Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120244889> ?p ?o ?g. }
- W3120244889 endingPage "269" @default.
- W3120244889 startingPage "257" @default.
- W3120244889 abstract "C-Src kinase is localized in several subcellular compartments, including mitochondria where it is involved in the regulation of organelle functions and overall metabolism. Surprisingly, the characterization of the intramitochondrial Src interactome has never been fully determined. Using in vitro proximity-dependent biotin identification (BioID) coupled to mass spectrometry, we identified 51 candidate proteins that may interact directly or indirectly with c-Src within the mitochondrial matrix. Pathway analysis suggests that these proteins are involved in a large array of mitochondrial functions such as protein folding and import, mitochondrial organization and transport, oxidative phosphorylation, tricarboxylic acid cycle and metabolism of amino and fatty acids. Among these proteins, we identified 24 tyrosine phosphorylation sites in 17 mitochondrial proteins (AKAP1, VDAC1, VDAC2, VDAC3, LonP1, Hsp90, SLP2, PHB2, MIC60, UBA1, EF-Tu, LRPPRC, ACO2, OAT, ACAT1, ETFβ and ATP5β) as potential substrates for intramitochondrial Src using in silico prediction of tyrosine phospho-sites. Interaction of c-Src with SLP2 and ATP5β was confirmed using coimmunoprecipitation. This study suggests that the intramitochondrial Src could target several proteins and regulate different mitochondrial functions." @default.
- W3120244889 created "2021-01-18" @default.
- W3120244889 creator A5040364555 @default.
- W3120244889 creator A5070307231 @default.
- W3120244889 creator A5087173672 @default.
- W3120244889 creator A5090415863 @default.
- W3120244889 date "2021-03-01" @default.
- W3120244889 modified "2023-10-16" @default.
- W3120244889 title "Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification" @default.
- W3120244889 cites W1107208185 @default.
- W3120244889 cites W1198120054 @default.
- W3120244889 cites W1583700542 @default.
- W3120244889 cites W1970264613 @default.
- W3120244889 cites W1973965384 @default.
- W3120244889 cites W1980372975 @default.
- W3120244889 cites W1984695384 @default.
- W3120244889 cites W1987641148 @default.
- W3120244889 cites W1990915902 @default.
- W3120244889 cites W1993052628 @default.
- W3120244889 cites W2000535878 @default.
- W3120244889 cites W2005255392 @default.
- W3120244889 cites W2007674710 @default.
- W3120244889 cites W2010678713 @default.
- W3120244889 cites W2019938661 @default.
- W3120244889 cites W2024161072 @default.
- W3120244889 cites W2024233959 @default.
- W3120244889 cites W2024236896 @default.
- W3120244889 cites W2026279585 @default.
- W3120244889 cites W2026406389 @default.
- W3120244889 cites W2028135614 @default.
- W3120244889 cites W2032116260 @default.
- W3120244889 cites W2032157282 @default.
- W3120244889 cites W2036988959 @default.
- W3120244889 cites W2053656371 @default.
- W3120244889 cites W2058597692 @default.
- W3120244889 cites W2060552645 @default.
- W3120244889 cites W2061271609 @default.
- W3120244889 cites W2061912939 @default.
- W3120244889 cites W2062488759 @default.
- W3120244889 cites W2064080426 @default.
- W3120244889 cites W2065632930 @default.
- W3120244889 cites W2071644881 @default.
- W3120244889 cites W2072371514 @default.
- W3120244889 cites W2079139546 @default.
- W3120244889 cites W2084688946 @default.
- W3120244889 cites W2086578843 @default.
- W3120244889 cites W2091787667 @default.
- W3120244889 cites W2094143445 @default.
- W3120244889 cites W2095368496 @default.
- W3120244889 cites W2097840941 @default.
- W3120244889 cites W2102756292 @default.
- W3120244889 cites W2105707485 @default.
- W3120244889 cites W2108560778 @default.
- W3120244889 cites W2122003003 @default.
- W3120244889 cites W2122395913 @default.
- W3120244889 cites W2124607936 @default.
- W3120244889 cites W2129004089 @default.
- W3120244889 cites W2129077074 @default.
- W3120244889 cites W2130106722 @default.
- W3120244889 cites W2133029725 @default.
- W3120244889 cites W2146578030 @default.
- W3120244889 cites W2147036305 @default.
- W3120244889 cites W2150419742 @default.
- W3120244889 cites W2166886529 @default.
- W3120244889 cites W2168310850 @default.
- W3120244889 cites W2170282641 @default.
- W3120244889 cites W2259282515 @default.
- W3120244889 cites W2291970866 @default.
- W3120244889 cites W2304846645 @default.
- W3120244889 cites W2342459683 @default.
- W3120244889 cites W2409675208 @default.
- W3120244889 cites W2461183258 @default.
- W3120244889 cites W2549945904 @default.
- W3120244889 cites W2562998505 @default.
- W3120244889 cites W2589623897 @default.
- W3120244889 cites W2784128526 @default.
- W3120244889 cites W2791913107 @default.
- W3120244889 cites W2887345219 @default.
- W3120244889 cites W2901129660 @default.
- W3120244889 cites W2905933048 @default.
- W3120244889 cites W2907194652 @default.
- W3120244889 cites W2971418655 @default.
- W3120244889 cites W2971840884 @default.
- W3120244889 cites W2991231224 @default.
- W3120244889 cites W2992856652 @default.
- W3120244889 cites W3010827019 @default.
- W3120244889 cites W3014006730 @default.
- W3120244889 cites W3014471733 @default.
- W3120244889 cites W3026084821 @default.
- W3120244889 cites W4246631357 @default.
- W3120244889 doi "https://doi.org/10.1016/j.mito.2020.12.012" @default.
- W3120244889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33412331" @default.
- W3120244889 hasPublicationYear "2021" @default.
- W3120244889 type Work @default.
- W3120244889 sameAs 3120244889 @default.
- W3120244889 citedByCount "7" @default.
- W3120244889 countsByYear W31202448892022 @default.
- W3120244889 countsByYear W31202448892023 @default.