Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120226075> ?p ?o ?g. }
- W3120226075 abstract "The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial and phenotypic immune-ITH from multiple tumour sectors and decipher its relationship with tumour evolution and disease progression in hepatocellular carcinomas (HCC). Immune-ITH is associated with tumour transcriptomic-ITH, mutational burden and distinct immune microenvironments. Tumours with low immune-ITH experience higher immunoselective pressure and escape via loss of heterozygosity in human leukocyte antigens and immunoediting. Instead, the tumours with high immune-ITH evolve to a more immunosuppressive/exhausted microenvironment. This gradient of immune pressure along with immune-ITH represents a hallmark of tumour evolution, which is closely linked to the transcriptome-immune networks contributing to disease progression and immune inactivation. Remarkably, high immune-ITH and its transcriptomic signature are predictive for worse clinical outcome in HCC patients. This in-depth investigation of ITH provides evidence on tumour-immune co-evolution along HCC progression." @default.
- W3120226075 created "2021-01-18" @default.
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- W3120226075 date "2021-01-11" @default.
- W3120226075 modified "2023-10-16" @default.
- W3120226075 title "Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma" @default.
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- W3120226075 doi "https://doi.org/10.1038/s41467-020-20171-7" @default.
- W3120226075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7801667" @default.
- W3120226075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33431814" @default.
- W3120226075 hasPublicationYear "2021" @default.