Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119985004> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3119985004 abstract "Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. While its etiology remains elusive, current understanding suggests a multifactorial process with contributions by genetic, immunologic, hormonal, and environmental factors. A hypothesis that combines several of these factors proposes that genomic elements, the L1 retrotransposons, are instrumental in SLE pathogenesis. L1 retroelements are transcriptionally activated in SLE and produce two proteins, ORF1p and ORF2p, which are immunogenic and can drive type I interferon (IFN) production by producing DNA species that activate cytosolic DNA sensors. In addition, these two proteins reside in RNA-rich macromolecular assemblies that also contain well-known SLE autoantigens like Ro60. We surmise that cells expressing L1 will exhibit all the hallmarks of cells infected by a virus, resulting in a cellular and humoral immune response similar to those in chronic viral infections. However, unlike exogenous viruses, L1 retroelements cannot be eliminated from the host genome. Hence, dysregulated L1 will cause a chronic, but perhaps episodic, challenge for the immune system. The clinical and immunological features of SLE can be at least partly explained by this model. Here we review the support for, and the gaps in, this hypothesis of SLE and its potential for new diagnostic, prognostic, and therapeutic options in SLE." @default.
- W3119985004 created "2021-01-18" @default.
- W3119985004 creator A5059779329 @default.
- W3119985004 creator A5069794289 @default.
- W3119985004 date "2021-01-04" @default.
- W3119985004 modified "2023-09-26" @default.
- W3119985004 title "Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus" @default.
- W3119985004 hasPublicationYear "2021" @default.
- W3119985004 type Work @default.
- W3119985004 sameAs 3119985004 @default.
- W3119985004 citedByCount "0" @default.
- W3119985004 crossrefType "posted-content" @default.
- W3119985004 hasAuthorship W3119985004A5059779329 @default.
- W3119985004 hasAuthorship W3119985004A5069794289 @default.
- W3119985004 hasConcept C104317684 @default.
- W3119985004 hasConcept C121346293 @default.
- W3119985004 hasConcept C141231307 @default.
- W3119985004 hasConcept C142724271 @default.
- W3119985004 hasConcept C159654299 @default.
- W3119985004 hasConcept C203014093 @default.
- W3119985004 hasConcept C2775915377 @default.
- W3119985004 hasConcept C2779075594 @default.
- W3119985004 hasConcept C2779134260 @default.
- W3119985004 hasConcept C2780130043 @default.
- W3119985004 hasConcept C2780942790 @default.
- W3119985004 hasConcept C4918238 @default.
- W3119985004 hasConcept C54355233 @default.
- W3119985004 hasConcept C7029365 @default.
- W3119985004 hasConcept C71924100 @default.
- W3119985004 hasConcept C86803240 @default.
- W3119985004 hasConcept C8891405 @default.
- W3119985004 hasConceptScore W3119985004C104317684 @default.
- W3119985004 hasConceptScore W3119985004C121346293 @default.
- W3119985004 hasConceptScore W3119985004C141231307 @default.
- W3119985004 hasConceptScore W3119985004C142724271 @default.
- W3119985004 hasConceptScore W3119985004C159654299 @default.
- W3119985004 hasConceptScore W3119985004C203014093 @default.
- W3119985004 hasConceptScore W3119985004C2775915377 @default.
- W3119985004 hasConceptScore W3119985004C2779075594 @default.
- W3119985004 hasConceptScore W3119985004C2779134260 @default.
- W3119985004 hasConceptScore W3119985004C2780130043 @default.
- W3119985004 hasConceptScore W3119985004C2780942790 @default.
- W3119985004 hasConceptScore W3119985004C4918238 @default.
- W3119985004 hasConceptScore W3119985004C54355233 @default.
- W3119985004 hasConceptScore W3119985004C7029365 @default.
- W3119985004 hasConceptScore W3119985004C71924100 @default.
- W3119985004 hasConceptScore W3119985004C86803240 @default.
- W3119985004 hasConceptScore W3119985004C8891405 @default.
- W3119985004 hasLocation W31199850041 @default.
- W3119985004 hasOpenAccess W3119985004 @default.
- W3119985004 hasPrimaryLocation W31199850041 @default.
- W3119985004 hasRelatedWork W134325678 @default.
- W3119985004 hasRelatedWork W2010675399 @default.
- W3119985004 hasRelatedWork W2019965289 @default.
- W3119985004 hasRelatedWork W2043398584 @default.
- W3119985004 hasRelatedWork W2053754255 @default.
- W3119985004 hasRelatedWork W2075715794 @default.
- W3119985004 hasRelatedWork W2079387614 @default.
- W3119985004 hasRelatedWork W2106008289 @default.
- W3119985004 hasRelatedWork W2481344698 @default.
- W3119985004 hasRelatedWork W2807112637 @default.
- W3119985004 hasRelatedWork W2894136468 @default.
- W3119985004 hasRelatedWork W2911690924 @default.
- W3119985004 hasRelatedWork W2927571326 @default.
- W3119985004 hasRelatedWork W2941874833 @default.
- W3119985004 hasRelatedWork W2944420606 @default.
- W3119985004 hasRelatedWork W2958364987 @default.
- W3119985004 hasRelatedWork W2959269521 @default.
- W3119985004 hasRelatedWork W3031409406 @default.
- W3119985004 hasRelatedWork W3131778595 @default.
- W3119985004 hasRelatedWork W3190120708 @default.
- W3119985004 isParatext "false" @default.
- W3119985004 isRetracted "false" @default.
- W3119985004 magId "3119985004" @default.
- W3119985004 workType "article" @default.