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- W3120013377 abstract "Abstract Background To determine the utility of chest radiography (CXR) for assessing and prognosticating COVID-19 disease with an objective radiographic scoring system. Methods A multicenter, prospective study was conducted, forty patients were included. Seventy-eight CXR’s were performed on the first derivation cohort of twenty patients with COVID-19 (median age 47.5 years, 10 females and four with comorbidities) admitted between 22 January 2020 and 1 February 2020. Each CXR was scored by three radiologists in consensus and graded on a 72-point COVID-19 Radiographic Score (CRS). This was correlated with supplemental oxygen requirement, C-reactive protein (CRP), lactate dehydrogenase (LDH) and lymphocyte count. To validate our findings, the parameters of another validation cohort of twenty patients with 65 CXRs were analysed. Results In the derivation cohort, seven patients needed supplemental oxygen and one was intubated for mechanical ventilation with no death. The maximum CRS was significantly different between patients on and not on supplemental oxygen (p=<.001). There was strong correlation between maximum CRS and lowest oxygen saturation (r= -.849), maximum CRP (r= .832) and maximum LDH (r= .873). These findings were consistent in the validation cohort. An increment of 2 points in CRS had an accuracy of 0.938 with 100.0% sensitivity (95% CI 100.0-100.0) and 83.3% (95% CI 65.1-100.0) specificity in predicting supplemental oxygen requirement. Conclusion Using an objective scoring system (CRS), the degree of abnormalities on CXR correlates closely with known markers of disease severity. CRS may further be applied to predict patients who require oxygen supplementation during the course of their disease." @default.
- W3120013377 created "2021-01-18" @default.
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- W3120013377 date "2020-04-08" @default.
- W3120013377 modified "2023-10-17" @default.
- W3120013377 title "Chest radiography to assess and prognosticate COVID-19" @default.
- W3120013377 doi "https://doi.org/10.21203/rs.3.rs-21854/v1" @default.
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