Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120230403> ?p ?o ?g. }
- W3120230403 abstract "The dentate granule cells (DGCs) play a crucial role in learning and memory. Many studies have described the role and physiological properties of these sparsely active neurons using different behavioral contexts. However, the morpho-functional features of DGCs recruited in mice maintained in their home cage (without training), considered as a baseline condition, have not yet been established. Using fosGFP transgenic mice, we observed ex vivo that DGCs recruited in animals maintained in the home cage condition are mature neurons that display a longer dendritic tree and lower excitability compared with non-activated cells. The higher GABA A receptor-mediated shunting inhibition contributes to the lower excitability of DGCs activated in the home environment by shifting the input resistance towards lower values. Remarkably, that shunting inhibition is neither observed in non-activated DGCs nor in DGCs activated during training in virtual reality. In short, our results suggest that strong shunting inhibition and reduced excitability could constitute a distinctive neural signature of mature DGCs recruited in the context of the home environment." @default.
- W3120230403 created "2021-01-18" @default.
- W3120230403 creator A5012500628 @default.
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- W3120230403 creator A5091914077 @default.
- W3120230403 creator A5009212392 @default.
- W3120230403 date "2021-01-15" @default.
- W3120230403 modified "2023-10-18" @default.
- W3120230403 title "Dentate Granule Cells Recruited in the Home Environment Display Distinctive Properties" @default.
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