FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120290489> ?p ?o ?g. }

• W3120290489 endingPage "108433" @default.
• W3120290489 startingPage "108433" @default.
• W3120290489 abstract "Although severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection have emerged globally, findings related to ocular involvement and reported cases are quite limited. Immune reactions against viral infections are closely related to viral and host proteins sequence similarity. Molecular Mimicry has been described for many different viruses; sequence similarities of viral and human tissue proteins may trigger autoimmune reactions after viral infections due to similarities between viral and human structures. With this study, we aimed to investigate the protein sequence similarity of SARS CoV-2 with retinal proteins and retinal pigment epithelium (RPE) surface proteins. Retinal proteins involved in autoimmune retinopathy and retinal pigment epithelium surface transport proteins were analyzed in order to infer their structural similarity to surface glycoprotein (S), nucleocapsid phosphoprotein (N), membrane glycoprotein (M), envelope protein (E), ORF1ab polyprotein (orf1ab) proteins of SARS CoV-2. Protein similarity comparisons, 3D protein structure prediction, T cell epitopes-MHC binding prediction, B cell epitopes-MHC binding prediction and the evaluation of the antigenicity of peptides assessments were performed. The protein sequence analysis was made using the Pairwise Sequence Alignment and the LALIGN program. 3D protein structure estimates were made using Swiss Model with default settings and analyzed with TM-align web server. T-cell epitope identification was performed using the Immune Epitope Database and Analysis (IEDB) resource Tepitool. B cell epitopes based on sequence characteristics of the antigen was performed using amino acid scales and HMMs with the BepiPred 2.0 web server. The predicted peptides/epitopes in terms of antigenicity were examined using the default settings with the VaxiJen v2.0 server. Analyses showed that, there is a meaningful similarities between 6 retinal pigment epithelium surface transport proteins (MRP-4, MRP-5, RFC1, SNAT7, TAUT and MATE) and the SARS CoV-2 E protein. Immunoreactive epitopic sites of these proteins which are similar to protein E epitope can create an immune stimulation on T cytotoxic and T helper cells and 6 of these 9 epitopic sites are also vaxiJen. These result imply that autoimmune cross-reaction is likely between the studied RPE proteins and SARS CoV-2 E protein. The structure of SARS CoV-2, its proteins and immunologic reactions against these proteins remain largely unknown. Understanding the structure of SARS CoV-2 proteins and demonstration of similarity with human proteins are crucial to predict an autoimmune response associated with immunity against host proteins and its clinical manifestations as well as possible adverse effects of vaccination." @default.
• W3120290489 created "2021-01-18" @default.
• W3120290489 creator A5001723125 @default.
• W3120290489 creator A5020042244 @default.
• W3120290489 creator A5039095878 @default.
• W3120290489 creator A5040890946 @default.
• W3120290489 creator A5047700570 @default.
• W3120290489 creator A5083834076 @default.
• W3120290489 date "2021-02-01" @default.
• W3120290489 modified "2023-10-18" @default.
• W3120290489 title "Using bioinformatic protein sequence similarity to investigate if SARS CoV-2 infection could cause an ocular autoimmune inflammatory reactions?" @default.
• W3120290489 cites W1585495565 @default.
• W3120290489 cites W19537414 @default.
• W3120290489 cites W1964298665 @default.
• W3120290489 cites W1964595004 @default.
• W3120290489 cites W1965167039 @default.
• W3120290489 cites W1968102802 @default.
• W3120290489 cites W1973307569 @default.
• W3120290489 cites W1973813421 @default.
• W3120290489 cites W1976293105 @default.
• W3120290489 cites W1983535430 @default.
• W3120290489 cites W1986094681 @default.
• W3120290489 cites W1998655756 @default.
• W3120290489 cites W2003499915 @default.
• W3120290489 cites W2005380527 @default.
• W3120290489 cites W2016333231 @default.
• W3120290489 cites W2017084881 @default.
• W3120290489 cites W2031265038 @default.
• W3120290489 cites W2051918598 @default.
• W3120290489 cites W2057825828 @default.
• W3120290489 cites W2059275162 @default.
• W3120290489 cites W2065050237 @default.
• W3120290489 cites W2073221620 @default.
• W3120290489 cites W2075138825 @default.
• W3120290489 cites W2075497661 @default.
• W3120290489 cites W2075878132 @default.
• W3120290489 cites W2076812487 @default.
• W3120290489 cites W2088779398 @default.
• W3120290489 cites W2090216336 @default.
• W3120290489 cites W2091821411 @default.
• W3120290489 cites W2100779666 @default.
• W3120290489 cites W2102245393 @default.
• W3120290489 cites W2102367710 @default.
• W3120290489 cites W2111953528 @default.
• W3120290489 cites W2125644345 @default.
• W3120290489 cites W2141116527 @default.
• W3120290489 cites W2142575954 @default.
• W3120290489 cites W2142739377 @default.
• W3120290489 cites W2156849432 @default.
• W3120290489 cites W2161406887 @default.
• W3120290489 cites W2162590249 @default.
• W3120290489 cites W2168688111 @default.
• W3120290489 cites W2170093149 @default.
• W3120290489 cites W2413811691 @default.
• W3120290489 cites W2559880627 @default.
• W3120290489 cites W2608011009 @default.
• W3120290489 cites W2611314002 @default.
• W3120290489 cites W2802987970 @default.
• W3120290489 cites W2928838901 @default.
• W3120290489 cites W2938574745 @default.
• W3120290489 cites W2955068995 @default.
• W3120290489 cites W2991313749 @default.
• W3120290489 cites W3001456238 @default.
• W3120290489 cites W3002528879 @default.
• W3120290489 cites W3013353381 @default.
• W3120290489 cites W3022285953 @default.
• W3120290489 cites W3025803855 @default.
• W3120290489 cites W3026051701 @default.
• W3120290489 cites W3030863679 @default.
• W3120290489 cites W3032902005 @default.
• W3120290489 cites W3035104625 @default.
• W3120290489 cites W3047718943 @default.
• W3120290489 cites W3048909141 @default.
• W3120290489 cites W3049455060 @default.
• W3120290489 cites W3090417570 @default.
• W3120290489 cites W3092870045 @default.
• W3120290489 cites W57517516 @default.
• W3120290489 doi "https://doi.org/10.1016/j.exer.2020.108433" @default.
• W3120290489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7831665" @default.
• W3120290489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33400927" @default.
• W3120290489 hasPublicationYear "2021" @default.
• W3120290489 type Work @default.
• W3120290489 sameAs 3120290489 @default.
• W3120290489 citedByCount "9" @default.
• W3120290489 countsByYear W31202904892021 @default.
• W3120290489 countsByYear W31202904892022 @default.
• W3120290489 countsByYear W31202904892023 @default.
• W3120290489 crossrefType "journal-article" @default.
• W3120290489 hasAuthorship W3120290489A5001723125 @default.
• W3120290489 hasAuthorship W3120290489A5020042244 @default.
• W3120290489 hasAuthorship W3120290489A5039095878 @default.
• W3120290489 hasAuthorship W3120290489A5040890946 @default.
• W3120290489 hasAuthorship W3120290489A5047700570 @default.
• W3120290489 hasAuthorship W3120290489A5083834076 @default.
• W3120290489 hasBestOaLocation W31202904891 @default.
• W3120290489 hasConcept C10010492 @default.
• W3120290489 hasConcept C104317684 @default.
• W3120290489 hasConcept C108625454 @default.

• next