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- W3119973322 abstract "Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and represents a classic paradigm of inflammation-related cancer. Various inflammation-related risk factors jointly contribute to the development of chronic inflammation in the liver. Chronic inflammation, in turn, leads to continuous cycles of destruction-regeneration in the liver, contributing to HCC development and progression. Tumor associated macrophages are abundant in the tumor microenvironment of HCC, promoting chronic inflammation and HCC progression. Hence, better understanding of the mechanism by which tumor associated macrophages contribute to the pathogenesis of HCC would allow for the development of novel macrophage-targeting immunotherapies. This review summarizes the current knowledge regarding the mechanisms by which macrophages promote HCC development and progression, as well as information from ongoing therapies and clinical trials assessing the efficacy of macrophage-modulating therapies in HCC patients." @default.
- W3119973322 created "2021-01-18" @default.
- W3119973322 creator A5014261420 @default.
- W3119973322 creator A5024421837 @default.
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- W3119973322 creator A5040597182 @default.
- W3119973322 creator A5040946407 @default.
- W3119973322 creator A5045933784 @default.
- W3119973322 date "2021-01-01" @default.
- W3119973322 modified "2023-10-14" @default.
- W3119973322 title "The Role of Tumor Associated Macrophages in Hepatocellular Carcinoma" @default.
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