FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120000736> ?p ?o ?g. }

• W3120000736 endingPage "2396" @default.
• W3120000736 startingPage "2387" @default.
• W3120000736 abstract "Imaging markers of cerebrovascular disease and Alzheimer’s disease (AD) are implicated in mobility impairment in older adults, but few studies have examined these relationships longitudinally in a racially-diverse population-based sample. At Visit 5 (2011–13) of the ARIC Study, 1859 participants had usual pace gait speed (cm/s) assessed and brain MRI (mean age = 76.3, 28.5% Black) and PET (n = 343; mean age = 75.9, 42.6% Black) measures including total/regional brain volume (cm3), white matter hyperintensities (WMH; cm3), infarcts (present/absent), microbleeds (count) and global beta-amyloid (Aβ). Participants returned at Visit 6 (n = 1264, 2016–17) and Visit 7 (n = 1108, 2018–19) for follow-up gait speed assessments. We used linear regression to estimate effects of baseline infarct presence, higher microbleed count, and a one interquartile range (IQR) poorer measures of continuous predictors (−1 IQR total brain volume, temporal-parietal lobe meta region of interest(ROI); +1 IQR WMH volume, global Aβ SUVR) on cross-sectional gait speed and change in gait speed adjusting for age, sex, education, study site, APOE e4, estimated intracranial volume, BMI, and cardiovascular risk factors. Cross-sectionally, slower gait speed outcome was associated with higher WMH volume, −3.38 cm/s (95%CI:-4.71, −2.04), infarct presence, −5.60 cm/s (−7.69, −3.51), microbleed count, −2.20 cm/s (−3.20, −0.91), smaller total brain volume, −9.26 cm/s (−12.1, −6.43), and smaller temporal-parietal lobe ROI -6.28 cm/s (−8.28, −4.28). Longitudinally, faster gait speed outcome decline was associated with higher WMH volume, −0.27 cm/s/year, (−0.51, −0.03) and higher global Aβ SUVR, −0.62 cm/s/year (−1.20, −0.03). Both cerebrovascular and AD pathology may contribute to mobility decline commonly seen with aging." @default.
• W3120000736 created "2021-01-18" @default.
• W3120000736 creator A5000090216 @default.
• W3120000736 creator A5000122559 @default.
• W3120000736 creator A5005099850 @default.
• W3120000736 creator A5005832202 @default.
• W3120000736 creator A5022550187 @default.
• W3120000736 creator A5040599069 @default.
• W3120000736 creator A5041816938 @default.
• W3120000736 creator A5057805928 @default.
• W3120000736 creator A5064540155 @default.
• W3120000736 creator A5070112971 @default.
• W3120000736 creator A5073757153 @default.
• W3120000736 creator A5075741409 @default.
• W3120000736 creator A5087274421 @default.
• W3120000736 date "2021-01-13" @default.
• W3120000736 modified "2023-10-16" @default.
• W3120000736 title "Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study" @default.
• W3120000736 cites W1482694899 @default.
• W3120000736 cites W1518815626 @default.
• W3120000736 cites W1519631919 @default.
• W3120000736 cites W1937979756 @default.
• W3120000736 cites W1966821136 @default.
• W3120000736 cites W1971727242 @default.
• W3120000736 cites W1978843018 @default.
• W3120000736 cites W1980645205 @default.
• W3120000736 cites W1994133638 @default.
• W3120000736 cites W2002925074 @default.
• W3120000736 cites W2018007042 @default.
• W3120000736 cites W2019972472 @default.
• W3120000736 cites W2030195877 @default.
• W3120000736 cites W2031181228 @default.
• W3120000736 cites W2060762518 @default.
• W3120000736 cites W2066438775 @default.
• W3120000736 cites W2069270259 @default.
• W3120000736 cites W2080205373 @default.
• W3120000736 cites W2097258989 @default.
• W3120000736 cites W2100091063 @default.
• W3120000736 cites W2104247279 @default.
• W3120000736 cites W2110999135 @default.
• W3120000736 cites W2112573938 @default.
• W3120000736 cites W2116868098 @default.
• W3120000736 cites W2159296038 @default.
• W3120000736 cites W2160884592 @default.
• W3120000736 cites W2171477682 @default.
• W3120000736 cites W2195457766 @default.
• W3120000736 cites W2239344903 @default.
• W3120000736 cites W2258095556 @default.
• W3120000736 cites W2316138036 @default.
• W3120000736 cites W2411354803 @default.
• W3120000736 cites W2460653397 @default.
• W3120000736 cites W2468738364 @default.
• W3120000736 cites W2523105407 @default.
• W3120000736 cites W2523754777 @default.
• W3120000736 cites W2547883796 @default.
• W3120000736 cites W2549644052 @default.
• W3120000736 cites W2555816435 @default.
• W3120000736 cites W2564061307 @default.
• W3120000736 cites W2582661451 @default.
• W3120000736 cites W2586065273 @default.
• W3120000736 cites W2586751175 @default.
• W3120000736 cites W2620446307 @default.
• W3120000736 cites W2754391392 @default.
• W3120000736 cites W2765887879 @default.
• W3120000736 cites W2771858618 @default.
• W3120000736 cites W2784289637 @default.
• W3120000736 cites W2790084051 @default.
• W3120000736 cites W2887988655 @default.
• W3120000736 cites W2967318538 @default.
• W3120000736 doi "https://doi.org/10.1007/s11682-020-00435-y" @default.
• W3120000736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33439369" @default.
• W3120000736 hasPublicationYear "2021" @default.
• W3120000736 type Work @default.
• W3120000736 sameAs 3120000736 @default.
• W3120000736 citedByCount "11" @default.
• W3120000736 countsByYear W31200007362021 @default.
• W3120000736 countsByYear W31200007362022 @default.
• W3120000736 countsByYear W31200007362023 @default.
• W3120000736 crossrefType "journal-article" @default.
• W3120000736 hasAuthorship W3120000736A5000090216 @default.
• W3120000736 hasAuthorship W3120000736A5000122559 @default.
• W3120000736 hasAuthorship W3120000736A5005099850 @default.
• W3120000736 hasAuthorship W3120000736A5005832202 @default.
• W3120000736 hasAuthorship W3120000736A5022550187 @default.
• W3120000736 hasAuthorship W3120000736A5040599069 @default.
• W3120000736 hasAuthorship W3120000736A5041816938 @default.
• W3120000736 hasAuthorship W3120000736A5057805928 @default.
• W3120000736 hasAuthorship W3120000736A5064540155 @default.
• W3120000736 hasAuthorship W3120000736A5070112971 @default.
• W3120000736 hasAuthorship W3120000736A5073757153 @default.
• W3120000736 hasAuthorship W3120000736A5075741409 @default.
• W3120000736 hasAuthorship W3120000736A5087274421 @default.
• W3120000736 hasBestOaLocation W31200007362 @default.
• W3120000736 hasConcept C118552586 @default.
• W3120000736 hasConcept C119060515 @default.
• W3120000736 hasConcept C126322002 @default.
• W3120000736 hasConcept C126838900 @default.
• W3120000736 hasConcept C143409427 @default.

• next