Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120226321> ?p ?o ?g. }
- W3120226321 endingPage "118966" @default.
- W3120226321 startingPage "118966" @default.
- W3120226321 abstract "Activation of the Wnt/β-catenin pathway is one of the hallmarks of colorectal cancer (CRC). Sirtuin 2 (SIRT2) protein has been shown to inhibit CRC proliferation. Previously, we reported that SIRT2 plays an important role in the maintenance of normal intestinal cell homeostasis. Here, we show that SIRT2 is a direct target gene of Wnt/β-catenin signaling in CRC cells. Inhibition or knockdown of Wnt/β-catenin increased SIRT2 promoter activity and mRNA and protein expression, whereas activation of Wnt/β-catenin decreased SIRT2 promoter activity and expression. β-Catenin was recruited to the promoter of SIRT2 and transcriptionally regulated SIRT2 expression. Wnt/β-catenin inhibition increased mitochondrial oxidative phosphorylation (OXPHOS) and CRC cell differentiation. Moreover, inhibition of OXPHOS attenuated the differentiation of CRC cells induced by Wnt/β-catenin inhibition. In contrast, inhibition or knockdown of SIRT2 decreased, while overexpression of SIRT2 increased, OXPHOS activity and differentiation in CRC cells. Consistently, inhibition or knockdown or SIRT2 attenuated the differentiation induced by Wnt/β-catenin inhibition. These results demonstrate that SIRT2 is a novel target gene of the Wnt/β-catenin signaling and contributes to the differentiation of CRC cells." @default.
- W3120226321 created "2021-01-18" @default.
- W3120226321 creator A5020109340 @default.
- W3120226321 creator A5023436882 @default.
- W3120226321 creator A5028761394 @default.
- W3120226321 creator A5031721512 @default.
- W3120226321 creator A5033473169 @default.
- W3120226321 creator A5049763932 @default.
- W3120226321 creator A5066347342 @default.
- W3120226321 creator A5069334991 @default.
- W3120226321 date "2021-04-01" @default.
- W3120226321 modified "2023-09-27" @default.
- W3120226321 title "Regulation of SIRT2 by Wnt/β-catenin signaling pathway in colorectal cancer cells" @default.
- W3120226321 cites W1596536997 @default.
- W3120226321 cites W1619283040 @default.
- W3120226321 cites W1655178001 @default.
- W3120226321 cites W1848671119 @default.
- W3120226321 cites W1942026987 @default.
- W3120226321 cites W1974906186 @default.
- W3120226321 cites W1983712244 @default.
- W3120226321 cites W1988756509 @default.
- W3120226321 cites W1992379971 @default.
- W3120226321 cites W1998974491 @default.
- W3120226321 cites W2001804808 @default.
- W3120226321 cites W2020531899 @default.
- W3120226321 cites W2027843251 @default.
- W3120226321 cites W2040462263 @default.
- W3120226321 cites W2066852267 @default.
- W3120226321 cites W2073848428 @default.
- W3120226321 cites W2076852872 @default.
- W3120226321 cites W2085961304 @default.
- W3120226321 cites W2102755534 @default.
- W3120226321 cites W2107648723 @default.
- W3120226321 cites W2120269934 @default.
- W3120226321 cites W2129201068 @default.
- W3120226321 cites W2134920945 @default.
- W3120226321 cites W2148682389 @default.
- W3120226321 cites W2161080156 @default.
- W3120226321 cites W2163169815 @default.
- W3120226321 cites W2163294242 @default.
- W3120226321 cites W2229381260 @default.
- W3120226321 cites W231220508 @default.
- W3120226321 cites W2559869600 @default.
- W3120226321 cites W2577222535 @default.
- W3120226321 cites W2578248437 @default.
- W3120226321 cites W2593870963 @default.
- W3120226321 cites W2594543006 @default.
- W3120226321 cites W2608681872 @default.
- W3120226321 cites W2621361823 @default.
- W3120226321 cites W2792873661 @default.
- W3120226321 cites W2794126345 @default.
- W3120226321 cites W2799537874 @default.
- W3120226321 cites W2885533763 @default.
- W3120226321 cites W2886638087 @default.
- W3120226321 cites W2899721933 @default.
- W3120226321 cites W2901590424 @default.
- W3120226321 cites W2911084679 @default.
- W3120226321 cites W2925333382 @default.
- W3120226321 cites W2971498403 @default.
- W3120226321 cites W2973255467 @default.
- W3120226321 cites W2982858973 @default.
- W3120226321 cites W2989425431 @default.
- W3120226321 cites W2995898384 @default.
- W3120226321 cites W3000620951 @default.
- W3120226321 cites W3005474817 @default.
- W3120226321 cites W3010018355 @default.
- W3120226321 cites W3012977754 @default.
- W3120226321 cites W3017979273 @default.
- W3120226321 cites W3193956046 @default.
- W3120226321 cites W4211173018 @default.
- W3120226321 cites W842094027 @default.
- W3120226321 doi "https://doi.org/10.1016/j.bbamcr.2021.118966" @default.
- W3120226321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7939112" @default.
- W3120226321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33450304" @default.
- W3120226321 hasPublicationYear "2021" @default.
- W3120226321 type Work @default.
- W3120226321 sameAs 3120226321 @default.
- W3120226321 citedByCount "12" @default.
- W3120226321 countsByYear W31202263212022 @default.
- W3120226321 countsByYear W31202263212023 @default.
- W3120226321 crossrefType "journal-article" @default.
- W3120226321 hasAuthorship W3120226321A5020109340 @default.
- W3120226321 hasAuthorship W3120226321A5023436882 @default.
- W3120226321 hasAuthorship W3120226321A5028761394 @default.
- W3120226321 hasAuthorship W3120226321A5031721512 @default.
- W3120226321 hasAuthorship W3120226321A5033473169 @default.
- W3120226321 hasAuthorship W3120226321A5049763932 @default.
- W3120226321 hasAuthorship W3120226321A5066347342 @default.
- W3120226321 hasAuthorship W3120226321A5069334991 @default.
- W3120226321 hasBestOaLocation W31202263211 @default.
- W3120226321 hasConcept C104317684 @default.
- W3120226321 hasConcept C119157956 @default.
- W3120226321 hasConcept C137620995 @default.
- W3120226321 hasConcept C173396325 @default.
- W3120226321 hasConcept C185592680 @default.
- W3120226321 hasConcept C199848840 @default.
- W3120226321 hasConcept C2779324961 @default.
- W3120226321 hasConcept C2780561631 @default.