neuroimaging measures in type III and IV adult spinal muscular atrophy (SMA) with a view to propose objective monitoring markers for future clinical trials. Fourteen type III or IV SMA patients underwent standardised assessments including muscle strength testing, functional evaluation (SMAFRS and MFM), MUNIX (abductor pollicis brevis, APB; abductor digiti minimi, ADM; deltoid; tibialis anterior, TA; trapezius) and quantitative cervical spinal cord MRI to appraise segmental grey and white matter atrophy. Patients underwent a follow-up assessment with the same protocol 24 months later. Longitudinal comparisons were conducted using the Wilcoxon-test for matched data. Responsiveness was estimated using standardized response means (SRM) and a composite score was generated based on the three most significant variables. Significant functional decline was observed based on SMAFRS (p = 0.019), pinch and knee flexion strength (p = 0.030 and 0.027), MUNIX and MUSIX value in the ADM (p = 0.0006 and 0.043) and in TA muscle (p = 0.025). No significant differences were observed based on cervical MRI measures. A significant reduction was detected in the composite score (p = 0.0005, SRM = −1.52), which was the most responsive variable and required a smaller number of patients than single variables in the estimation of sample size for clinical trials. Quantitative strength testing, SMAFRS and MUNIX readily capture disease progression in adult SMA patients. Composite multimodal scores increase predictive value and may reduce sample size requirements in clinical trials." @default.
• W3119961199 created "2021-01-18" @default.
• W3119961199 creator A5004501662 @default.
• W3119961199 creator A5006151659 @default.
• W3119961199 creator A5006189680 @default.
• W3119961199 creator A5006396072 @default.
• W3119961199 creator A5016990492 @default.
• W3119961199 creator A5017408833 @default.
• W3119961199 creator A5018913953 @default.
• W3119961199 creator A5020348717 @default.
• W3119961199 creator A5027654969 @default.
• W3119961199 creator A5030832976 @default.
• W3119961199 creator A5050689401 @default.
• W3119961199 creator A5053155119 @default.
• W3119961199 creator A5057078027 @default.
• W3119961199 creator A5067355239 @default.
• W3119961199 creator A5070798104 @default.
• W3119961199 date "2021-01-02" @default.
• W3119961199 modified "2023-10-18" @default.
• W3119961199 title "Development of new outcome measures for adult SMA type III and IV: a multimodal longitudinal study" @default.
• W3119961199 cites W113797418 @default.
• W3119961199 cites W1966218392 @default.
• W3119961199 cites W1978567675 @default.
• W3119961199 cites W1980477780 @default.
• W3119961199 cites W1988861747 @default.
• W3119961199 cites W2007954199 @default.
• W3119961199 cites W2008628221 @default.
• W3119961199 cites W2034854805 @default.
• W3119961199 cites W2039353696 @default.
• W3119961199 cites W2082994316 @default.
• W3119961199 cites W2083443475 @default.
• W3119961199 cites W2086265339 @default.
• W3119961199 cites W2091911853 @default.
• W3119961199 cites W2100421796 @default.
• W3119961199 cites W2115472083 @default.
• W3119961199 cites W2119820612 @default.
• W3119961199 cites W2143097947 @default.
• W3119961199 cites W2161309912 @default.
• W3119961199 cites W2161381370 @default.
• W3119961199 cites W2167007132 @default.
• W3119961199 cites W2262770833 @default.
• W3119961199 cites W2309887726 @default.
• W3119961199 cites W2345836284 @default.
• W3119961199 cites W2528727157 @default.
• W3119961199 cites W2606128815 @default.
• W3119961199 cites W2606866670 @default.
• W3119961199 cites W2607657850 @default.
• W3119961199 cites W2765253110 @default.
• W3119961199 cites W2770254801 @default.
• W3119961199 cites W2771903066 @default.
• W3119961199 cites W2789114047 @default.
• W3119961199 cites W2799593202 @default.
• W3119961199 cites W2803035370 @default.
• W3119961199 cites W2811369183 @default.
• W3119961199 cites W2883738174 @default.
• W3119961199 cites W2891007096 @default.
• W3119961199 cites W2895705226 @default.
• W3119961199 cites W2901782370 @default.
• W3119961199 cites W2903109975 @default.
• W3119961199 cites W2903344422 @default.
• W3119961199 cites W2922524878 @default.
• W3119961199 cites W2924086781 @default.
• W3119961199 cites W2937644559 @default.
• W3119961199 cites W2958891751 @default.
• W3119961199 cites W2963963144 @default.
• W3119961199 cites W2964951098 @default.
• W3119961199 cites W2970643581 @default.
• W3119961199 doi "https://doi.org/10.1007/s00415-020-10332-5" @default.
• W3119961199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33388927" @default.
• W3119961199 hasPublicationYear "2021" @default.
• W3119961199 type Work @default.
• W3119961199 sameAs 3119961199 @default.
• W3119961199 citedByCount "13" @default.
• W3119961199 countsByYear W31199611992021 @default.
• W3119961199 countsByYear W31199611992022 @default.
• W3119961199 countsByYear W31199611992023 @default.
• W3119961199 crossrefType "journal-article" @default.
• W3119961199 hasAuthorship W3119961199A5004501662 @default.
• W3119961199 hasAuthorship W3119961199A5006151659 @default.
• W3119961199 hasAuthorship W3119961199A5006189680 @default.
• W3119961199 hasAuthorship W3119961199A5006396072 @default.
• W3119961199 hasAuthorship W3119961199A5016990492 @default.
• W3119961199 hasAuthorship W3119961199A5017408833 @default.
• W3119961199 hasAuthorship W3119961199A5018913953 @default.
• W3119961199 hasAuthorship W3119961199A5020348717 @default.
• W3119961199 hasAuthorship W3119961199A5027654969 @default.
• W3119961199 hasAuthorship W3119961199A5030832976 @default.
• W3119961199 hasAuthorship W3119961199A5050689401 @default.
• W3119961199 hasAuthorship W3119961199A5053155119 @default.
• W3119961199 hasAuthorship W3119961199A5057078027 @default.
• W3119961199 hasAuthorship W3119961199A5067355239 @default.
• W3119961199 hasAuthorship W3119961199A5070798104 @default.
• W3119961199 hasBestOaLocation W31199611992 @default.
• W3119961199 hasConcept C105795698 @default.
• W3119961199 hasConcept C114614502 @default.
• W3119961199 hasConcept C126322002 @default.
• W3119961199 hasConcept C126838900 @default.
• W3119961199 hasConcept C129848803 @default.

• next