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- W3120276766 abstract "Abstract Electrical stimulation of the mammalian efferent vestibular system (EVS) predominantly excites primary vestibular afferents along two distinct time scales. Although roles for acetylcholine (ACh) have been demonstrated in other vertebrates, synaptic mechanisms underlying mammalian EVS actions are not well-characterized. To determine if activation of ACh receptors account for efferent-mediated afferent excitation in mammals, we recorded afferent activity from the superior vestibular nerve of anesthetized C57BL/6 mice while stimulating EVS neurons in the brainstem, before and after administration of cholinergic antagonists. Using a normalized coefficient of variation (CV*), we broadly classified vestibular afferents as regularly- (CV* < 0.1) or irregularly-discharging (CV* > 0.1) and characterized their responses to midline or ipsilateral EVS stimulation. Afferent responses to efferent stimulation were predominantly excitatory, grew in amplitude with increasing CV*, and consisted of fast and slow components that could be identified by differences in rise time and post-stimulus duration. Both efferent-mediated excitatory components were larger in irregular afferents with ipsilateral EVS stimulation. Our pharmacological data show, for the first time in mammals, that muscarinic AChR antagonists block efferent-mediated slow excitation whereas the nicotinic AChR antagonist DHβE selectively blocks efferent-mediated fast excitation, while leaving the efferent-mediated slow component intact. These data confirm that mammalian EVS actions are predominantly cholinergic." @default.
- W3120276766 created "2021-01-18" @default.
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- W3120276766 date "2021-01-13" @default.
- W3120276766 modified "2023-10-15" @default.
- W3120276766 title "The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents" @default.
- W3120276766 cites W1497815782 @default.
- W3120276766 cites W1863577573 @default.
- W3120276766 cites W1901070546 @default.
- W3120276766 cites W1929755832 @default.
- W3120276766 cites W1941006504 @default.
- W3120276766 cites W1964989012 @default.
- W3120276766 cites W1966518295 @default.
- W3120276766 cites W1979777579 @default.
- W3120276766 cites W1992562174 @default.
- W3120276766 cites W1993256970 @default.
- W3120276766 cites W1993683899 @default.
- W3120276766 cites W1996759313 @default.
- W3120276766 cites W2004216163 @default.
- W3120276766 cites W2005773226 @default.
- W3120276766 cites W2015539902 @default.
- W3120276766 cites W2018258068 @default.
- W3120276766 cites W2021693894 @default.
- W3120276766 cites W2022464801 @default.
- W3120276766 cites W2024369817 @default.
- W3120276766 cites W2029682530 @default.
- W3120276766 cites W2029712824 @default.
- W3120276766 cites W2032206244 @default.
- W3120276766 cites W2032656665 @default.
- W3120276766 cites W2036151072 @default.
- W3120276766 cites W2040231039 @default.
- W3120276766 cites W2042718175 @default.
- W3120276766 cites W2044500873 @default.
- W3120276766 cites W2046261125 @default.
- W3120276766 cites W2053438261 @default.
- W3120276766 cites W2056340622 @default.
- W3120276766 cites W2061569848 @default.
- W3120276766 cites W2061704188 @default.
- W3120276766 cites W2063223598 @default.
- W3120276766 cites W2067075667 @default.
- W3120276766 cites W2067420659 @default.
- W3120276766 cites W2069975465 @default.
- W3120276766 cites W2072250590 @default.
- W3120276766 cites W2076222045 @default.
- W3120276766 cites W2079428602 @default.
- W3120276766 cites W2082562281 @default.
- W3120276766 cites W2085091691 @default.
- W3120276766 cites W2087698910 @default.
- W3120276766 cites W2088354687 @default.
- W3120276766 cites W2090982164 @default.
- W3120276766 cites W2101328895 @default.
- W3120276766 cites W2104245476 @default.
- W3120276766 cites W2111683388 @default.
- W3120276766 cites W2128778628 @default.
- W3120276766 cites W2144281127 @default.
- W3120276766 cites W2146450044 @default.
- W3120276766 cites W2147285542 @default.
- W3120276766 cites W2159296820 @default.
- W3120276766 cites W2162829843 @default.
- W3120276766 cites W2166184000 @default.
- W3120276766 cites W2189162483 @default.
- W3120276766 cites W2207020406 @default.
- W3120276766 cites W2298212368 @default.
- W3120276766 cites W2301050636 @default.
- W3120276766 cites W2322557282 @default.
- W3120276766 cites W2339401365 @default.
- W3120276766 cites W2352055287 @default.
- W3120276766 cites W2413612697 @default.
- W3120276766 cites W2419644012 @default.
- W3120276766 cites W2528550547 @default.
- W3120276766 cites W2578039385 @default.
- W3120276766 cites W2578241464 @default.
- W3120276766 cites W2595705695 @default.
- W3120276766 cites W2750080190 @default.
- W3120276766 cites W2761443585 @default.
- W3120276766 cites W2773934686 @default.
- W3120276766 cites W2789474493 @default.
- W3120276766 cites W2888571898 @default.
- W3120276766 cites W2895999294 @default.
- W3120276766 cites W2905104301 @default.
- W3120276766 cites W2919471085 @default.
- W3120276766 cites W2956984253 @default.
- W3120276766 cites W2994232820 @default.
- W3120276766 cites W3039800818 @default.
- W3120276766 cites W3047589942 @default.
- W3120276766 cites W3080700106 @default.
- W3120276766 cites W3100707798 @default.
- W3120276766 cites W4327635065 @default.
- W3120276766 doi "https://doi.org/10.1038/s41598-020-80367-1" @default.
- W3120276766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7806594" @default.
- W3120276766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33441862" @default.
- W3120276766 hasPublicationYear "2021" @default.
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