Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120223850> ?p ?o ?g. }
- W3120223850 abstract "SUMMARY The natural killer (NK) and non-cytotoxic innate lymphoid cells (ILC) lineages play vital role in the regulation of the immune system. Yet understanding of mechanisms controlling NK/ILC development remains incomplete. The evolutionary conserved FOXO family of forkhead transcription factors are critical regulators of cellular processes. We found that the loss of FOXO1 and FOXO3 together caused impaired activation of the NK gene expression program and reduced ETS binding already at the common lymphoid progenitor (CLP) level and a block at the ILC progenitor (ILCP) to NK progenitor transition. FOXO controlled NK cell maturation in organ specific manner and their ability to respond to IL-15. At the ILCP level, disruption of the ILC lineage specific gene programs was associated with broad perturbation of the generation of the non-cytotoxic ILC subsets. We concluded that FOXO1 and FOXO3 cooperatively regulate ILC lineage specification at the progenitor level as well as the generation of mature ILCs." @default.
- W3120223850 created "2021-01-18" @default.
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- W3120223850 date "2021-01-14" @default.
- W3120223850 modified "2023-09-30" @default.
- W3120223850 title "FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development" @default.
- W3120223850 cites W1544691147 @default.
- W3120223850 cites W1561070512 @default.
- W3120223850 cites W1652264402 @default.
- W3120223850 cites W1920308589 @default.
- W3120223850 cites W1971617105 @default.
- W3120223850 cites W1976026025 @default.
- W3120223850 cites W1977627324 @default.
- W3120223850 cites W2002307060 @default.
- W3120223850 cites W2002483968 @default.
- W3120223850 cites W2002817805 @default.
- W3120223850 cites W2006178861 @default.
- W3120223850 cites W2027643215 @default.
- W3120223850 cites W2028091596 @default.
- W3120223850 cites W2030375564 @default.
- W3120223850 cites W2032163135 @default.
- W3120223850 cites W2033223710 @default.
- W3120223850 cites W2038988941 @default.
- W3120223850 cites W2044723012 @default.
- W3120223850 cites W2046271789 @default.
- W3120223850 cites W2046834785 @default.
- W3120223850 cites W2057781689 @default.
- W3120223850 cites W2062618476 @default.
- W3120223850 cites W2062629127 @default.
- W3120223850 cites W2063261544 @default.
- W3120223850 cites W2065201368 @default.
- W3120223850 cites W2070745300 @default.
- W3120223850 cites W2077907997 @default.
- W3120223850 cites W2080196128 @default.
- W3120223850 cites W2080781820 @default.
- W3120223850 cites W2083554435 @default.
- W3120223850 cites W2085052707 @default.
- W3120223850 cites W2087580642 @default.
- W3120223850 cites W2089500151 @default.
- W3120223850 cites W2096449627 @default.
- W3120223850 cites W2098845312 @default.
- W3120223850 cites W2100244924 @default.
- W3120223850 cites W2103265231 @default.
- W3120223850 cites W2109877208 @default.
- W3120223850 cites W2110503722 @default.
- W3120223850 cites W2112926547 @default.
- W3120223850 cites W2114104545 @default.
- W3120223850 cites W2122511635 @default.
- W3120223850 cites W2124261225 @default.
- W3120223850 cites W2124645233 @default.
- W3120223850 cites W2131167502 @default.
- W3120223850 cites W2134199670 @default.
- W3120223850 cites W2137035181 @default.
- W3120223850 cites W2137810424 @default.
- W3120223850 cites W2142285575 @default.
- W3120223850 cites W2149011343 @default.
- W3120223850 cites W2156563694 @default.
- W3120223850 cites W2161659436 @default.
- W3120223850 cites W2167035168 @default.
- W3120223850 cites W2167150291 @default.
- W3120223850 cites W2171907652 @default.
- W3120223850 cites W2235808789 @default.
- W3120223850 cites W2247766769 @default.
- W3120223850 cites W2308713192 @default.
- W3120223850 cites W2331547930 @default.
- W3120223850 cites W2557552196 @default.
- W3120223850 cites W2565466068 @default.
- W3120223850 cites W2572193671 @default.
- W3120223850 cites W2587933500 @default.
- W3120223850 cites W2599330610 @default.
- W3120223850 cites W2605742670 @default.
- W3120223850 cites W2625483683 @default.
- W3120223850 cites W2736920842 @default.
- W3120223850 cites W2744632602 @default.
- W3120223850 cites W2791193037 @default.
- W3120223850 cites W2923917116 @default.
- W3120223850 cites W2944209771 @default.
- W3120223850 cites W2944276385 @default.
- W3120223850 cites W2946500233 @default.
- W3120223850 cites W2952034057 @default.
- W3120223850 cites W2987931162 @default.
- W3120223850 cites W3006483160 @default.