FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120193952> ?p ?o ?g. }

• W3120193952 abstract "Abstract It remains unclear how hepatic steatosis links to inflammation. Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that senses fat in the liver and is upregulated prior to weight gain. The aim of this study was to investigate the significance of LECT2 in the development of nonalcoholic steatohepatitis (NASH). In human liver biopsy samples, elevated LECT2 mRNA levels were positively correlated with body mass index (BMI) and increased in patients who have steatosis and inflammation in the liver. LECT2 mRNA levels were also positively correlated with the mRNA levels of the inflammatory genes CCR2 and TLR4 . In C57BL/6J mice fed with a high-fat diet, mRNA levels of the inflammatory cytokines Tnfa and Nos2 were significantly lower in Lect2 KO mice. In flow cytometry analyses, the number of M1-like macrophages and M1/M2 ratio were significantly lower in Lect2 KO mice than in WT mice. In KUP5, mouse kupffer cell line , LECT2 selectively enhanced the LPS-induced phosphorylation of JNK, but not that of ERK and p38. Consistently, LECT2 enhanced the LPS-induced phosphorylation of MKK4 and TAB2, upstream activators of JNK. Hepatic expression of LECT2 is upregulated in association with the inflammatory signature in human liver tissues. The elevation of LECT2 shifts liver residual macrophage to the M1-like phenotype, and contributes to the development of liver inflammation. These findings shed light on the hepatokine LECT2 as a potential therapeutic target that can dissociate liver steatosis from inflammation." @default.
• W3120193952 created "2021-01-18" @default.
• W3120193952 creator A5009165742 @default.
• W3120193952 creator A5013160788 @default.
• W3120193952 creator A5017380559 @default.
• W3120193952 creator A5026569502 @default.
• W3120193952 creator A5040374875 @default.
• W3120193952 creator A5040946156 @default.
• W3120193952 creator A5046506553 @default.
• W3120193952 creator A5055368292 @default.
• W3120193952 creator A5059485526 @default.
• W3120193952 creator A5061012817 @default.
• W3120193952 creator A5069065380 @default.
• W3120193952 creator A5082644268 @default.
• W3120193952 creator A5085385311 @default.
• W3120193952 creator A5088365918 @default.
• W3120193952 creator A5089497139 @default.
• W3120193952 creator A5090254767 @default.
• W3120193952 date "2021-01-12" @default.
• W3120193952 modified "2023-09-30" @default.
• W3120193952 title "LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH" @default.
• W3120193952 cites W1196553794 @default.
• W3120193952 cites W1606389306 @default.
• W3120193952 cites W1967218150 @default.
• W3120193952 cites W1967972402 @default.
• W3120193952 cites W1980376777 @default.
• W3120193952 cites W1992366656 @default.
• W3120193952 cites W2000243096 @default.
• W3120193952 cites W2007078899 @default.
• W3120193952 cites W2020834752 @default.
• W3120193952 cites W2028320377 @default.
• W3120193952 cites W2030456544 @default.
• W3120193952 cites W2038018821 @default.
• W3120193952 cites W2042694297 @default.
• W3120193952 cites W2052041349 @default.
• W3120193952 cites W2074936957 @default.
• W3120193952 cites W2091648681 @default.
• W3120193952 cites W2093222101 @default.
• W3120193952 cites W2094884053 @default.
• W3120193952 cites W2123907958 @default.
• W3120193952 cites W2129882807 @default.
• W3120193952 cites W2145697808 @default.
• W3120193952 cites W2146042209 @default.
• W3120193952 cites W2165318249 @default.
• W3120193952 cites W2172053085 @default.
• W3120193952 cites W2508544196 @default.
• W3120193952 cites W2734724639 @default.
• W3120193952 cites W2970419481 @default.
• W3120193952 cites W2992734068 @default.
• W3120193952 cites W3046925854 @default.
• W3120193952 doi "https://doi.org/10.1038/s41598-020-80689-0" @default.
• W3120193952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7804418" @default.
• W3120193952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33436955" @default.
• W3120193952 hasPublicationYear "2021" @default.
• W3120193952 type Work @default.
• W3120193952 sameAs 3120193952 @default.
• W3120193952 citedByCount "27" @default.
• W3120193952 countsByYear W31201939522021 @default.
• W3120193952 countsByYear W31201939522022 @default.
• W3120193952 countsByYear W31201939522023 @default.
• W3120193952 crossrefType "journal-article" @default.
• W3120193952 hasAuthorship W3120193952A5009165742 @default.
• W3120193952 hasAuthorship W3120193952A5013160788 @default.
• W3120193952 hasAuthorship W3120193952A5017380559 @default.
• W3120193952 hasAuthorship W3120193952A5026569502 @default.
• W3120193952 hasAuthorship W3120193952A5040374875 @default.
• W3120193952 hasAuthorship W3120193952A5040946156 @default.
• W3120193952 hasAuthorship W3120193952A5046506553 @default.
• W3120193952 hasAuthorship W3120193952A5055368292 @default.
• W3120193952 hasAuthorship W3120193952A5059485526 @default.
• W3120193952 hasAuthorship W3120193952A5061012817 @default.
• W3120193952 hasAuthorship W3120193952A5069065380 @default.
• W3120193952 hasAuthorship W3120193952A5082644268 @default.
• W3120193952 hasAuthorship W3120193952A5085385311 @default.
• W3120193952 hasAuthorship W3120193952A5088365918 @default.
• W3120193952 hasAuthorship W3120193952A5089497139 @default.
• W3120193952 hasAuthorship W3120193952A5090254767 @default.
• W3120193952 hasBestOaLocation W31201939521 @default.
• W3120193952 hasConcept C104317684 @default.
• W3120193952 hasConcept C126322002 @default.
• W3120193952 hasConcept C127561419 @default.
• W3120193952 hasConcept C134018914 @default.
• W3120193952 hasConcept C17991360 @default.
• W3120193952 hasConcept C2776175330 @default.
• W3120193952 hasConcept C2776914184 @default.
• W3120193952 hasConcept C2778772119 @default.
• W3120193952 hasConcept C2779134260 @default.
• W3120193952 hasConcept C2779478299 @default.
• W3120193952 hasConcept C2780559512 @default.
• W3120193952 hasConcept C55493867 @default.
• W3120193952 hasConcept C71924100 @default.
• W3120193952 hasConcept C86803240 @default.
• W3120193952 hasConceptScore W3120193952C104317684 @default.
• W3120193952 hasConceptScore W3120193952C126322002 @default.
• W3120193952 hasConceptScore W3120193952C127561419 @default.
• W3120193952 hasConceptScore W3120193952C134018914 @default.
• W3120193952 hasConceptScore W3120193952C17991360 @default.
• W3120193952 hasConceptScore W3120193952C2776175330 @default.
• W3120193952 hasConceptScore W3120193952C2776914184 @default.
• W3120193952 hasConceptScore W3120193952C2778772119 @default.

• next