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- W3120168797 endingPage "2745" @default.
- W3120168797 startingPage "2727" @default.
- W3120168797 abstract "The increasing human population, combined with low inefficiency and adverse effects of available pesticides, has magnified the urgent need of developing next‐generation pesticides. Among the available approaches, strategies targeting invertebrate G protein‐coupled receptors (GPCRs) are very promising as these receptors are the targets of endogenous neuropeptides/neuromodulators that upon binding to their receptors induce profound changes in insect physiology. Therefore, exploring GPCR regulators has great potential in the development of targeted next‐generation pesticides. Despite the great potential of such alternative pesticides, so far there has been only one approved compound, Amitraz, which conveys its anti‐pest activity via the GPCR Octopamine receptor. Here, we review the current status of pesticide development, hazards associated with conventional pesticide compounds, alternative strategies that involve next‐generation of pesticides, structural features of GPCRs, and opportunities and challenges of targeting the members of this superfamily in invertebrates to develop anti‐pest agents. In conclusion, we emphasize that the potential of GPCRs cannot be utilized in full without more genomic and transcriptomic data to improve our understanding of the complex network of peptidergic signaling pathways. We argue how vital it is to obtain three‐dimensional (3D) structural data on physiologically important target GPCRs and encourage the readers to use the state of the art in silico methods such as virtual screening for the discovery of new pesticide compounds." @default.
- W3120168797 created "2021-01-18" @default.
- W3120168797 creator A5003381569 @default.
- W3120168797 creator A5016232826 @default.
- W3120168797 creator A5030451481 @default.
- W3120168797 creator A5054356120 @default.
- W3120168797 creator A5082627748 @default.
- W3120168797 date "2021-01-27" @default.
- W3120168797 modified "2023-10-16" @default.
- W3120168797 title "Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges" @default.
- W3120168797 cites W102481855 @default.
- W3120168797 cites W1533597609 @default.
- W3120168797 cites W1533971869 @default.
- W3120168797 cites W1664750859 @default.
- W3120168797 cites W1816638112 @default.
- W3120168797 cites W1845692052 @default.
- W3120168797 cites W1917955409 @default.
- W3120168797 cites W1963865415 @default.
- W3120168797 cites W1967461974 @default.
- W3120168797 cites W1969377006 @default.
- W3120168797 cites W1971666357 @default.
- W3120168797 cites W1973498157 @default.
- W3120168797 cites W1975708216 @default.
- W3120168797 cites W1976596942 @default.
- W3120168797 cites W1976667642 @default.
- W3120168797 cites W1979893222 @default.
- W3120168797 cites W1987703758 @default.
- W3120168797 cites W1990211184 @default.
- W3120168797 cites W1990798731 @default.
- W3120168797 cites W1994586595 @default.
- W3120168797 cites W1995018158 @default.
- W3120168797 cites W1995503870 @default.
- W3120168797 cites W1997384191 @default.
- W3120168797 cites W1999591184 @default.
- W3120168797 cites W1999772489 @default.
- W3120168797 cites W2000571686 @default.
- W3120168797 cites W2009356411 @default.
- W3120168797 cites W2012039718 @default.
- W3120168797 cites W2014923981 @default.
- W3120168797 cites W2015865718 @default.
- W3120168797 cites W2015945128 @default.
- W3120168797 cites W2016852829 @default.
- W3120168797 cites W2018685741 @default.
- W3120168797 cites W2019995399 @default.
- W3120168797 cites W2020168144 @default.
- W3120168797 cites W2021638966 @default.
- W3120168797 cites W2022341112 @default.
- W3120168797 cites W2028423171 @default.
- W3120168797 cites W2030319690 @default.
- W3120168797 cites W2030796378 @default.
- W3120168797 cites W2033829446 @default.
- W3120168797 cites W2035208962 @default.
- W3120168797 cites W2049128182 @default.
- W3120168797 cites W2050676639 @default.
- W3120168797 cites W2051660611 @default.
- W3120168797 cites W2064937529 @default.
- W3120168797 cites W2069268806 @default.
- W3120168797 cites W2069949257 @default.
- W3120168797 cites W2070114955 @default.
- W3120168797 cites W2070405413 @default.
- W3120168797 cites W2070787455 @default.
- W3120168797 cites W2070793709 @default.
- W3120168797 cites W2074840190 @default.
- W3120168797 cites W2082883714 @default.
- W3120168797 cites W2083689423 @default.
- W3120168797 cites W2083850113 @default.
- W3120168797 cites W2084839957 @default.
- W3120168797 cites W2086090539 @default.
- W3120168797 cites W2086631626 @default.
- W3120168797 cites W2087393229 @default.
- W3120168797 cites W2097233732 @default.
- W3120168797 cites W2098532466 @default.
- W3120168797 cites W2102246235 @default.
- W3120168797 cites W2103068682 @default.
- W3120168797 cites W2106658530 @default.
- W3120168797 cites W2106686513 @default.
- W3120168797 cites W2109014958 @default.
- W3120168797 cites W2119713789 @default.
- W3120168797 cites W2126512160 @default.
- W3120168797 cites W2129710424 @default.
- W3120168797 cites W2141813412 @default.
- W3120168797 cites W2149662691 @default.
- W3120168797 cites W2155331383 @default.
- W3120168797 cites W2157725915 @default.
- W3120168797 cites W2158809385 @default.
- W3120168797 cites W2159781759 @default.
- W3120168797 cites W2171158206 @default.
- W3120168797 cites W2192180610 @default.
- W3120168797 cites W2233201407 @default.
- W3120168797 cites W2317427843 @default.
- W3120168797 cites W2337029028 @default.
- W3120168797 cites W2339707255 @default.
- W3120168797 cites W2395691462 @default.
- W3120168797 cites W2407156775 @default.
- W3120168797 cites W2415088891 @default.
- W3120168797 cites W2509057624 @default.
- W3120168797 cites W2516773138 @default.
- W3120168797 cites W2561058767 @default.