Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119981091> ?p ?o ?g. }
- W3119981091 abstract "SUMMARY Depletion of architectural factors globally alters chromatin structure, but only modestly affects gene expression. We revisit the structure-function relationship using the inactive X chromosome (Xi) as a model. We investigate cohesin imbalances by forcing its depletion or retention using degron-tagged RAD21 (cohesin subunit) or WAPL (cohesin release factor). Interestingly, cohesin loss disrupts Xi superstructure, unveiling superloops between escapee genes, with minimal effect on gene repression. By contrast, forced cohesin retention markedly affects Xi superstructure and compromises spreading of Xist RNA-Polycomb complexes, attenuating Xi silencing. Effects are greatest at distal chromosomal ends, where looping contacts with the Xist locus are weakened. Surprisingly, cohesin loss created an “Xi superloop” and cohesin retention created “Xi megadomains” on the active X. Across the genome, a proper cohesin balance protects against aberrant inter-chromosomal interactions and tempers Polycomb-mediated repression. We conclude that a balance of cohesin eviction and retention regulates X-inactivation and inter-chromosomal interactions across the genome." @default.
- W3119981091 created "2021-01-18" @default.
- W3119981091 creator A5007941136 @default.
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- W3119981091 creator A5033546706 @default.
- W3119981091 creator A5042459630 @default.
- W3119981091 date "2021-01-13" @default.
- W3119981091 modified "2023-09-27" @default.
- W3119981091 title "Effects of forced cohesin eviction and retention on X-inactivation and autosomes" @default.
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