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- W3120191736 abstract "Abstract Background: To assess the efficacy of combined external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT) with Cf-252 neutrons versus Ir-192 photons in matched pairs for stage IIB adenocarcinoma of the uterine cervix (AC). Methods: Patients with stage IIB AC were matched into 19 pairs between January 2005 and March 2013 and were divided into neutron ICBT (NICBT) and photon ICBT (PICBT) groups. Pelvic EBRT was administered with 2 Gy/fraction, 4 fractions/week, to a total dose of 50–54 Gy, with the center of pelvic field blocked by 4 cm in width after 20–36 Gy in both groups. NICBT and PICBT were administered with 10.5–13 Gy-eq/fraction vs. 10–13 Gy/fraction, to a total dose of 42–53.2 Gy-eq vs. 40–51 Gy at point A. Radiotherapy was administered concurrently and sequentially with 2–4 cycles of chemotherapy, consisting of cisplatin, or carboplatin, and paclitaxel only in PICBT groups. Survival data and late complication rates were assessed using the Kaplan-Meier method, log rank, t test, and 2 × 2 contingency analysis. Results: The 5-year OS and DFS rate in the NICBT group were significantly higher than those of the PICBT group. Early treatment toxicity and late complications were mild in both groups. Conclusion: The combination of EBRT and Cf-252 neutron ICBT alone is more effective than the combination of EBRT and Ir-192 photon ICBT with concurrent and sequential chemotherapy for stage IIB AC patients." @default.
- W3120191736 created "2021-01-18" @default.
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- W3120191736 date "2020-08-05" @default.
- W3120191736 modified "2023-10-03" @default.
- W3120191736 title "The Combination of External Beam Radiotherapy with Cf (Californium)-252 Neutron Intracavitary Brachytherapy is Significantly Effective than with Ir (Iridium)-192 Gamma Intracavitary Brachytherapy in Controlling Stage IIB Cervical Adenocarcinoma: A Matched Pair Analysis" @default.
- W3120191736 doi "https://doi.org/10.21203/rs.3.rs-51045/v1" @default.
- W3120191736 hasPublicationYear "2020" @default.
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