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- W3120369425 abstract "A new homoisoflavan, identified as (3 R)-7-hydroxy-3',4'-methylenedioxyhomoisoflavan, was isolated from Dracaena cinnabari Balf. f. resin. The structure was elucidated by one- and two-dimensional NMR spectroscopy as well as high resolution mass spectrometry. In addition, a diverse group of flavonoids were isolated, representing homoisoflavans, flavans, flavanones, chalcones and dihydrochalcones. The compounds were evaluated for their α-glucosidase and COX-II inhibition activity. The obtained IC50 values of the tested flavonoids gave an insight about some key structural features to their α-glucosidase and COX-II inhibitory activity. For α-glucosidase inhibitory activity, a flavanone skeleton was favorable over a flavan. For COX-II inhibition, the introduction of a fused heterocyclic ring at the homoisoflavan skeleton enhanced the activity." @default.
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- W3120369425 date "2021-01-11" @default.
- W3120369425 modified "2023-09-27" @default.
- W3120369425 title "A new homoisoflavan from <i>Dracaena cinnabari</i> Balf. f. resin: α-glucosidase and COX-II inhibitory activity" @default.
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- W3120369425 doi "https://doi.org/10.1080/14786419.2020.1869229" @default.
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