Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120197372> ?p ?o ?g. }
- W3120197372 abstract "Persistence has evolved as a potent survival strategy to overcome adverse environmental conditions. This capability is common to almost all bacteria, including all human bacterial pathogens and likely connected to chronic infections caused by some of these pathogens. Although the majority of a bacterial cell population will be killed by the particular stressors, like antibiotics, oxygen and nitrogen radicals, nutrient starvation and others, a varying subpopulation (termed persisters) will withstand the stress situation and will be able to revive once the stress is removed. Several factors and pathways have been identified in the past that apparently favor the formation of persistence, such as various toxin/antitoxin modules or stringent response together with the alarmone (p)ppGpp. However, persistence can occur stochastically in few cells even of stress-free bacterial populations. Growth of these cells could then be induced by the stress conditions. In this review, we focus on the persister formation of human intracellular bacterial pathogens, some of which belong to the most successful persister producers but lack some or even all of the assumed persistence-triggering factors and pathways. We propose a mechanism for the persister formation of these bacterial pathogens which is based on their specific intracellular bipartite metabolism. We postulate that this mode of metabolism ultimately leads, under certain starvation conditions, to the stalling of DNA replication initiation which may be causative for the persister state." @default.
- W3120197372 created "2021-01-18" @default.
- W3120197372 creator A5019230382 @default.
- W3120197372 creator A5025017281 @default.
- W3120197372 creator A5061433515 @default.
- W3120197372 creator A5086504004 @default.
- W3120197372 date "2021-01-14" @default.
- W3120197372 modified "2023-10-17" @default.
- W3120197372 title "Persistence of Intracellular Bacterial Pathogens—With a Focus on the Metabolic Perspective" @default.
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