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- W3120143504 endingPage "714" @default.
- W3120143504 startingPage "704" @default.
- W3120143504 abstract "Bacteriophages encode diverse anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas immunity during infection of their bacterial hosts. Although detailed mechanisms have been characterized for multiple Acr proteins, an understanding of their role in phage infection biology is just emerging. Here, we review recent work in this area and propose a framework of “phage autonomy” to evaluate CRISPR-immune evasion strategies. During phage infection, Acr proteins are deployed by a tightly regulated “fast on-fast off” transcriptional burst, which is necessary, but insufficient, for CRISPR-Cas inactivation. Instead of a single phage shutting down CRISPR-Cas immunity, a community of acr-carrying phages cooperate to suppress bacterial immunity, displaying low phage autonomy. Enzymatic Acr proteins with novel mechanisms have been recently revealed and are predicted to enhance phage autonomy, while phage DNA protective measures offer the highest phage autonomy observed. These varied Acr mechanisms and strengths also have unexpected impacts on the bacterial populations and competing phages." @default.
- W3120143504 created "2021-01-18" @default.
- W3120143504 creator A5027351735 @default.
- W3120143504 creator A5091580278 @default.
- W3120143504 date "2021-05-01" @default.
- W3120143504 modified "2023-09-26" @default.
- W3120143504 title "Anti-CRISPRs go viral: The infection biology of CRISPR-Cas inhibitors" @default.
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- W3120143504 doi "https://doi.org/10.1016/j.chom.2020.12.007" @default.
- W3120143504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8122014" @default.
- W3120143504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33444542" @default.
- W3120143504 hasPublicationYear "2021" @default.