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• W3120107265 abstract "Urinary bladder is an organ which incessantly exposed to carcinogenic substances and may cause chronic inflammation may subsequently lead to tumorigenesis. The functional regulatory polymorphisms of TNF-α gene modulate its control of inflammation and other major functions that may eventually lead to tumorigenesis. To analyze the link between three genetic polymorphisms of TNF-α gene including −863C > A, −308 G > A and − 238 G > A and the risk of developing UBC in Indian population. Direct DNA sequencing method was performed for the assessment of genotyping of TNF-α gene polymorphisms in the blood samples of histopathologically confirmed 232 cases of UBC compared to cancer free 250 controls. We have conducted meta-analysis investigating the association between TNF-α −308 G > A polymorphism and the risk of UBC by using available data from six studies (including the present data), comprising 1397 cases and 1722 controls. Dominant model of −863C > A showed 2.33 fold higher risk of UBC in cases as compared to controls (p = 0.00003; OR = 2.33, 95%CI 1.56–3.47) while contrary, recessive model showed a significant protective effect (p = 0.03; OR = 0.45, 95%CI 0.23–0.91). Other polymorphism −238 G > A and − 308 G > A did not reveal significant association with UBC risk. Meta-analysis study did not show any significant association with the risk of UBC development (OR = 1.01, 95%CI 0.84–1.23; p = 0.88) with the fixed effect model (OR = 1.01, 95%CI 0.84–1.23; p = 0.88) random effect model. . Overall, the results suggest that TNF-α −863C > A polymorphism has been found to significantly influence the risk of UBC. Further researches are needed to understand its potential role on UBC risk." @default.
• W3120107265 created "2021-01-18" @default.
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• W3120107265 date "2021-02-01" @default.
• W3120107265 modified "2023-09-23" @default.
• W3120107265 title "TNF-α gene polymorphisms and risk of urinary bladder cancer – A case-control study and meta-analysis" @default.
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• W3120107265 doi "https://doi.org/10.1016/j.mgene.2020.100848" @default.
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