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• W3120367675 abstract "The nocturnal secretion of melatonin by the pineal gland drives photoperiodic seasonal rhythms in mammals. In turn, the pineal is controlled by daily cues generated intrinsically by the circadian (circa- approximately, −diem a day) clock of the hypothalamic suprachiasmatic nucleus (SCN). Photic cues from the retina both synchronize the SCN and also acutely suppress melatonin synthesis. As a result, the duration of the nocturnal secretion of melatonin encodes the length of the night and hence season. This chapter will consider recent developments in understanding how the SCN generates an internal representation of solar time and thereby functions as a clock and calendar. The first level of timekeeping pivots around intracellular transcriptional and translational feedback loops (TTFLs) that constitute cell-autonomous circadian timers. These mechanisms are common to many, if not all, mammalian tissues, but three properties beyond its TTFLs make the SCN the principal pacemaker. First, it is the sole component of the mammalian circadian system to receive retinal input and is therefore directly entrained to the cycle of day and night. The TTFLs of SCN cells are therefore a high-fidelity, internal proxy of solar time. Second, its neural connections to the hypothalamus and beyond enable the SCN to direct rhythmic endocrine (including melatonin) and autonomic and behavioral rhythms that in turn coordinate the innumerable cellular and tissue-based clocks distributed across the body. Third, the timekeeping power that enables the SCN to sustain this internal coordination is derived from the circuit-level integration of the ~20,000 neurons into a robust and resilient circuit-level pacemaker. Activity across the cellular TTFLs is tightly synchronized but not simultaneous, as cells peak in activity in different phases. Importantly, this network-level pattern of activity is plastic, the long days of summer increasing the phase dispersal between cells. This response of the SCN to daylength causes a reciprocal widening or narrowing of the dependent melatonin profile. The daily clock thereby generates an internal representation of season. The intercellular mechanisms that underpin network integration are twofold. First, neuropeptidergic cues released from various populations of SCN neurons act in a slow paracrine manner, over circadian time and SCN circuit space, to synchronize and amplify the individual intracellular TTFLs. Second, it has recently become clear that astrocytes play an important role in network function, as they are able to initiate SCN neuronal oscillations and behavioral circadian rhythms and impose their own cell-autonomous period. Analysis of the network-level interactions between neurons and astrocytes will therefore advance understanding of how both circadian and seasonal information is encoded and distributed by the SCN." @default.
• W3120367675 created "2021-01-18" @default.
• W3120367675 creator A5014997137 @default.
• W3120367675 creator A5048437113 @default.
• W3120367675 date "2020-01-01" @default.
• W3120367675 modified "2023-09-23" @default.
• W3120367675 title "Circadian Timekeeping in the Suprachiasmatic Nucleus: Genes, Neurotransmitters, Neurons, and Astrocytes" @default.
• W3120367675 cites W1504276952 @default.
• W3120367675 cites W1544822821 @default.
• W3120367675 cites W1564855882 @default.
• W3120367675 cites W1964949721 @default.
• W3120367675 cites W1967984848 @default.
• W3120367675 cites W1973369235 @default.
• W3120367675 cites W1975191711 @default.
• W3120367675 cites W1975631797 @default.
• W3120367675 cites W1976521197 @default.
• W3120367675 cites W1978813149 @default.
• W3120367675 cites W1979032340 @default.
• W3120367675 cites W1979662292 @default.
• W3120367675 cites W1981589604 @default.
• W3120367675 cites W1981821197 @default.
• W3120367675 cites W1983875092 @default.
• W3120367675 cites W1992182952 @default.
• W3120367675 cites W1994922657 @default.
• W3120367675 cites W2003302378 @default.
• W3120367675 cites W2005610541 @default.
• W3120367675 cites W2006612479 @default.
• W3120367675 cites W2009077913 @default.
• W3120367675 cites W2011072921 @default.
• W3120367675 cites W2014028088 @default.
• W3120367675 cites W2014313900 @default.
• W3120367675 cites W2020244230 @default.
• W3120367675 cites W2021607553 @default.
• W3120367675 cites W2022197238 @default.
• W3120367675 cites W2024614792 @default.
• W3120367675 cites W2027704011 @default.
• W3120367675 cites W2030366252 @default.
• W3120367675 cites W2032793852 @default.
• W3120367675 cites W2034348289 @default.
• W3120367675 cites W2035853180 @default.
• W3120367675 cites W2044934033 @default.
• W3120367675 cites W2049285778 @default.
• W3120367675 cites W2050198408 @default.
• W3120367675 cites W2053210485 @default.
• W3120367675 cites W2057522076 @default.
• W3120367675 cites W2066445429 @default.
• W3120367675 cites W2082433800 @default.
• W3120367675 cites W2095326601 @default.
• W3120367675 cites W2096683871 @default.
• W3120367675 cites W2096819583 @default.
• W3120367675 cites W2096882849 @default.
• W3120367675 cites W2104290916 @default.
• W3120367675 cites W2105050095 @default.
• W3120367675 cites W2111374626 @default.
• W3120367675 cites W2111700367 @default.
• W3120367675 cites W2112816452 @default.
• W3120367675 cites W2113671711 @default.
• W3120367675 cites W2125174187 @default.
• W3120367675 cites W2126435291 @default.
• W3120367675 cites W2130888975 @default.
• W3120367675 cites W2134377844 @default.
• W3120367675 cites W2137304828 @default.
• W3120367675 cites W2143506081 @default.
• W3120367675 cites W2151131721 @default.
• W3120367675 cites W2153042537 @default.
• W3120367675 cites W2159545621 @default.
• W3120367675 cites W2164166968 @default.
• W3120367675 cites W2167819427 @default.
• W3120367675 cites W2170167067 @default.
• W3120367675 cites W2170538407 @default.
• W3120367675 cites W2285029219 @default.
• W3120367675 cites W2289666789 @default.
• W3120367675 cites W2294512259 @default.
• W3120367675 cites W2313752937 @default.
• W3120367675 cites W2335980268 @default.
• W3120367675 cites W2389771398 @default.
• W3120367675 cites W2406604088 @default.
• W3120367675 cites W2493982139 @default.
• W3120367675 cites W2509607702 @default.
• W3120367675 cites W2511951709 @default.
• W3120367675 cites W2512944917 @default.
• W3120367675 cites W2513960057 @default.
• W3120367675 cites W2536387389 @default.
• W3120367675 cites W2560772587 @default.
• W3120367675 cites W2560908995 @default.
• W3120367675 cites W2603862537 @default.
• W3120367675 cites W2742404169 @default.
• W3120367675 cites W2743573251 @default.
• W3120367675 cites W2763278454 @default.
• W3120367675 cites W2777700910 @default.
• W3120367675 cites W2781911216 @default.
• W3120367675 cites W2803722031 @default.
• W3120367675 cites W2803783038 @default.
• W3120367675 cites W2808964483 @default.
• W3120367675 cites W2885780308 @default.
• W3120367675 cites W2901993517 @default.
• W3120367675 cites W2910780660 @default.
• W3120367675 cites W2913418165 @default.

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