FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120136698> ?p ?o ?g. }

• W3120136698 abstract "Abstract Background A once-daily (o.d.) fixed-dose combination of indacaterol acetate (IND), glycopyrronium bromide (GLY), and mometasone furoate (MF) delivered via the Breezhaler ® device (IND/GLY/MF) is being developed for treatment of asthma. This study compared steady-state pharmacokinetics of IND, GLY and MF between Japanese and Caucasian male subjects after multiple inhalations of IND/GLY/MF o.d. Methods This was a single-center, open-label, 2-treatment crossover study with a 21-day washout period. Japanese and Caucasian subjects received IND/GLY/MF 150/50/80 μg (inhaled corticosteroid [ICS] medium-dose) or 150/50/160 μg o.d. (ICS high-dose) for 14 days in each period. Pharmacokinetics were characterized up to 24 h post-dose on Days 1 and 14. Results In total, 16 Japanese (median age 31 years [range 20–40 years], mean weight 68.3 kg) and 17 Caucasian subjects (median age 27 years [range 21–43 years], mean weight 75.0 kg) were randomized. Geometric mean ratios (Japanese/Caucasian) [90% confidence interval (CI)] for C max for IND, GLY and MF at the high ICS dose on Day 14 were 1.31 [1.13, 1.51] 1.38 [1.13, 1.69] and 1.07 [0.969, 1.18], respectively. Geometric mean ratios (Japanese/Caucasian) [90% CI] for AUC 0–24h on Day 14 for IND, GLY and MF at the high ICS dose were 1.17 [1.01, 1.35], 1.05 [0.920, 1.20] and 1.15 [1.05, 1.27] respectively. Similar trends were noted for all components for the medium ICS dose treatment. IND/GLY/MF was safe and well tolerated; no AEs suspected to be study drug-related were observed. Conclusion Pharmacokinetics of IND, GLY and MF (high and medium dose) when delivered as a fixed-dose combination were comparable between Japanese and Caucasian subjects. The IND/GLY/MF combination at the administrated doses was safe and well tolerated in both ethnic groups. Trial registration Japan Registry of Clinical Trial: jRCT2031200227, retrospectively registered on 04, December, 2020." @default.
• W3120136698 created "2021-01-18" @default.
• W3120136698 creator A5005948097 @default.
• W3120136698 creator A5012294278 @default.
• W3120136698 creator A5027654356 @default.
• W3120136698 creator A5029475937 @default.
• W3120136698 creator A5052062674 @default.
• W3120136698 creator A5074406503 @default.
• W3120136698 creator A5086307440 @default.
• W3120136698 date "2021-01-07" @default.
• W3120136698 modified "2023-10-10" @default.
• W3120136698 title "Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate administered as an inhaled fixed-dose combination in Japanese and Caucasian healthy subjects" @default.
• W3120136698 cites W1897953485 @default.
• W3120136698 cites W1957150943 @default.
• W3120136698 cites W1963602564 @default.
• W3120136698 cites W1990655430 @default.
• W3120136698 cites W1995867739 @default.
• W3120136698 cites W1997438133 @default.
• W3120136698 cites W1997934678 @default.
• W3120136698 cites W2003273340 @default.
• W3120136698 cites W2020662437 @default.
• W3120136698 cites W2021825189 @default.
• W3120136698 cites W2037286162 @default.
• W3120136698 cites W2042211250 @default.
• W3120136698 cites W2053351348 @default.
• W3120136698 cites W2055457865 @default.
• W3120136698 cites W2069984535 @default.
• W3120136698 cites W2085189889 @default.
• W3120136698 cites W2092589313 @default.
• W3120136698 cites W2110070028 @default.
• W3120136698 cites W2153034426 @default.
• W3120136698 cites W2253786685 @default.
• W3120136698 cites W2338558718 @default.
• W3120136698 cites W2529870379 @default.
• W3120136698 cites W2579315308 @default.
• W3120136698 cites W2586421425 @default.
• W3120136698 cites W2627065356 @default.
• W3120136698 cites W2797158782 @default.
• W3120136698 cites W3021086859 @default.
• W3120136698 cites W3041578668 @default.
• W3120136698 doi "https://doi.org/10.1186/s12890-020-01382-6" @default.
• W3120136698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7791651" @default.
• W3120136698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33413291" @default.
• W3120136698 hasPublicationYear "2021" @default.
• W3120136698 type Work @default.
• W3120136698 sameAs 3120136698 @default.
• W3120136698 citedByCount "5" @default.
• W3120136698 countsByYear W31201366982021 @default.
• W3120136698 countsByYear W31201366982023 @default.
• W3120136698 crossrefType "journal-article" @default.
• W3120136698 hasAuthorship W3120136698A5005948097 @default.
• W3120136698 hasAuthorship W3120136698A5012294278 @default.
• W3120136698 hasAuthorship W3120136698A5027654356 @default.
• W3120136698 hasAuthorship W3120136698A5029475937 @default.
• W3120136698 hasAuthorship W3120136698A5052062674 @default.
• W3120136698 hasAuthorship W3120136698A5074406503 @default.
• W3120136698 hasAuthorship W3120136698A5086307440 @default.
• W3120136698 hasBestOaLocation W31201366981 @default.
• W3120136698 hasConcept C105795698 @default.
• W3120136698 hasConcept C112705442 @default.
• W3120136698 hasConcept C126322002 @default.
• W3120136698 hasConcept C142724271 @default.
• W3120136698 hasConcept C204787440 @default.
• W3120136698 hasConcept C27081682 @default.
• W3120136698 hasConcept C2776042228 @default.
• W3120136698 hasConcept C2776804153 @default.
• W3120136698 hasConcept C2778884479 @default.
• W3120136698 hasConcept C2781018748 @default.
• W3120136698 hasConcept C2781348165 @default.
• W3120136698 hasConcept C33923547 @default.
• W3120136698 hasConcept C40222840 @default.
• W3120136698 hasConcept C42219234 @default.
• W3120136698 hasConcept C44249647 @default.
• W3120136698 hasConcept C71839028 @default.
• W3120136698 hasConcept C71924100 @default.
• W3120136698 hasConcept C87813604 @default.
• W3120136698 hasConcept C90924648 @default.
• W3120136698 hasConceptScore W3120136698C105795698 @default.
• W3120136698 hasConceptScore W3120136698C112705442 @default.
• W3120136698 hasConceptScore W3120136698C126322002 @default.
• W3120136698 hasConceptScore W3120136698C142724271 @default.
• W3120136698 hasConceptScore W3120136698C204787440 @default.
• W3120136698 hasConceptScore W3120136698C27081682 @default.
• W3120136698 hasConceptScore W3120136698C2776042228 @default.
• W3120136698 hasConceptScore W3120136698C2776804153 @default.
• W3120136698 hasConceptScore W3120136698C2778884479 @default.
• W3120136698 hasConceptScore W3120136698C2781018748 @default.
• W3120136698 hasConceptScore W3120136698C2781348165 @default.
• W3120136698 hasConceptScore W3120136698C33923547 @default.
• W3120136698 hasConceptScore W3120136698C40222840 @default.
• W3120136698 hasConceptScore W3120136698C42219234 @default.
• W3120136698 hasConceptScore W3120136698C44249647 @default.
• W3120136698 hasConceptScore W3120136698C71839028 @default.
• W3120136698 hasConceptScore W3120136698C71924100 @default.
• W3120136698 hasConceptScore W3120136698C87813604 @default.
• W3120136698 hasConceptScore W3120136698C90924648 @default.
• W3120136698 hasIssue "1" @default.
• W3120136698 hasLocation W31201366981 @default.
• W3120136698 hasLocation W31201366982 @default.
• W3120136698 hasLocation W31201366983 @default.

• next