FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120301274> ?p ?o ?g. }

• W3120301274 endingPage "3616" @default.
• W3120301274 startingPage "3596" @default.
• W3120301274 abstract "Homeorhetic mechanisms assist dairy cows in the transition from pregnancy to lactation. Less successful cows develop severe negative energy balance (NEB), placing them at risk of metabolic and infectious diseases and reduced fertility. We have previously placed multiparous Holstein Friesian cows from 4 herds into metabolic clusters, using as biomarkers measurements of plasma nonesterified fatty acids, β-hydroxybutyrate, glucose and IGF-1 collected at 14 and 35 d in milk (DIM). This study characterized the global transcriptomic profiles of liver and circulating leukocytes from the same animals to determine underlying mechanisms associated with their metabolic and immune function. Liver biopsy and whole-blood samples were collected around 14 DIM for RNA sequencing. All cows with available RNA sequencing data were placed into balanced (BAL, n = 44), intermediate (n = 44), or imbalanced (IMBAL, n = 19) metabolic cluster groups. Differential gene expression was compared between the 3 groups using ANOVA, but only the comparison between BAL and IMBAL cows is reported. Pathway analysis was undertaken using DAVID Bioinformatic Resources (https://david.ncifcrf.gov/). Milk yields did not differ between BAL and IMBAL cows but dry matter intake was less in IMBAL cows and they were in greater energy deficit at 14 DIM (−4.48 v −11.70 MJ/d for BAL and IMBAL cows). Significantly differentially expressed pathways in hepatic tissue included AMPK signaling, glucagon signaling, adipocytokine signaling, and insulin resistance. Genes involved in lipid metabolism and cholesterol transport were more highly expressed in IMBAL cows but IGF1 and IGFALS were downregulated. Leukocytes from BAL cows had greater expression of histones and genes involved in nucleosomes and cell division. Leukocyte expression of heat shock proteins increased in IMBAL cows, suggesting an unfolded protein response, and several key genes involved in immune responses to pathogens were upregulated (e.g., DEFB13, HP, OAS1Z, PTX3, and TLR4). Differentially expressed genes upregulated in IMBAL cows in both tissues included CD36, CPT1, KFL11, and PDK4, all central regulators of energy metabolism. The IMBAL cows therefore had greater difficulty maintaining glucose homeostasis and had dysregulated hepatic lipid metabolism. Their energy deficit was associated with a reduced capacity for cell division and greater evidence of stress responses in the leukocyte population, likely contributing to an increased risk of infectious disease." @default.
• W3120301274 created "2021-01-18" @default.
• W3120301274 creator A5003361227 @default.
• W3120301274 creator A5022219619 @default.
• W3120301274 creator A5039173692 @default.
• W3120301274 creator A5045137302 @default.
• W3120301274 creator A5052695473 @default.
• W3120301274 creator A5059060495 @default.
• W3120301274 creator A5065664811 @default.
• W3120301274 creator A5080270704 @default.
• W3120301274 creator A5082468343 @default.
• W3120301274 creator A5085725824 @default.
• W3120301274 creator A5089016003 @default.
• W3120301274 date "2021-03-01" @default.
• W3120301274 modified "2023-10-14" @default.
• W3120301274 title "Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation" @default.
• W3120301274 cites W1810681069 @default.
• W3120301274 cites W1820959305 @default.
• W3120301274 cites W1963729986 @default.
• W3120301274 cites W1964638367 @default.
• W3120301274 cites W1969788678 @default.
• W3120301274 cites W1970714799 @default.
• W3120301274 cites W1974065088 @default.
• W3120301274 cites W1981357380 @default.
• W3120301274 cites W2003792351 @default.
• W3120301274 cites W2003946092 @default.
• W3120301274 cites W2006652270 @default.
• W3120301274 cites W2008163846 @default.
• W3120301274 cites W2010029728 @default.
• W3120301274 cites W2013376826 @default.
• W3120301274 cites W2014418366 @default.
• W3120301274 cites W2017168436 @default.
• W3120301274 cites W2018204863 @default.
• W3120301274 cites W2025493596 @default.
• W3120301274 cites W2026816311 @default.
• W3120301274 cites W2027281436 @default.
• W3120301274 cites W2031913105 @default.
• W3120301274 cites W2035970054 @default.
• W3120301274 cites W2038026694 @default.
• W3120301274 cites W2039487747 @default.
• W3120301274 cites W2043701337 @default.
• W3120301274 cites W2046454491 @default.
• W3120301274 cites W2050325227 @default.
• W3120301274 cites W2053291546 @default.
• W3120301274 cites W2054289136 @default.
• W3120301274 cites W2057521072 @default.
• W3120301274 cites W2062536944 @default.
• W3120301274 cites W2065934375 @default.
• W3120301274 cites W2067654926 @default.
• W3120301274 cites W2069250488 @default.
• W3120301274 cites W2074448653 @default.
• W3120301274 cites W2077491140 @default.
• W3120301274 cites W2080869825 @default.
• W3120301274 cites W2083557677 @default.
• W3120301274 cites W2092225219 @default.
• W3120301274 cites W2098381128 @default.
• W3120301274 cites W2102224298 @default.
• W3120301274 cites W2102278945 @default.
• W3120301274 cites W2104005232 @default.
• W3120301274 cites W2105265356 @default.
• W3120301274 cites W2105319757 @default.
• W3120301274 cites W2108234281 @default.
• W3120301274 cites W2108542410 @default.
• W3120301274 cites W2108569942 @default.
• W3120301274 cites W2119714298 @default.
• W3120301274 cites W2121212588 @default.
• W3120301274 cites W2123402700 @default.
• W3120301274 cites W2124988143 @default.
• W3120301274 cites W2131271579 @default.
• W3120301274 cites W2133465414 @default.
• W3120301274 cites W2136268699 @default.
• W3120301274 cites W2141314779 @default.
• W3120301274 cites W2142995099 @default.
• W3120301274 cites W2149516406 @default.
• W3120301274 cites W2158217645 @default.
• W3120301274 cites W2158634391 @default.
• W3120301274 cites W2158945274 @default.
• W3120301274 cites W2163475317 @default.
• W3120301274 cites W2163477820 @default.
• W3120301274 cites W2164483717 @default.
• W3120301274 cites W2170654697 @default.
• W3120301274 cites W2171083495 @default.
• W3120301274 cites W2175559999 @default.
• W3120301274 cites W2188232396 @default.
• W3120301274 cites W2204433279 @default.
• W3120301274 cites W2344023359 @default.
• W3120301274 cites W2362101403 @default.
• W3120301274 cites W2505159449 @default.
• W3120301274 cites W2521925518 @default.
• W3120301274 cites W2566537266 @default.
• W3120301274 cites W2601836229 @default.
• W3120301274 cites W2603613888 @default.
• W3120301274 cites W2608757581 @default.
• W3120301274 cites W2747024293 @default.
• W3120301274 cites W2752186566 @default.
• W3120301274 cites W2761356900 @default.
• W3120301274 cites W2766951254 @default.
• W3120301274 cites W2767179042 @default.

• next