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- W3120331343 abstract "ncRNAs are crucial regulators of host biological processes varying from transcription to protein coding. Recent omics-based studies have revealed that ncRNAs, such as microRNAs and circular RNAs, modulate disease phenotypes in response to the gut microbiota/microbial metabolites during microbiome-linked pathologies such as cancers and obesity. Besides endogenous ncRNAs (expressed in host tissues or secreted into the blood and intestinal lumen), dietary exogenous ncRNAs can also modulate the intestinal microbiome and host. Application of knowledge generated through well controlled small-animal models needs to be validated through transdisciplinary approaches to develop regulatory ncRNAs into diagnostic tools and therapeutic agents to mitigate microbiome-linked pathologies in humans (and livestock). Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host–microbe interactions and they have been proposed as potential biomarkers of the host’s response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between microRNAs and circular RNAs, however, increase the complexity of the mechanisms that modulate host–microbe interactions. Current knowledge on these noncoding RNAs (ncRNAs) is mainly generated from well controlled germ-free or knockout (small) animal models. Application of such knowledge to effective modulation outcomes in humans (and livestock) is challenging due to the complex nature of microbiome-linked pathologies in larger outbred animals that constantly interact with the changing environment. This review critically discusses the findings of regulatory noncoding RNAs and their roles in microbiome-linked pathologies in small and large animals and provides insights on their roles as potential therapeutic agents to improve human (and livestock) health. Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host–microbe interactions and they have been proposed as potential biomarkers of the host’s response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between microRNAs and circular RNAs, however, increase the complexity of the mechanisms that modulate host–microbe interactions. Current knowledge on these noncoding RNAs (ncRNAs) is mainly generated from well controlled germ-free or knockout (small) animal models. Application of such knowledge to effective modulation outcomes in humans (and livestock) is challenging due to the complex nature of microbiome-linked pathologies in larger outbred animals that constantly interact with the changing environment. This review critically discusses the findings of regulatory noncoding RNAs and their roles in microbiome-linked pathologies in small and large animals and provides insights on their roles as potential therapeutic agents to improve human (and livestock) health." @default.
- W3120331343 created "2021-01-18" @default.
- W3120331343 creator A5052164943 @default.
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- W3120331343 date "2021-08-01" @default.
- W3120331343 modified "2023-10-17" @default.
- W3120331343 title "Noncoding RNAs: Regulatory Molecules of Host–Microbiome Crosstalk" @default.
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- W3120331343 doi "https://doi.org/10.1016/j.tim.2020.12.003" @default.
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