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- W3120354155 abstract "Bone remodeling is the continual process to renew the adult skeleton through the sequential action of osteoblasts and osteoclasts. Nuclear factor RANK, an osteoclast receptor, and its ligand RANKL, expressed on the surface of osteoblasts, result in coordinated control of bone remodeling. Inflammation, a feature of illness and injury, plays a distinct role in skewing this process toward resorption. It does so via the interaction of inflammatory mediators and their related peptides with osteoblasts and osteoclasts, as well as other immune cells, to alter the expression of RANK and RANKL. Such chemical mediators include TNFα, glucocorticoids, histamine, bradykinin, PGE2, systemic RANKL from immune cells, and interleukins 1 and 6. Conditions, such as periodontal disease and alveolar bone erosion, aseptic prosthetic loosening, rheumatoid arthritis, and some sports related injuries are characterized by the result of this process. A thorough understanding of bone response to injury and disease, and ability to detect such biomarkers, as well as imaging to identify early structural and mechanical property changes in bone architecture, is important in improving management and outcomes of bone related pathology. While gut health and vitamin and mineral availability appear vitally important, nutraceuticals also have an impact on bone health. To date most pharmaceutical intervention targets inflammatory cytokines, although strategies to favorably alter inflammation induced bone pathology are currently limited. Further research is required in this field to advance early detection and treatments." @default.
- W3120354155 created "2021-01-18" @default.
- W3120354155 creator A5005560434 @default.
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- W3120354155 date "2021-01-05" @default.
- W3120354155 modified "2023-10-10" @default.
- W3120354155 title "The Effect of Inflammation on Bone" @default.
- W3120354155 cites W1534343003 @default.
- W3120354155 cites W1547181907 @default.
- W3120354155 cites W1802397357 @default.
- W3120354155 cites W1803753513 @default.
- W3120354155 cites W1903727778 @default.
- W3120354155 cites W1953108821 @default.
- W3120354155 cites W1964188104 @default.
- W3120354155 cites W1965172675 @default.
- W3120354155 cites W1965696823 @default.
- W3120354155 cites W1966652024 @default.
- W3120354155 cites W1969323709 @default.
- W3120354155 cites W1972839818 @default.
- W3120354155 cites W1973652618 @default.
- W3120354155 cites W1975587041 @default.
- W3120354155 cites W1975953388 @default.
- W3120354155 cites W1977304732 @default.
- W3120354155 cites W1978107016 @default.
- W3120354155 cites W1983075114 @default.
- W3120354155 cites W1984721683 @default.
- W3120354155 cites W1985859336 @default.
- W3120354155 cites W1987479197 @default.
- W3120354155 cites W1991744930 @default.
- W3120354155 cites W1992916574 @default.
- W3120354155 cites W1994310131 @default.
- W3120354155 cites W2001069355 @default.
- W3120354155 cites W2001294282 @default.
- W3120354155 cites W2003733256 @default.
- W3120354155 cites W2011828467 @default.
- W3120354155 cites W2015527055 @default.
- W3120354155 cites W2017481744 @default.
- W3120354155 cites W2020238012 @default.
- W3120354155 cites W2021838232 @default.
- W3120354155 cites W2023910122 @default.
- W3120354155 cites W2024932182 @default.
- W3120354155 cites W2026086389 @default.
- W3120354155 cites W2027363930 @default.
- W3120354155 cites W2028077169 @default.
- W3120354155 cites W2033866180 @default.
- W3120354155 cites W2037297497 @default.
- W3120354155 cites W2038075677 @default.
- W3120354155 cites W2038354171 @default.
- W3120354155 cites W2041181827 @default.
- W3120354155 cites W2043503863 @default.
- W3120354155 cites W2044561904 @default.
- W3120354155 cites W2047159240 @default.
- W3120354155 cites W2049254268 @default.
- W3120354155 cites W2050940942 @default.
- W3120354155 cites W2053320649 @default.
- W3120354155 cites W2056910995 @default.
- W3120354155 cites W2061390212 @default.
- W3120354155 cites W2061958755 @default.
- W3120354155 cites W2062612633 @default.
- W3120354155 cites W2063048904 @default.
- W3120354155 cites W2063148382 @default.
- W3120354155 cites W2063216829 @default.
- W3120354155 cites W2063528254 @default.
- W3120354155 cites W2074906434 @default.
- W3120354155 cites W2076709268 @default.
- W3120354155 cites W2082047692 @default.
- W3120354155 cites W2083910191 @default.
- W3120354155 cites W2085016903 @default.
- W3120354155 cites W2086200310 @default.
- W3120354155 cites W2088297260 @default.
- W3120354155 cites W2088595669 @default.
- W3120354155 cites W2091419870 @default.
- W3120354155 cites W2093120748 @default.
- W3120354155 cites W2093252878 @default.
- W3120354155 cites W2093445814 @default.
- W3120354155 cites W2093847268 @default.
- W3120354155 cites W2094354621 @default.
- W3120354155 cites W2095139297 @default.
- W3120354155 cites W2097322302 @default.
- W3120354155 cites W2103775523 @default.
- W3120354155 cites W2106850940 @default.
- W3120354155 cites W2111913226 @default.
- W3120354155 cites W2114589447 @default.
- W3120354155 cites W2114738387 @default.
- W3120354155 cites W2118994799 @default.
- W3120354155 cites W2121867073 @default.
- W3120354155 cites W2125243655 @default.
- W3120354155 cites W2128816394 @default.
- W3120354155 cites W2132408993 @default.
- W3120354155 cites W2132933661 @default.
- W3120354155 cites W2133736237 @default.
- W3120354155 cites W2135166538 @default.
- W3120354155 cites W2136157472 @default.
- W3120354155 cites W2137717947 @default.
- W3120354155 cites W2138754612 @default.
- W3120354155 cites W2144206769 @default.