Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120182331> ?p ?o ?g. }
- W3120182331 abstract "Abstract Diabetes mellitus (DM) exhibits a higher sensitivity to myocardial ischemia/reperfusion (I/R) injury and may compromise the effectiveness of cardioprotective interventions, including ischemic preconditioning. We previously found that liver ischemic preconditioning (RLIPC) could limit infarct size post I/R in non-diabetic rat hearts and further exerted anti-arrhythmic effects in diabetic or non-diabetic rats after myocardial I/R, however, little is known regarding the effect of RLIPC on infarct-sparing in diabetic hearts. In this study, we evaluated the protective effects of RLIPC on I/R injury in streptozotocin-induced type 1 diabetic rats. Type 1 diabetes mellitus was induced by one-time intraperitoneal injection of streptozotocin in Sprague–Dawley rats. Rats were exposed to 45 min of left anterior descend in (LAD) coronary artery occlusion, followed by 3 h of reperfusion. For liver ischemic preconditioning, four cycles of 5 min of liver I/R stimuli were performed before LAD occlusion. The cardioprotective effect of RLIPC was determined in diabetic rats. Compared to non-RLIPC treated DM rats, RLIPC treatment significantly reduced infarct size and cardiac tissue damage, inhibited apoptosis in diabetic hearts post I/R. RLIPC also improved cardiac functions including LVESP, LVEDP, dp/dtmax, and − dp/dtmax. In addition, RLIPC preserved cardiac morphology by reducing the pathological score post I/R in diabetic hearts. Finally, Westernblotting showed that RLIPC stimulated phosphorylation of ventricular GSK-3β and STAT-5, which are key components of RISK and SAFE signaling pathways. Our study showed that liver ischemic preconditioning retains strong cardioprotective properties in diabetic hearts against myocardial I/R injury via GSK-3β/STAT5 signaling pathway." @default.
- W3120182331 created "2021-01-18" @default.
- W3120182331 creator A5020512696 @default.
- W3120182331 creator A5044906743 @default.
- W3120182331 creator A5057422326 @default.
- W3120182331 creator A5081763167 @default.
- W3120182331 creator A5082365892 @default.
- W3120182331 creator A5083694367 @default.
- W3120182331 creator A5090031953 @default.
- W3120182331 date "2021-01-21" @default.
- W3120182331 modified "2023-10-12" @default.
- W3120182331 title "Remote liver ischemic preconditioning attenuates myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats" @default.
- W3120182331 cites W1558043083 @default.
- W3120182331 cites W1966924587 @default.
- W3120182331 cites W1967612089 @default.
- W3120182331 cites W1990140589 @default.
- W3120182331 cites W1991352341 @default.
- W3120182331 cites W1998694879 @default.
- W3120182331 cites W2006246868 @default.
- W3120182331 cites W2008880079 @default.
- W3120182331 cites W2012517632 @default.
- W3120182331 cites W2026313838 @default.
- W3120182331 cites W2030646361 @default.
- W3120182331 cites W2031466941 @default.
- W3120182331 cites W2040309436 @default.
- W3120182331 cites W2065679608 @default.
- W3120182331 cites W2072969092 @default.
- W3120182331 cites W2073596617 @default.
- W3120182331 cites W2082340666 @default.
- W3120182331 cites W2087931505 @default.
- W3120182331 cites W2096847688 @default.
- W3120182331 cites W2099374193 @default.
- W3120182331 cites W2122179672 @default.
- W3120182331 cites W2125369648 @default.
- W3120182331 cites W2142046694 @default.
- W3120182331 cites W2146217294 @default.
- W3120182331 cites W2147791296 @default.
- W3120182331 cites W2148233412 @default.
- W3120182331 cites W2158139135 @default.
- W3120182331 cites W2184029752 @default.
- W3120182331 cites W2210151709 @default.
- W3120182331 cites W2317629174 @default.
- W3120182331 cites W2537484745 @default.
- W3120182331 cites W2584875715 @default.
- W3120182331 cites W2608269806 @default.
- W3120182331 cites W2746525012 @default.
- W3120182331 cites W2770124268 @default.
- W3120182331 cites W2804017959 @default.
- W3120182331 cites W2912377300 @default.
- W3120182331 cites W3010045746 @default.
- W3120182331 doi "https://doi.org/10.1038/s41598-021-81422-1" @default.
- W3120182331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7820418" @default.
- W3120182331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33479330" @default.
- W3120182331 hasPublicationYear "2021" @default.
- W3120182331 type Work @default.
- W3120182331 sameAs 3120182331 @default.
- W3120182331 citedByCount "9" @default.
- W3120182331 countsByYear W31201823312021 @default.
- W3120182331 countsByYear W31201823312022 @default.
- W3120182331 countsByYear W31201823312023 @default.
- W3120182331 crossrefType "journal-article" @default.
- W3120182331 hasAuthorship W3120182331A5020512696 @default.
- W3120182331 hasAuthorship W3120182331A5044906743 @default.
- W3120182331 hasAuthorship W3120182331A5057422326 @default.
- W3120182331 hasAuthorship W3120182331A5081763167 @default.
- W3120182331 hasAuthorship W3120182331A5082365892 @default.
- W3120182331 hasAuthorship W3120182331A5083694367 @default.
- W3120182331 hasAuthorship W3120182331A5090031953 @default.
- W3120182331 hasBestOaLocation W31201823311 @default.
- W3120182331 hasConcept C126322002 @default.
- W3120182331 hasConcept C134018914 @default.
- W3120182331 hasConcept C164705383 @default.
- W3120182331 hasConcept C178853913 @default.
- W3120182331 hasConcept C2776820930 @default.
- W3120182331 hasConcept C2779280383 @default.
- W3120182331 hasConcept C2779311647 @default.
- W3120182331 hasConcept C2780114680 @default.
- W3120182331 hasConcept C2780159080 @default.
- W3120182331 hasConcept C48277249 @default.
- W3120182331 hasConcept C500558357 @default.
- W3120182331 hasConcept C541997718 @default.
- W3120182331 hasConcept C555293320 @default.
- W3120182331 hasConcept C71924100 @default.
- W3120182331 hasConceptScore W3120182331C126322002 @default.
- W3120182331 hasConceptScore W3120182331C134018914 @default.
- W3120182331 hasConceptScore W3120182331C164705383 @default.
- W3120182331 hasConceptScore W3120182331C178853913 @default.
- W3120182331 hasConceptScore W3120182331C2776820930 @default.
- W3120182331 hasConceptScore W3120182331C2779280383 @default.
- W3120182331 hasConceptScore W3120182331C2779311647 @default.
- W3120182331 hasConceptScore W3120182331C2780114680 @default.
- W3120182331 hasConceptScore W3120182331C2780159080 @default.
- W3120182331 hasConceptScore W3120182331C48277249 @default.
- W3120182331 hasConceptScore W3120182331C500558357 @default.
- W3120182331 hasConceptScore W3120182331C541997718 @default.
- W3120182331 hasConceptScore W3120182331C555293320 @default.
- W3120182331 hasConceptScore W3120182331C71924100 @default.
- W3120182331 hasFunder F4320321001 @default.
- W3120182331 hasFunder F4320336042 @default.
- W3120182331 hasIssue "1" @default.