FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120097089> ?p ?o ?g. }

• W3120097089 endingPage "158875" @default.
• W3120097089 startingPage "158875" @default.
• W3120097089 abstract "The α-tocopherol-derived long-chain metabolite (α-LCM) α-13′-carboxychromanol (α-13′-COOH) is formed via enzymatic degradation of α-tocopherol (α-TOH) in the liver. In the last decade, α-13′-COOH has emerged as a new regulatory metabolite revealing more potent or even different effects compared with its vitamin precursor α-TOH. The detection of α-13′-COOH in human serum has further strengthened the concept of its physiological relevance as a potential regulatory molecule. Here, we present a new facet on the interaction of α-13′-COOH with macrophage foam cell formation. We found that α-13′-COOH (5 μM) increases angiopoietin-like 4 (ANGPTL4) mRNA expression in human THP-1 macrophages in a time- and dose-dependent manner, while α-TOH (100 μM) showed no effects. Interestingly, the mRNA level of lipoprotein lipase (LPL) was not influenced by α-13′-COOH, but α-TOH treatment led to a reduction of LPL mRNA expression. Both compounds also revealed different effects on protein level: while α-13′-COOH reduced the secreted amount of LPL protein via induction of ANGPTL4 cleavage, i.e. activation, the secreted amount of LPL in the α-TOH-treated samples was diminished due to the inhibition of mRNA expression. In line with this, both compounds reduced the catalytic activity of LPL. However, α-13′-COOH but not α-TOH attenuated VLDL-induced lipid accumulation by 35%. In conclusion, only α-13′-COOH revealed possible antiatherogenic effects due to the reduction of VLDL-induced foam cell formation in THP-1 macrophages. Our results provide further evidence for the role of α-13′-COOH as a functional metabolite of its vitamin E precursor." @default.
• W3120097089 created "2021-01-18" @default.
• W3120097089 creator A5016282627 @default.
• W3120097089 creator A5018383046 @default.
• W3120097089 creator A5063602616 @default.
• W3120097089 creator A5031217205 @default.
• W3120097089 date "2021-04-01" @default.
• W3120097089 modified "2023-09-25" @default.
• W3120097089 title "The vitamin E long-chain metabolite α-13′-COOH affects macrophage foam cell formation via modulation of the lipoprotein lipase system" @default.
• W3120097089 cites W1494611500 @default.
• W3120097089 cites W1525062280 @default.
• W3120097089 cites W1841159787 @default.
• W3120097089 cites W1921122390 @default.
• W3120097089 cites W1966037066 @default.
• W3120097089 cites W1973094863 @default.
• W3120097089 cites W1981346198 @default.
• W3120097089 cites W1983724939 @default.
• W3120097089 cites W1985952418 @default.
• W3120097089 cites W1989900621 @default.
• W3120097089 cites W1990277717 @default.
• W3120097089 cites W1992446914 @default.
• W3120097089 cites W1992766601 @default.
• W3120097089 cites W1993783493 @default.
• W3120097089 cites W1995969505 @default.
• W3120097089 cites W1998303860 @default.
• W3120097089 cites W2006986579 @default.
• W3120097089 cites W2008962463 @default.
• W3120097089 cites W2021681950 @default.
• W3120097089 cites W2027030929 @default.
• W3120097089 cites W2028558940 @default.
• W3120097089 cites W2029863970 @default.
• W3120097089 cites W2035216298 @default.
• W3120097089 cites W2049135972 @default.
• W3120097089 cites W2055480626 @default.
• W3120097089 cites W2059120300 @default.
• W3120097089 cites W2059507357 @default.
• W3120097089 cites W2075357023 @default.
• W3120097089 cites W2077545788 @default.
• W3120097089 cites W2077662173 @default.
• W3120097089 cites W2081860696 @default.
• W3120097089 cites W2084614862 @default.
• W3120097089 cites W2103618523 @default.
• W3120097089 cites W2105362864 @default.
• W3120097089 cites W2105566302 @default.
• W3120097089 cites W2109559983 @default.
• W3120097089 cites W2110944832 @default.
• W3120097089 cites W2115509231 @default.
• W3120097089 cites W2126047917 @default.
• W3120097089 cites W2126273261 @default.
• W3120097089 cites W2128469803 @default.
• W3120097089 cites W2137731448 @default.
• W3120097089 cites W2141939352 @default.
• W3120097089 cites W2145642828 @default.
• W3120097089 cites W2155278362 @default.
• W3120097089 cites W2160521357 @default.
• W3120097089 cites W2162382529 @default.
• W3120097089 cites W2171433116 @default.
• W3120097089 cites W2286634515 @default.
• W3120097089 cites W2286999219 @default.
• W3120097089 cites W2327038295 @default.
• W3120097089 cites W2331756138 @default.
• W3120097089 cites W2334579686 @default.
• W3120097089 cites W2417423427 @default.
• W3120097089 cites W2528112982 @default.
• W3120097089 cites W2544920402 @default.
• W3120097089 cites W2548612387 @default.
• W3120097089 cites W2743451334 @default.
• W3120097089 cites W2758793990 @default.
• W3120097089 cites W2782954296 @default.
• W3120097089 cites W2795254585 @default.
• W3120097089 cites W2802653781 @default.
• W3120097089 cites W2884453662 @default.
• W3120097089 cites W2921662581 @default.
• W3120097089 cites W2951256923 @default.
• W3120097089 cites W3011425156 @default.
• W3120097089 doi "https://doi.org/10.1016/j.bbalip.2021.158875" @default.
• W3120097089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33421592" @default.
• W3120097089 hasPublicationYear "2021" @default.
• W3120097089 type Work @default.
• W3120097089 sameAs 3120097089 @default.
• W3120097089 citedByCount "6" @default.
• W3120097089 countsByYear W31200970892021 @default.
• W3120097089 countsByYear W31200970892022 @default.
• W3120097089 countsByYear W31200970892023 @default.
• W3120097089 crossrefType "journal-article" @default.
• W3120097089 hasAuthorship W3120097089A5016282627 @default.
• W3120097089 hasAuthorship W3120097089A5018383046 @default.
• W3120097089 hasAuthorship W3120097089A5031217205 @default.
• W3120097089 hasAuthorship W3120097089A5063602616 @default.
• W3120097089 hasConcept C181199279 @default.
• W3120097089 hasConcept C185592680 @default.
• W3120097089 hasConcept C2777477808 @default.
• W3120097089 hasConcept C2777551382 @default.
• W3120097089 hasConcept C2777895019 @default.
• W3120097089 hasConcept C2778004101 @default.
• W3120097089 hasConcept C2778163477 @default.
• W3120097089 hasConcept C2779697368 @default.
• W3120097089 hasConcept C2780072125 @default.

• next