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• W3120168130 abstract "To optimize and evaluate adiabatic pulses for pulsed arterial spin labeling at ultrahigh field 7 tesla.Four common adiabatic inversion pulses, including hyperbolic secant, wideband uniform rate smooth truncation, frequency offset corrected inversion, and time-resampled frequency offset corrected inversion pulses, were optimized based on a custom-defined loss function that included labeling efficiency and inversion band uniformity. The optimized pulses were implemented in flow-sensitive alternating inversion recovery sequences and tested on phantom and 11 healthy volunteers with 2 constraints: 1) specific absorption rate normalized; and 2) equal peak RF amplitude, respectively. A pseudo-continuous arterial spin labeling sequence was implemented for comparison. Quantitative metrics such as perfusion and relative labeling efficiency versus residual tissue signal were calculated.Among the 4 pulses, the wideband uniform rate smooth truncation pulse yielded the lowest loss in simulation and achieved a good balance between labeling efficiency and residual tissue signal from both phantom and in vivo experiments. Wideband uniform rate smooth truncation-pulsed arterial spin labeling showed significantly higher relative labeling efficiency compared to the other sequences (P < .01), whereas the perfusion signal was increased by 40% when the highest B1+ amplitude was used. The 4 pulsed arterial spin labeling sequences yielded comparable perfusion signals compared to pseudo-continuous arterial spin labeling but with less than half the specific absorption rate.Optimized wideband uniform rate smooth truncation pulse with the highest B1+ amplitude allowed was recommended for 7 tesla pulsed arterial spin labeling." @default.
• W3120168130 created "2021-01-18" @default.
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• W3120168130 date "2021-01-11" @default.
• W3120168130 modified "2023-10-16" @default.
• W3120168130 title "Optimization of adiabatic pulses for pulsed arterial spin labeling at 7 tesla: Comparison with pseudo‐continuous arterial spin labeling" @default.
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• W3120168130 doi "https://doi.org/10.1002/mrm.28661" @default.
• W3120168130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8351166" @default.
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