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- W3120403812 endingPage "196" @default.
- W3120403812 startingPage "196" @default.
- W3120403812 abstract "The relatively rapid shift from consuming preagricultural wild foods for thousands of years, to consuming postindustrial semi-processed and ultra-processed foods endemic of the Western world less than 200 years ago did not allow for evolutionary adaptation of the commensal microbial species that inhabit the human gastrointestinal (GI) tract, and this has significantly impacted gut health. The human gut microbiota, the diverse and dynamic population of microbes, has been demonstrated to have extensive and important interactions with the digestive, immune, and nervous systems. Western diet-induced dysbiosis of the gut microbiota has been shown to negatively impact human digestive physiology, to have pathogenic effects on the immune system, and, in turn, cause exaggerated neuroinflammation. Given the tremendous amount of evidence linking neuroinflammation with neural dysfunction, it is no surprise that the Western diet has been implicated in the development of many diseases and disorders of the brain, including memory impairments, neurodegenerative disorders, and depression. In this review, we discuss each of these concepts to understand how what we eat can lead to cognitive and psychiatric diseases." @default.
- W3120403812 created "2021-01-18" @default.
- W3120403812 creator A5003105066 @default.
- W3120403812 creator A5006794710 @default.
- W3120403812 creator A5041777589 @default.
- W3120403812 date "2021-01-10" @default.
- W3120403812 modified "2023-10-09" @default.
- W3120403812 title "Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health" @default.
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